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Abstract Extraction Natural occurance Synthetic method Pharmacological effects
Hyperoside structure
Chemical Name:
HYPERIN;actoside;HYPEROSID;hyperasid;HYPEROSIDE;hyperozide;HYPEROSIDE(P);HYPEROSIDE hplc;Quercetin 3-D-g;Quercetin 3-D-gaL
Molecular Formula:
Formula Weight:
MOL File:

Hyperoside Properties

Melting point:
Boiling point:
872.6±65.0 °C(Predicted)
1.87±0.1 g/cm3(Predicted)
storage temp. 
CAS DataBase Reference
482-36-0(CAS DataBase Reference)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-40
Safety Statements  22-45-36-24/25
WGK Germany  3
RTECS  DJ3009200
HS Code  29389090

Hyperoside price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00180585 Hyperoside primary reference standard 482-36-0 25mg $454 2021-03-22 Buy
Sigma-Aldrich PHR2691 Hyperoside Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100?mg 482-36-0 100MG $699 2021-03-22 Buy
Sigma-Aldrich 1335202 Hyperoside United States Pharmacopeia (USP) Reference Standard 482-36-0 50mg $1680 2021-03-22 Buy
Cayman Chemical 18648 Quercetin 3-D-galactoside ≥98% 482-36-0 1mg $25 2021-03-22 Buy
Cayman Chemical 18648 Quercetin 3-D-galactoside ≥98% 482-36-0 5mg $113 2021-03-22 Buy

Hyperoside Chemical Properties,Uses,Production


Hyperoside is an active ingredient of traditional Chinese medicine extracted from Hypericum perforatum. Modern pharmacological studies have shown that it has a strong analgesic effect, and it could protect the heart, brain, liver, anti-myocardial hypoxia damage and protect cerebral ischemic injury. In recent years, the development of hypericin for the treatment of depression, hepatitis B and other diseases has become a hotspot both in domestic and foreign research.


1.  According to Zhongcheng Ke and others, the volume fraction of ethanol, the ratio of material to liquid and the extraction time were independent variables, the extraction rate of hyperoside was the dependent variable, Through the regression of the independent variables and the dependent variables, extraction technology is screened by response surface method predict the best extraction conditions. The results showed that the extraction process was 11.0 times the amount of 77.6% ethanol, and twice with each for 2.7 h.
2.  According to Zhuoheng Li and others, taking ethanol concentration, ethanol addition factor, extraction temperature and extraction times as the influencing factors, using the extraction rate of hyperoside as an index, the orthogonal experiment was used to optimize the optimum conditions of hyperoside ethanol extraction. The optimum extraction process is 20 times the amount of 60% ethanol, and 4 times at 90 ℃ with each for 2 h. The method is simple, accurate and reproducible.

Natural occurance

Hyperoside is an important natural substance extracted from the dried flowers of the mallow leaves. It is a pale yellow needle-like crystal, and soluble in ethanol, methanol, acetone and pyridine, and stable usually. It could react with hydrochloric acid-magnesium powder to generate cherry red material.
Hyperoside is a flavonol glycoside compound. Hyperoside also has a strong role in inhibiting oogidity reductase, and may be beneficial to the prevention of diabetic cataracts.

Synthetic method

Hyperoside is a natural extract and can also be synthesized now. For the synthesis process, re-read the relevant literature to add. Rutin was used as raw material to obtain hyperoside by benzylation, acid hydrolysis, glycoside condensation through phase transfer catalyzing, deacetylation and debenzylation.
synthetic route of hyperoside

Pharmacological effects


Hypericin, which is widely found in various plants, such as Hypericum, Rosaceae, Campanulaceae, Labiatae, Rhododendron, Asteraceae Kwai, Garciniaceae, Leguminosae, Euonymus, and other fruits and whole grass, is a flavonoid compound.

Chemical Properties

Yellow Solid

Physical properties

Appearance: yellowish needlelike crystals. Melting point: 227–229 °C. Specific optical rotation: ?83° (c = 0.2, pyridine). Solubility: soluble in ethanol, methanol, acetone, and pyridine. Hydrochloric acid–magnesium powder reaction yielded formation of cherry red; ferric chloride reaction was green; α-naphthol reaction was positive.


In 1960, Nair et al. isolated hyperin from redosier dogwood, in which its content is 0.075%. Flavonoids in the treatment of cardiovascular and cerebrovascular diseases play a pivotal role, among which rutin is a typical representative. Isoquetin mainly presents in the leaves of kumquat flowers and the oleander plant kenaf, and it can also be obtained by chemical synthesis. It shows an anti-inflammatory effect through the capillary permeability test and other animal experiments. It also has a toxic effect on the larvae of Chilohabala larvae. It is one of the active ingredients of Hypericum japonicum, which is used in the treatment of hepatitis because of its inhibition of the activities of hepatic enzyme.


A major flavonoid in apple peels; a bioactive constituent of apple peels


This product is available in the British Pharmacopoeia (2017) and the European Pharmacopoeia (9.0th ed.).
Monomeric compounds are currently used clinically. In clinical practice, hypericin is the main active ingredient of proprietary Chinese medicines, such as Acanthopanax capsules, of which Acanthopanax stem and leaf extract are the raw materials for the preparation. Xin’an capsules, prepared with hawthorn leaf extract, are rich in flavonoids, in which hyperoside, a kind of flavonoid, is one of the main components. Qi yue lipid-lowering tablets are prepared from the effective parts of Chinese medicinal herbs such as hawthorn (Nucleation) and Astragalus membranaceus. Flavonoid is one of the main active ingredients in hawthorn, in which hyperoside content is higher. Xinxuening tablets, containing ursolic acid, vitexin rhamnoside, hyperoside, citric acid, and others, is a preparation made from hawthorn and pueraria and other traditional Chinese medicines, in which hawthorn enhances the actions of the medicine. Clinical indications of Xinxuening tablets are coronary heart disease, angina pectoris, chest tightness, palpitations, high blood pressure, arrhythmia, hyperlipidemia, and mental depression.


ChEBI: A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.


Hyperoside has a protective effect against myocardial ischemia. It achieves its protective effect on the myocardium by reducing the apoptosis rate of myocardial cells, inhibiting myocardial cell lactate dehydrogenase release, enhancing anti-freeradical effect , and inhibiting calcium influx so as to .
Hyperoside has a protective effect against cerebral ischemia. Hyperoside can significantly lower oxygen-free radicals, reduce the content of malondialdehyde and NO in brain tissue, inhibit the decrease of the activity of LDH, SOD and glutathione peroxidase, and hence result in reduced brain energy, and improve the antianoxic ability . At the same time, hyperoside can reduce the degree of cerebral edema in ischemia-reperfusion rats .
Hypericin has a significant local analgesic effect that is weaker than that of morphine and stronger than that of aspirin and does not create dependency; it is a new type of local analgesic. Studies have shown that the analgesic effect of hyperoside occurs by reducing the Ca2 + of the pain nerve, thereby inhibiting high potassium-induced Ca2 + influx, which distinguishes it from morphine and aspirin .
Hyperoside has a significant anti-inflammatory effect and a strong cough effect and inhibits the role of eye aldose reductase, which may be beneficial for the prevention of diabetic cataracts. Hypericin has an obvious protective effect on liver tissue and gastric mucosa , and its mechanism is related to antioxidant activity and the promotion of a normal return of NO level and improvement of SOD activity.
Hyperoside significantly enhances immune function. In vivo, hyperoside has a significant inhibitory effect on spleen B, T lymphocyte proliferation and peritoneal macrophage phagocytosis, and mouse thymus index; in vitro hyperoside, at a concentration of 6.25–100 μg/mL, significantly enhanced B, T lymphocyte proliferation and promoted the production of interleukin 2 in T lymphocytes .
In addition, hypericin still has hypolipidemic and antidepressant pharmacological effects. Its derivative rutin has anti-inflammatory and antiviral effects. Another derivative, quercetin, is effective at inhibiting expectorant, cough, and asthma for use in the treatment of chronic bronchitis, coronary heart disease, and hypertension.

Hyperoside Preparation Products And Raw materials

Raw materials

Preparation Products

Hyperoside Suppliers

Global( 285)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
career henan chemical co
+86-371-86658258 CHINA 29959 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086 CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897 CHINA 2712 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 5508 58
Chongqing Chemdad Co.,Ltd
+86-19923101450 CHINA 4000 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037 CHINA 3000 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202 CHINA 372 58

View Lastest Price from Hyperoside manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-28 Hyperoside 482-36-0
US $21.50 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-09-24 Hyperoside
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2021-09-14 Hyperoside
US $64.00 / g/ml 20g/ml 99% 1kg Baoji Guokang Healthchem co.,ltd

Hyperoside Spectrum

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