Ethyl diazoacetate
- CAS No.
- 623-73-4
- Chemical Name:
- Ethyl diazoacetate
- Synonyms
- Ethyl 2-diazoacetate;Daae;Diazoacetic ester;Ethyl diazoate;diazoaceticester;diazoacetate soL;ETHYL DIAZOACETATE;Ethyl diazoethanoate;Ethylene Diazo Acetate;Diazoacetic acid ethyl
- CBNumber:
- CB9241343
- Molecular Formula:
- C4H6N2O2
- Molecular Weight:
- 114.1
- MDL Number:
- MFCD00001989
- MOL File:
- 623-73-4.mol
- MSDS File:
- SDS
| Melting point | -22 °C (lit.) |
|---|---|
| Boiling point | 140-141 °C/720 mmHg (lit.) |
| Density | 1.085 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 115 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Soluble), Hexane (Slightly), Methanol (Slightly) |
| form | Oil |
| color | Light Yellow to Orange |
| Merck | 13,3021 |
| BRN | 107654 |
| EWG's Food Scores | 1 |
| FDA UNII | N84B835FMR |
| NIST Chemistry Reference | Ethyl diazoacetate(623-73-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H226-H242-H302-H315-H319-H351 |
| Precautionary statements | P210-P301+P312-P303+P361+P353-P308+P313-P370+P378-P403+P235 |
| Hazard Codes | Xn,F |
| Risk Statements | 5-10-22-40-67-65-48/20-38-11-63 |
| Safety Statements | 36/37-62-16 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | AG5775000 |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 29270000 |
Ethyl diazoacetate price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | E22201 | Ethyl diazoacetate contains ≥13 wt. % dichloromethane | 623-73-4 | 5g | $34.3 | 2024-03-01 | Buy |
| Sigma-Aldrich | E22201 | Ethyl diazoacetate contains ≥13 wt. % dichloromethane | 623-73-4 | 1kg | $1730 | 2024-03-01 | Buy |
| Sigma-Aldrich | 752150 | Ethyl diazoacetate solution 15% in toluene | 623-73-4 | 25ML | $28.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 752150 | Ethyl diazoacetate solution 15% in toluene | 623-73-4 | 100ML | $73.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | E22201 | Ethyl diazoacetate contains ≥13 wt. % dichloromethane | 623-73-4 | 20g | $101 | 2024-03-01 | Buy |
Ethyl diazoacetate Chemical Properties,Uses,Production
Synthesis
Glycine ethyl ester hydrochloride can be dissolved in a buffer solution composed of acetic acid and sodium acetate, and then dichloroethane is added as a solvent, and sodium nitrite solution is added dropwise at 10 to 15 ° C. After the dropwise addition, continue stirring for 15min. The separated organic layer is a dichloroethane solution of ethyl diazoacetate.
NH2CH2COOC2H5·HCl+NaNO2+HCl→N2CHCOOC2H5+NaCl+H2O
Chemical Properties
Liquid.
Uses
Reagent for ruthenium-catalyzed asymmetric cyclopropanation of alkenes.1
Uses
Hazard
Flammable liquid that explodes when heated.
Safety Profile
Poison by ingestion and intravenous routes. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Can explode. Explodes on contact with tris(dimethy1amino) antimony. When heated to decomposition it emits toxic fumes of NOx. See also ESTERS.
Purification Methods
It is a very volatile yellow oil with a strong pungent odour. EXPLOSIVE [distillation even under reduced pressure is dangerous and may result in an explosion — TAKE ALL THE NECESSARY PRECAUTIONS IF DISTILLATION IS TO BE CARRIED OUT]. It explodes in contact with conc H2SO4-trace acid causes rapid decomposition. It is slightly soluble in H2O, but is miscible with EtOH, *C6H6, pet ether and Et2O. To purify, dissolve it in Et2O [using CH2Cl2 instead of Et2O, protects the ester from acid], wash it with 10% aqueous Na2CO3, dry (MgSO4), filter and repeat as many times as possible until the Et2O layer loses its yellow colour, then remove the solvent below 20o (vacuum). Note that prolonged heating may lead to rapid decomposition and low yields. It can also be purified by steam distillation under reduced pressure but with considerable loss in yield. Place the residual oil in a brown bottle, keep below 10o, and use as soon as possible without distilling. For preparing esters usually the ethereal solution is used directly without purification. [Womack & Nelson Org Synth Coll Vol III 392 1955, UV: Miller & White J Am Chem Soc 79 5974 1957, Fieser 1 367 1967, Beilstein 3 IV 1495.]
Ethyl diazoacetate Preparation Products And Raw materials
Raw materials
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3586 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
View Lastest Price from Ethyl diazoacetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-07-02 | Ethyl diazoacetate
623-73-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2020-01-14 | Ethyl Diazoacetate
623-73-4
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-08-06 | Ethyl diazoacetate
623-73-4
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
-
- Ethyl diazoacetate
623-73-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Ethyl Diazoacetate
623-73-4
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Ethyl diazoacetate
623-73-4
- US $5.00 / KG
- 99%
- Career Henan Chemical Co