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Methimazole

description Chemical properties Uses Production methods
Methimazole
Methimazole structure
CAS No.
60-56-0
Chemical Name:
Methimazole
Synonyms
Basolan;Metizol;Favistan;Metazolo;Tapuzole;METAZOLE;TAPAZOLE;Frentirox;Mercazole;Merkastan
CBNumber:
CB9220870
Molecular Formula:
C4H6N2S
Formula Weight:
114.17
MOL File:
60-56-0.mol

Methimazole Properties

Melting point:
144-147 °C(lit.)
Boiling point:
280 °C
Density 
1.176 (estimate)
refractive index 
1.5000 (estimate)
Flash point:
280°C
storage temp. 
Refrigerator
solubility 
200g/l
pka
12.37±0.50(Predicted)
form 
Crystalline Powder
color 
White to slightly cream or pale buff
Water Solubility 
soluble
Merck 
14,5971
BRN 
108646
CAS DataBase Reference
60-56-0(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
554Z48XN5E
NIST Chemistry Reference
Methimazole(60-56-0)
IARC
3 (Vol. 79) 2001
Proposition 65 List
Methimazole
EPA Substance Registry System
Methimazole (60-56-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS08
Signal word  Warning
Hazard statements  H317-H361-H303
Precautionary statements  P201-P261-P308+P313-P405-P501a-P280
Hazard Codes  Xn
Risk Statements  43-62-63-22
Safety Statements  26-27-36-45-36/37
WGK Germany  3
RTECS  NI8615000
TSCA  Yes
HS Code  29332990
NFPA 704
1
1 0

Methimazole price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 301507 2-Mercapto-1-methylimidazole ≥99% 60-56-0 5g $59 2020-08-18 Buy
Sigma-Aldrich 1411005 Methimazole United States Pharmacopeia (USP) Reference Standard 60-56-0 200mg $366 2020-08-18 Buy
TCI Chemical M0868 2-Mercapto-1-methylimidazole >98.0%(HPLC)(T) 60-56-0 25g $95 2020-06-24 Buy
Alfa Aesar A13094 2-Mercapto-1-methylimidazole, 98% 60-56-0 25g $44.3 2020-06-24 Buy
Alfa Aesar A13094 2-Mercapto-1-methylimidazole, 98% 60-56-0 100g $164 2020-06-24 Buy

Methimazole Chemical Properties,Uses,Production

description

Methimazole is an antithyroid medication used in the therapy of hyperthyroidism and Graves disease. It works by making it harder for the body to make thyroid hormone.
It is also known as thiamazole, is a thioamide and a thyroid hormone antagonist which acts by inhibiting the incorporation of iodine into tyrosyl residues of thyroglobulin and, thus, lowering thyroid hormone levels.
It resembles propylthiouracil both in chemical structure and activity.
Methimazole is primarily used for the treatment of hyperthyroidism, by inhibiting the peroxidase system, hindering thyroxine (T4) and tri-triiodothyronine (T3) synthesis, animal experiments show that it can inhibit B lymphocytes synthesizing antibodies, and reduce levels of thyroid stimulating antibodies in blood circulating it can make suppressing T cell function return to normal, it is applicable to hyperthyroidism caused by a variety of factors . Like other various drugs (propylthiouracil), it also has some adverse reactions while it is taken, Including hematologic adverse reactions, primarily neutropenia, hematopoietic dysfunction or disorder, thrombocytopenia, reduction of prothrombin or factor VII ; long-term medication can also cause liver damage,such as cholestatic jaundice and toxic hepatitis ; other skin reactions such as hair loss, itching, rash, dermatitis, lupus erythematosus, as well as some other rare adverse reactions. Also methimazole allows prothrombin time to prolong , and increases serum alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT)and causes blood bilirubin and blood lactate dehydrogenase increasing. Therefore, patients in the medication should regularly take blood tests, liver function tests and peripheral blood leukocytes.
The above information is edited by the Chemicalbook of Tian Ye.

Chemical properties

leaf-shaped crystalline (ethanol), melting point 146-148 ℃, boiling point 280 ℃ (decomposition), soluble in water, soluble in alcohol, chloroform, slightly soluble in ether, benzene.

Uses

Carbimazole intermediates.
anti-thyroid drugs.

Production methods

React amino acetal with methyl isothiocyanate to genarate this product. The product can also be produced from thiocyanate and N-substituted amino acetal.

Chemical Properties

White Solid

Originator

Favistan ,Asta

Uses

Methimazole is a thiourea antithyroid agent that prevents iodine organification, thus inhibiting the synthesis of thyroxine. Antihyperthyroid

Manufacturing Process

2 Methods of preparation of thiamazole:
1. To 2,2-diethoxyethylamine methylisothiocyanate was added and mixed after then 1-(2,2-diethoxy-ethyl)-3-methylthiourea was obtained.
The reaction of the 1-(2,2-diethoxyethyl)-3-methylthiourea with sulfuric acid yield thiamazole.
2. 1,1-Diethoxyethane was treated by bromine in the presence CaCO3 and 2- bromo-1,1-diethoxyethane was obtained.
Then to the 2-bromo-1,1-diethoxyethane methylamine was added, mixed and reaction mixture was heated to 120°-130°C in autoclave. As the result (2,2- diethoxyethyl)methylamine was obtained.
(2,2-Diethoxyethyl)methylamine reacted with potassium thiocyanate in the presence of hydrochloric acid and give the thiamazole, yellow crystallic precipitate, melting point 144°-147°C.

brand name

Tapazole (Jones); Tapazole (King) .

Therapeutic Function

Thyroid inhibitor

General Description

Methimazole, 1-methylimidazole-2-thiol (Tapazole), occurs as a white to off-white, crystallinepowder with a characteristic odor and is freely soluble inwater. A 2% aqueous solution has a pH of 6.7 to 6.9. It shouldbe packaged in well-closed, light-resistant containers.

Clinical Use

Methimazole is indicated in the treatment of hyperthyroidism.It is more potent than propylthiouracil. The side effectsare similar to those of propylthiouracil. As with otherantithyroid drugs, patients using this drug should be undermedical supervision. Also, like the other antithyroid drugs,methimazole is most effective if the total daily dose is subdividedand given at 8-hour intervals.

Safety Profile

Poison by subcutaneous route. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects. An experimental teratogen. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Human mutation data reported. An antithyroid drug. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also MERCAPTANS.

Veterinary Drugs and Treatments

Methimazole is considered by most clinicians to be the agent of choice when using drugs to treat feline hyperthyroidism. Propylthiouracil has significantly higher incidences of adverse reactions when compared to methimazole and is rarely used today. Transdermal methimazole (in PLO gel; 2.5 mg twice daily) has been used with some therapeutic success in cats that do not tolerate oral dosing. Efficacy may require four or more weeks to detect. Studies are ongoing.
Methimazole appears to be useful for the prophylactic prevention of cisplatin induced nephrotoxicity in dogs.

Purification Methods

Crystallise it from EtOH. UV: at 251nm (H2O), 260nm (EtOH) and 267nm (CHCl3). [Lawson max & Morley J Chem Soc 1103 1956, Beilstein 24 H 17, 24 III/IV 61.]

Methimazole Preparation Products And Raw materials

Raw materials

Preparation Products


Methimazole Suppliers

Global( 284)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21842 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24886 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Shanghai Arbor Chemical Co., Ltd.
021-60451682
021-60451683 act@arborchemical.com CHINA 906 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58

View Lastest Price from Methimazole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-17 MethiaMazole
60-56-0
US $980.00 / KG 1KG 98.0% 1T Shaanxi Dideu Medichem Co. Ltd
2018-08-20 Methimazole
60-56-0
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-08-09 Methimazole
60-56-0
US $1.00 / KG 1KG 98% 100KG career henan chemical co

Methimazole Spectrum


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