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HL 725

HL 725 structure

CAS No.: 78416-81-6

Chemical Name:: HL 725

Synonyms: HL 725;HL 725 HCL;TREQUINSIN;Trequinsin, HCl;TREQUINSIN HYDROCHLORIDE;Riluzole Impurity 13-13C;DTCZZBVPTHVXFA-OSMRDGEFSA-N;TREQUINSIN HYDROCHLORIDE MINIMUM 98%;4,6-trimethylphenyl)imino)--2-((monohydrochloride;Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem

CBNumber:: CB9238844

Molecular Formula:: C24H28ClN3O3

Molecular Weight:: 441.95

MDL Number:: MFCD01076563

MOL File:: 78416-81-6.mol

Last updated:2023-06-30 15:45:59

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HL 725 Properties

Melting point	210-211 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7))
storage temp.	Desiccate at RT
solubility	DMSO: 100 mM; Ethanol: 100 mM
form	Pale yellow solid
FDA UNII	739I2958C1

SAFETY

Risk and Safety Statements

WGK Germany	3
RTECS	UW7727000

HL 725 price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T2057	Trequinsin hydrochloride ≥98%	78416-81-6	10mg	$245.4	2024-03-01	Buy
Sigma-Aldrich	382425	Trequinsin, Hydrochloride	78416-81-6	10mg	$390	2024-03-01	Buy
Cayman Chemical	17217	Trequinsin (hydrochloride) ≥98%	78416-81-6	1mg	$44	2024-03-01	Buy
Cayman Chemical	17217	Trequinsin (hydrochloride) ≥98%	78416-81-6	5mg	$193	2024-03-01	Buy
Cayman Chemical	17217	Trequinsin (hydrochloride) ≥98%	78416-81-6	10mg	$278	2024-03-01	Buy

Product number	Packaging	Price	Buy
T2057	10mg	$245.4	Buy
382425	10mg	$390	Buy
17217	1mg	$44	Buy
17217	5mg	$193	Buy
17217	10mg	$278	Buy

HL 725 Chemical Properties,Uses,Production

Uses

Trequinsin Hydrochloride is an ultrapotent inhibitor of phosphodiesterase (PDE) 3.

Uses

PDE inhibitor

Biological Activity

Extremely potent inhibitor of cGMP-inhibited phosphodiesterase (PDE3; IC 50 = 250 pM). Potently inhibits arachidonic acid-induced aggregation of human platelets (IC 50 = 50 pM). Orally active antihypertensive agent; reduces systemic blood pressure in both normotensive and hypertensive animal models.

storage

Desiccate at RT

HL 725 Preparation Products And Raw materials

Raw materials

Preparation Products

HL 725 Suppliers

Global( 40)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Shanghai TaoSu Biochemical Technology Co., Ltd.	021-33632979	info@tsbiochem.com	China	8073	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2983	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Shanghai TaoSu Biochemical Technology Co., Ltd.	58
EMMX Biotechnology LLC	60
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Rechem science Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
MedBioPharmaceutical Technology Inc	58
Energy Chemical	58

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4,6-trimethylphenyl)imino)--2-((monohydrochloride 4h-pyrimido(6,1-a)isoquinolin-4-one,2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl HL 725 HL 725 HCL 2,3,6,7-TETRAHYDRO-9,10-DIMETHOXY-3-METHYL-2-[(2,4,6-TRIMETHYLPHENYL)IMINO]-4H-PYRIMIDO[6,1-A]ISOQUINOLIN-4-ONE HYDROCHLORIDE 9,10-DIMETHOXY-2-MESITYLIMINO-3-METHYL-2,3,6,7-TETRAHYDRO-4H-PYRIMIDO-(6,1-A)-ISOQUINOLIN-4-ONE, HCL 9,10-DIMETHOXY-2-MESITYLIMINO-3-METHYL-2,3,6,7-TETRAHYDRO-4H-PYRIMIDO-[6,1A]-ISOQUINOLIN-4-ONE HYDROCHLORIDE TREQUINSIN HYDROCHLORIDE MINIMUM 98% TREQUINSIN TREQUINSIN HYDROCHLORIDE Trequinsin, HCl 4H-Pyrimido(6,1-A)isoquinolin-4-one, 2,3,6,7-tetrahydro-9,10-dimethoxy-3-methyl-2-((2,4,6-trimethylphenyl)imino)-, monohydrochloride 2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-onehydrochloride Trequinsin, Hydrochloride - CAS 78416-81-6 - Calbiochem DTCZZBVPTHVXFA-OSMRDGEFSA-N Riluzole Impurity 13-13C 78416-81-6 C24H27N3O3HCl C24H27N3O3 Cyclic Nucleotide Metabolism G Proteins and Cyclic Nucleotides Phosphodiesterase Inhibitors BioChemical Cell Signaling and Neuroscience Cell Biology