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Memantine HCl

Description References
Memantine HCl
Memantine HCl structure
CAS No.
41100-52-1
Chemical Name:
Memantine HCl
Synonyms
D-145;Axura;Ebixa;Ebixia;Ebixza;Namenda;AKATINOL;Memantin;SUN-Y-7017;MemantinHCl
CBNumber:
CB9232635
Molecular Formula:
C12H22ClN
Formula Weight:
215.76
MOL File:
41100-52-1.mol

Memantine HCl Properties

Melting point:
292 °C
storage temp. 
Inert atmosphere,2-8°C
form 
Fine Powder
color 
White
Merck 
14,5806
CAS DataBase Reference
41100-52-1(CAS DataBase Reference)
FDA UNII
JY0WD0UA60
NCI Dictionary of Cancer Terms
memantine hydrochloride; Namenda
NCI Drug Dictionary
memantine hydrochloride
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Safety Statements  24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29213000

Memantine HCl price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M9292 Memantine hydrochloride ≥98% (GC) 41100-52-1 25mg $63.3 2021-03-22 Buy
Sigma-Aldrich 1380502 Memantine hydrochloride United States Pharmacopeia (USP) Reference Standard 41100-52-1 150mg $366 2021-03-22 Buy
TCI Chemical D3608 3,5-Dimethyl-1-adamantanamine Hydrochloride >98.0%(N)(T) 41100-52-1 5g $29 2021-03-22 Buy
TCI Chemical D3608 3,5-Dimethyl-1-adamantanamine Hydrochloride >98.0%(N)(T) 41100-52-1 25g $86 2021-03-22 Buy
Alfa Aesar J63830 Memantine hydrochloride 41100-52-1 50mg $101 2021-03-22 Buy

Memantine HCl Chemical Properties,Uses,Production

Description

Memantine HCl is the HCl form of Memantine. Memantine is a well- known neuroprotective drug used for the treatment of Alzheimer’s disease. It is believed to be the first neuroprotective drug that has achieve clinical approval by US FDA as well as European. The development of Alzheimer’s disease involves the misfolded mutant proteins such as β-amyloid peptide (Aβ, particularly Aβ1−42). These misfolded mutant protein can increase the NMDA response and further cause severe excitotoxicity. Memantine suppresses this process through acting as the antagonist of the N-methyl-d- aspartate-sensitive glutamate receptor (NMDARs). Memantine is also under investigation as a potential treatment for other kind of neurodegenerative disorders such as HIV-associated dementia, neuropathic pain, glaucoma, depression, Huntington’s disease, ALS and movement disorders, among other.

References

Reisberg, Barry, et al. New England Journal of Medicine 348.14 (2003): 1333-1341.
Lipton, Stuart A. Nature reviews Drug discovery 5.2 (2006): 160-170.

Description

Memantine, a NMDA receptor antagonist, was co-developed by Forest Laboratories with Merz Pharmaceuticals and marketed under the trade name Namenda for the treatment of Alzheimer’s disease in the US after its approval in October, 2003. This drug has been available in many European and Asian markets before getting approval in the US.

Chemical Properties

Crystalline Solid

Uses

Used as an antiparkinsonian and antispasmodic

Uses

Antiparkinsonian;Dopaminergic agonist

Uses

Anti Alzheimer's

Definition

ChEBI: A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.

brand name

Namenda(Forest).

Chemical Synthesis

Memantine (XV) or 1-amino- 3,5-dimethyladamantane hydrochloride was first synthesized by Lilly as an anti-diabetic agent but was ineffective in lowering blood sugar. Several syntheses have been detailed in the literature. However the simplest synthesis of the drug was done in one step from the commercially available 3,5-dimethyl adamantine (122). Treatment of 122 with nitrogen trichloride (CAUTION: very explosive gas!) in the presence of aluminum trichloride (ratio of 1.5:1.2) gave the desired amino adamantine in 86% yield. However, a much safer alternative has been reported by Lilly scientists. Heating the commercially available 3,5-dimethyladamantane 122 in bromine gave the bromo derivative 123 (86%) which was then reacted with sulfuric acid in acetonitrile to provide quantitatively acetyl amino derivative 124 after aqueous workup. Hydrolysis of the acetyl group was done by heating 124 with sodium hydroxide in diethylene glycol to give 1-amino -3,5- adamantane (96%), which was then made into the hydrochloride salt in ether and recrystallized from ether and alcohol mixture to provide the final product memantine hydrochoride XV.

Memantine HCl Preparation Products And Raw materials

Raw materials

Preparation Products


Memantine HCl Suppliers

Global( 482)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Yirun Sega Biological Technology Co. Ltd
19932103556 +8619932103556
+8619932103556 linda@yrsjbiotech.com CHINA 774 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1010 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29959 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58

View Lastest Price from Memantine HCl manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-21 Memantine hydrochloride
41100-52-1
US $100.00-119.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-10-20 Memantine HCl
41100-52-1
US $50.00-38.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-11 memantine hydrochloride
41100-52-1
US $0.00 / KG 1KG 99% 20ton Hebei Mojin Biotechnology Co., Ltd

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