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DMT-dC(bz) Phosphoramidite

DMT-dC(bz) Phosphoramidite structure

CAS No.: 102212-98-6

Chemical Name:: DMT-dC(bz) Phosphoramidite

Synonyms: DMT-dC(Bz)-CE;DMT-dC(bz) amidite;DNAC-PHOSPHORAMIDITE;Bz-dC Phosphoramidite;DMT-dC(Bz)-CE Amidites;DMT-dC-CEPhosphoramidite;dC(Bz) CE Phosphoramidite;DMT-dC(bz) Phosphoramidite;dC (N-Bz) Phosphoramidite;deoxy N-Bz Cytidine Amidite

CBNumber:: CB9226852

Molecular Formula:: C46H52N5O8P

Molecular Weight:: 833.91

MDL Number:: MFCD00036315

MOL File:: 102212-98-6.mol

Last updated:2023-12-15 10:41:05

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DMT-dC(bz) Phosphoramidite Properties

Melting point	>84°C (dec.)
Density	1.23 at 20℃
vapor pressure	0-0Pa at 20-50℃
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform, DMSO, Methanol (Slightly)
form	powder or granules
pka	8.65±0.20(Predicted)
color	white to off-white
InChIKey	PGTNFMKLGRFZDX-SALLYJDFSA-N
SMILES	O(C(C1=CC=C(OC)C=C1)(C1=CC=C(OC)C=C1)C1=CC=CC=C1)C[C@H]1O[C@@H](N2C=CC(NC(=O)C3=CC=CC=C3)=NC2=O)C[C@@H]1OP(N(C(C)C)C(C)C)OCCC#N \|&1:25,27,45,r\|
LogP	6.5 at 20℃

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Safety Statements	24/25
WGK Germany	3
HS Code	29349990

DMT-dC(bz) Phosphoramidite price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C111040	DMT-dC(bz) Phosphoramidite configured for MerMade	102212-98-6	6x5g	$737	2024-03-01	Buy
Sigma-Aldrich	C111040	DMT-dC(bz) Phosphoramidite configured for MerMade	102212-98-6	6x10g	$982	2024-03-01	Buy
Sigma-Aldrich	C111000	DMT-dC(bz) Phosphoramidite ≥99% (31P-NMR)	102212-98-6	6x10g	$982	2024-03-01	Buy
Sigma-Aldrich	C111000	DMT-dC(bz) Phosphoramidite	102212-98-6	208.6g	$3430	2024-03-01	Buy
Sigma-Aldrich	C111000	DMT-dC(bz) Phosphoramidite ≥99% (31P-NMR)	102212-98-6	1kg	$13480	2024-03-01	Buy

Product number	Packaging	Price	Buy
C111040	6x5g	$737	Buy
C111040	6x10g	$982	Buy
C111000	6x10g	$982	Buy
C111000	208.6g	$3430	Buy
C111000	1kg	$13480	Buy

DMT-dC(bz) Phosphoramidite Chemical Properties,Uses,Production

Chemical Properties

DMT-dC(bz) Phosphoramidite, also known as 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite or (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (IUPAC Name), is a novel nucleoside amidite analog, which can be subjected in the synthesis of DNA.
DMT-dC(bz) Phosphoramidite belongs to the group of DNA Phosphoramidites.Its key features include:
Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides.

Uses

5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Synthesis

Synthesis_102212-98-6
These Examples illustrate the phosphitylation of several protected nucleoside reagents with 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite in the presence of several activators according to the present invention. Eleven phosphitylation reactions (1-11) comprising reacting a protected nucleoside reagent with 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite in the presence of an acid-base activator according to the present invention were conducted, and the product yields of each calculated, as described in the General Procedure, below. The various combinations of protected nucleoside, activator base, activator acid, solvent, and yield for each of the 11 reactions are listed in Table 1. General Procedure: The activator base (1.1 to 1.2 equivalents) is added to the solvent and 0.95 to 1.1 equivalents of activator acid is subsequently added thereto at ambient temperature to form the activator solution. About 1 equivalent of the protected nucleoside is dissolved in about 10 equivalents of the solvent in a separate vessel and about 3 equivalents of the solvent is then distilled off under reduced pressure. About 1 to 1.2 equivalents of 2-Cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite is added to the nucleoside mixture at ambient temperature, and the activator solution prepared previously is then added to the nucleoside mixture at ambient temperature with vigorous stirring. After 12 hours, the reaction mixture is diluted with toluene and washed with water. The organic layer is separated, dried over sodium sulfate if necessary, and concentrated under reduced pressure. The yield of the desired amidite is then calculated using HPLC techniques, that is, the resulting product mixture is run through an HPLC column using an appropriate eluent, and the area under the HPLC peaks used to determine the %yield of product in the mixture.

DMT-dC(bz) Phosphoramidite Preparation Products And Raw materials

Raw materials

Preparation Products

DMT-dC(bz) Phosphoramidite Suppliers

Global( 175)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhejiang Hengkang Pharmaceutical Co., Ltd.	+86-576-83372028 +86-18868723926	bd1@hengkangpharm.cn	China	119	58
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1472	58
Hefei Huana Biomedical Technology Co.,Ltd.	+86-15900695956	shiqin.he@huanaok.com.cn	China	96	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Nanjing Baifuli Technology Co., Ltd.	+86-15335185688	sales@unisyn.cn	CHINA	332	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58

Supplier	Advantage
Zhejiang Hengkang Pharmaceutical Co., Ltd.	58
Chemtour Biotech Co., Ltd	58
Hefei Huana Biomedical Technology Co.,Ltd.	58
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Yunbio Tech Co.,Ltd.	58
Nanjing Baifuli Technology Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58

View Lastest Price from DMT-dC(bz) Phosphoramidite manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-04-04	DMT-dC(Bz) Phosphoramidite 102212-98-6	US $0.00-0.00 / kg	1kg	98%	500kg per month	Zhejiang Hengkang Pharmaceutical Co., Ltd.
2023-03-22	dC(Bz) CE Phosphoramidite 102212-98-6	US $100.00 / kg	0.009999999776482582kg	99%	5tons	SHANGHAI NOVRIBO BIOTECH
2023-03-14	DMT-dC(Bz)-CE 102212-98-6	US $0.00 / mg	100mg	≥99%	20tons	Hefei Huana Biomedical Technology Co.,Ltd.

DMT-dC(Bz) Phosphoramidite
102212-98-6
US $0.00-0.00 / kg
98%
Zhejiang Hengkang Pharmaceutical Co., Ltd.

dC(Bz) CE Phosphoramidite
102212-98-6
US $100.00 / kg
99%
SHANGHAI NOVRIBO BIOTECH

DMT-dC(Bz)-CE
102212-98-6
US $0.00 / mg
≥99%
Hefei Huana Biomedical Technology Co.,Ltd.

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REF DUPL: DMT-dC(bz) Phosphoramidite Bz-dC Phosphoramidite N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite ,98% N4-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite 2'-DEOXYCYTIDINE PHOSPHORAMIDITE DNAC-PHOSPHORAMIDITE dC (N-Bz) Phosphoramidite N-blocked-5'-O-DMT 3'-CED deoxycytidine phosphoramidite (2R,3S,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl 2-cyanoethyl diisopropylphosphoramidite DMT-dC(bz) Phosphoramidite DMT-DC(BZ) AMIDITE 2G AB 12 PACK 3'-O-P-5'-O-DMT-N-BZ-2'-DEOXY-CYTIDINE [DC(BZ) PHOSPHORAMIDITE] 5'-Dimethoxytrityl-N-benzoyl-3'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite DMT-dC-CEPhosphoramidite N⁴-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoraMidite DMT-dC(bz) Amidite 1g, 89, 12 Pack DMT-dC(bz) Amidite 20g, 6 Pack DMT-DC(BZ) AMIDITE 5G 6 PACK DMT-dC(bz) Amidite 4g, 60ml vial, 12 Pac DMT-dC(bz) Amidite 2g, 60ml vial, 12 Pac DMT-DC(BZ) AMIDITE 10G 6 PACK DMT-DC(BZ) AMIDITE 10G SINGLE DMT-DC(BZ) AMIDITE 1G AB 12 PACK DMT-dC(bz) Amidite 1g, 60ml vial, 12 Pac DMT-dC(bz) Amidite 7.65g, 6 Pack DMT-DC(BZ) AMIDITE 5G SINGLE DMT-DC(BZ) AMIDITE 2G 89 12 PACK N4-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxycytidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite] N6-Benzoyl-5'-O-DMT-2'-deoxycytidine-3'-CE Phosphoramidite DMT-dC(Bz)-CE Phosphoramidite N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl Phosphoramidite DMT-dC(bz) amidite n-benzoyl-5'-o-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-cytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] N4-BENZOYL-5'-O-(DIMETHOXYTRITYL)-2'-DEOXYCYTIDINE-3'-N,N-DIISOPROPYL (CYANOETHYL) PHOSPHORAMIDITE 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-2'-DEOXYCYTIDINE-3'-(2-CYANOETHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE 5'-O-DMT-N4-Benzoyl-2'-deoxycytidine 3'-CE phosphoramidite N⁴-Benzoyl-2'-deoxy-5'-O-DMT-cytidine 3'-CE phosphoramidite, 99%, R and S mixture dC(bz) β-Cyanoethylphosphoramidite (mixture of isomers)isomers) Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] N4-Benzoyl-5'-O-DMT-2'-deoxycytidine 3'-CE phosphoramidite DMT-dC(bz) Phosphoramidite USP/EP/BP 5'-DMT-Bz-dC phosphoramidite 5'-Dimethoxytrityl-N-benzoyl-2'-deoxyCytidine,3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite N4-Benzoyl-5'-O-(4,4'-DMT)-2’-dC-3'-CE Phosphoramidite 5-O-(4,4-Dimethoxytrityl)-N4-benzoyl-2-deoxycytidine-3-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite 5'-O-DMT-N4-Benzoyl-2'-Deoxycytidine-CE Phosphoramidite DMT-dC(Bz)-CE N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide dC(Bz) CE Phosphoramidite 5'-O-DMT-N4-Benzoyl-2'-Deoxy Cytidine-3’-Cyanoethyl Phosphoramidite deoxy N-Bz Cytidine Amidite DMT-dC(Bz)-CE Amidites N -Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-cyanoethyl-N,N-diisopropylphosphoramidite(DMT-dC(bz)phosphoramidite)(Ac-dC phosphoramidite) DMTr-dC(Bz)-3'-CE-Phosphoramidite Bz dC Beta-Cyanoethyl Phosphoramidite (500 mg) (5'-O-Dimethoxytrityl-N4-benzoyl-2'-deoxycytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite) N-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-2-oxo-pyrimidin-4-yl]benzamide 102212-98-6 C46H52N5O8P