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R(+)-BAY K 8644

R(+)-BAY K 8644 Structure
R(+)-BAY K 8644 structure
CAS No.
98791-67-4
Chemical Name:
R(+)-BAY K 8644
Synonyms
R-4407;NI 105;BAY-r-4407;BAY-k 4407;(+)-BAY-K-8644;R(+)-BAY K 8644;Bay-K-8644 ((R)-(+)-);R(+)-BAY K 8644 98% 0 C;(+/-)-BAY K 8644, 0 TO 5 °C;(R)(+)BayK8644,(R) (+) Bay K 8644
CBNumber:
CB9218808
Molecular Formula:
C16H15F3N2O4
Molecular Weight:
356.3
MDL Number:
MFCD00153768
MOL File:
98791-67-4.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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R(+)-BAY K 8644 Properties

storage temp. 2-8°C
solubility H2O: slightly soluble
form solid
color yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

R(+)-BAY K 8644 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15263 (+)-BAY-K-8644 ≥98% 98791-67-4 1mg $110 2024-03-01 Buy
Cayman Chemical 15263 (+)-BAY-K-8644 ≥98% 98791-67-4 5mg $218 2024-03-01 Buy
Cayman Chemical 15263 (+)-BAY-K-8644 ≥98% 98791-67-4 10mg $273 2024-03-01 Buy
Tocris 1545 (R)-(+)-BayK8644 ≥97%(HPLC) 98791-67-4 50 $1184 2021-12-16 Buy
TRC B119010 (R)-(+)-BayK8644 98791-67-4 2.5mg $225 2021-12-16 Buy
Product number Packaging Price Buy
15263 1mg $110 Buy
15263 5mg $218 Buy
15263 10mg $273 Buy
1545 50 $1184 Buy
B119010 2.5mg $225 Buy

R(+)-BAY K 8644 Chemical Properties,Uses,Production

Description

BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(−)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.

Uses

(R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Definition

ChEBI: (R)-Bay-K-8644 is a methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate in which the 4-position has (R)-configuration. It is an enantiomer of a (S)-Bay-K-8644.

Biological Activity

L-type Ca 2+ -channel blocker with negative inotropic and vasodilatatory effects in vivo . Enantiomer showing opposite effects to the racemate (1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester ) and (S)-(-)- enantiomer ((4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester ). In combination with BIX-01294, helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs).

storage

Store at +4°C

R(+)-BAY K 8644 Preparation Products And Raw materials

Raw materials

Preparation Products

R(+)-BAY K 8644 Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189 mychess007@163.com China 1994 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8449 60
Supplier Advantage
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
InvivoChem 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
ShangHai KenEn Chemical Technology Co., Ltd. 55
EMMX Biotechnology LLC 60

98791-67-4(R(+)-BAY K 8644)Related Search:

2-methyl-1-nitropropane 3-[o-(alpha,alpha,alpha-trifluorotolyl)]propionic acid Phenibut 4-AMINO-3-PHENYL-1-BUTANOL 3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONALDEHYDE
METHYL 4-NITROBUTYRATE o-(trifluoromethyl)phenethylamine BETA-(NITROMETHYL)-BENZENEPROPANOIC ACID 1-NITRO-2-METHYL-BUTANE R(+)-BAY K 8644
3-(2-TRIFLUOROMETHYL-PHENYL)-PROPAN-1-OL (+/-)-BAY K8644 CALCIUM SLOW CHANNEL,(RS)-BAY K 8644,BAY K-8644 (+/-),(+/-)-BAY K 8644 3-[(2-TRIFLUOROMETHYL)PHENYL]-1-PROPENE BAY K-8644 (+/-),(+/-)-BAY K 8644 S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO,S(-)-BAY K 8644
R(+)-BAY K 8644 CALCIUM CHANNEL (+-)-CAGED BAY K 8644 3-METHYL-4-NITRO-BUTYRALDEHYDE

1of4

(4R)-1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-[(2-TRIFLUOROMETHYL)PHENYL]-3-PYRIDINECARBOXYLIC ACID METHYL ESTER R-(+)-1,4-DIHYDRO-2,6-DIMETHY-5-NITRO-(2-[TRIFLUOROMETHYL]-PHENYL)-3-PYRIDINE CARBOXYLIC ACID METHYL ESTER R(+)-BAY K 8644 R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE (+/-)-BAY K 8644, 0 TO 5 °C R(+)-BAY K 8644 98% 0 C (4R)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethyl)phenyl)-3-pyridinecarboxylicacidmethylester r-(+)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester [4R,(+)]-1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl)pyridine-3-carboxylic acid methyl ester BAY-r-4407 R-4407 BAY-k 4407 NI 105 Bay-K-8644 ((R)-(+)-) BAY-K-8644 ((R)-(+)-);R-4407;NI-105;(+)-BAY-K-8644 (+)-methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoromethylphenyl)pyridine-5-carboxylate 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-, methyl ester, (4R)- (+)-BAY-K-8644 (R)(+)BayK8644,(R) (+) Bay K 8644 98791-67-4 Calcium channel