Dopamine hydrochloride
- CAS No.
- 62-31-7
- Chemical Name:
- Dopamine hydrochloride
- Synonyms
- DOPAMINE HYDROCHLORIDE;DOPAMINE HCL;2-(3,4-DIHYDROXYPHENYL)ETHYLAMINE HYDROCHLORIDE;ASL-279;intropin;Dopamin Hcl;dopaminechloride;DOPAMINE HCL(RG);Dopamine solution;3-Hydroxytyramine, HCl
- CBNumber:
- CB9243534
- Molecular Formula:
- C8H12ClNO2
- Molecular Weight:
- 189.64
- MDL Number:
- MFCD00012898
- MOL File:
- 62-31-7.mol
| Melting point | 248-250 °C(lit.) |
|---|---|
| Density | 1.4 g/cm3 |
| Flash point | 11℃ |
| storage temp. | Store below +30°C. |
| solubility | alcohol: 20 mg/mL |
| form | Crystalline Powder |
| color | light tan |
| Water Solubility | soluble |
| Sensitive | Air & Light Sensitive |
| Merck | 14,8462 |
| BRN | 3656720 |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| InChIKey | CTENFNNZBMHDDG-UHFFFAOYSA-N |
| CAS DataBase Reference | 62-31-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 7L3E358N9L |
| EPA Substance Registry System | 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (62-31-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xi,N,Xn,T,F | |||||||||
| Risk Statements | 36/37/38-50/53-22-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-61-45-36/37-16 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | UX1092000 | |||||||||
| F | 8-10-23 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29222900 | |||||||||
| Toxicity | LD50 orally in Rabbit: 2859 mg/kg | |||||||||
| NFPA 704 |
|
Dopamine hydrochloride price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D-081 | Dopamine hydrochloride solution 1.0?mg/mL in methanol with 5% 1 M HCl (as free base), ampule of 1?mL, certified reference material, Cerilliant? | 62-31-7 | 1mL | $85.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP468 | Dopamine hydrochloride British Pharmacopoeia (BP) Reference Standard | 62-31-7 | 100MG | $255 | 2024-03-01 | Buy |
| Sigma-Aldrich | 43658 | Dopamine hydrochloride certified reference material, TraceCERT | 62-31-7 | 50mg | $189 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1225204 | Dopamine hydrochloride United States Pharmacopeia (USP) Reference Standard | 62-31-7 | 200mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.22073 | 3-Hydroxytyraminium chloride forsynthesis | 62-31-7 | 10g | $43.5 | 2022-05-15 | Buy |
Dopamine hydrochloride Chemical Properties,Uses,Production
Description
Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D1-5). Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes. Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.
Chemical Properties
Dopamine hydrochloride is designated chemically as 3,4-dihydroxyphenethylamine hydrochloride, a white crystalline powder freely soluble in water. It can also be dissolved in hot 95% ethanol, methanol, and sodium hydroxide solution. However, it is insoluble in chloroform, ether, and benzene. It has no odor and a slightly bitter taste. Dopamine (also referred to as 3-hydroxytyramine) is a naturally occurring biochemical catecholamine precursor of norepinephrine.
Uses
Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive.
Uses
A neurotransmitter and vasopressor that modulates cortical activation. Dopamine hydrochloride is a vasopressor that moderates cortical activation. It is used as a precursor to norepinepherine and epinephrine. It is an important neurotransmitter and chemical messenger that helps in the transmission of signals in the brain and other vital areas.
Uses
dopaminergic: Dopamine (DA) works as neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. Absence of DA-containing neurons is associated with parkinson′s disease.
Indications
Dopamine HCl is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure.
Application
Dopamine hydrochloride has been used to study dopamine-mediated transient modulation of the physiological responses in whiteleg shrimp, Litopenaeus vannamei.
It has been used to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
It has been used to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an 'in vitro' model of parkinsonian Huntington's Disease.
Preparation
Dopamine hydrochloride is produced through the ring-opening reaction of piperonyl ethylamine. Piperethylamine and phenol are added to a reaction vessel and cooled down. Hydrochloric acid is slowly added while heating up the mixture to 110°C, and refluxed for 12-44 hours until the reaction reaches completion. The solution is then slightly cooled and water is added, and the mixture is stirred well and allowed to separate into layers. The upper phenolic layer is then removed, and the aqueous layer is extracted with isopropyl acetate. The extracted aqueous layer is then evaporated under reduced pressure (8.0kPa) until dry. Half the amount of ethanol and hydrochloric acid are added to the dry residue and heated to dissolve. The solution is then cooled, crystallized, and filtered. The filter cake is washed with ethanol and dried to obtain the final product, with a yield of 74%.
Definition
ChEBI: Dopamine hydrochloride is a catecholamine.
brand name
Intropin (Mayne).
General Description
Dopamine Hydrochloride is the hydrochloride salt form of dopamine, a monoamine compound with positive inotropic activity. Dopamine is a neurotransmitter which is a naturally occurring catecholamine. Dopamine hydrochloride salt is indicated as a medicine for the treatment of acute congestive and renal failures.
Biological Activity
Endogenous neurotransmitter that acts as an agonist at dopamine D 1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.
Pharmacokinetics
Dopamine hydrochloride(62-31-7) is a precursor for the synthesis of epinephrine in the body. It has β (mainly β1 receptor) receptor agonism and α receptor agonism, and can also promote the release of norepinephrine. It can enhance myocardial contractility, increase cardiac output, and accelerate the heart rate to a lesser extent (not as obvious as isoproterenol); stimulate the α-receptors of blood vessels in tissues such as skin and muscles, so that blood vessels constrict and blood supply is reduced; it stimulates visceral blood vessels ( The dopamine receptors in the kidney, mesentery, and heart) dilate and increase blood flow. The change of total peripheral resistance is not obvious, but it is beneficial to improve the blood supply of vital organs during shock.
Clinical Use
Cardiogenic shock in infarction or cardiac surgery
target
Dopamine Receptor
Drug interactions
Potentially hazardous interactions with other drugs
Alpha-blockers: avoid with tolazoline.
Anaesthetics: risk of ventricular arrhythmias with
isoflurane - avoid.
Antidepressants: risk of hypertensive crisis with
MAOIs and moclobemide.
Ciclosporin: may reduce risk of ciclosporin
nephrotoxicity
Dopaminergics: effects possibly enhanced
by entacapone; avoid with rasagiline; risk of
hypertensive crisis with selegiline.
Metabolism
Dopamine is a metabolic precursor of noradrenaline and, whereas a proportion is excreted as the metabolic products of noradrenaline, the majority is mainly metabolised into 3,4,-dihydroxyphenylacetic acid (DOPAC) and 3-methoxy-4-hydroxyphenylacetic (HVA) which are rapidly excreted in the urine.
storage
Store at -20°C
Dopamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2118 | 58 |
| Henan Tengmao Chemical Technology Co. LTD | +8615238638457 | salesvip2@hntmhg.com | China | 415 | 58 |
| Hebei Jingbo New Material Technology Co., Ltd | +8619931165850 | hbjbtech@163.com | China | 1000 | 58 |
| ARCTIC EXPORTS INC | +1-3026880818 +1-3026880818 | ARCTICEXPORTSINC@GMAIL.COM | Canada | 67 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7377 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 224 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
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View Lastest Price from Dopamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | 3-Hydroxytyramine hydrochloride
62-31-7
|
US $20.00 / kg | 1kg | 99% | 300tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-04-15 | Dopamine hydrochloride
62-31-7
|
US $25.00 / kg | 1kg | 99% | 50000tons | Wuhan Boyuan Import & Export Co., LTD | |
 |
2024-04-11 | Dopamine hydrochloride
62-31-7
|
US $0.00 / kg | 1kg | 99.8% | 1000 kg | BINBO BIOLOGICAL CO.,LTD |
-
- 3-Hydroxytyramine hydrochloride
62-31-7
- US $20.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
-
- Dopamine hydrochloride
62-31-7
- US $25.00 / kg
- 99%
- Wuhan Boyuan Import & Export Co., LTD
-
- Dopamine hydrochloride
62-31-7
- US $0.00 / kg
- 99.8%
- BINBO BIOLOGICAL CO.,LTD