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BX-912

BX-912 structure

CAS No.: 702674-56-4

Chemical Name:: BX-912

Synonyms: BX 912;CS-339;BX912/BX-912;BX-912, >=98%;Apoptosis,PDK-1,inhibit,BX912,BX-912,Inhibitor,BX 912;N-(3-((4-((2-(1H-Imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-c;N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide;N-[3-[[4-[[2-(4-Imidazolyl)ethyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide;N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide;N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide

CBNumber:: CB92454082

Molecular Formula:: C20H23BrN8O

Molecular Weight:: 471.35

MDL Number:: MFCD10565925

MOL File:: 702674-56-4.mol

Last updated:2023-06-08 09:02:14

Request For Quotation

BX-912 Properties

Density	1.596
storage temp.	-20°C
solubility	≥23.55 mg/mL in DMSO; insoluble in H2O; ≥10.25 mg/mL in EtOH
form	powder
color	white to beige
FDA UNII	Y7RG737FY6

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

WGK Germany

NFPA 704

	0
2		0

BX-912 price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML1086	BX-912 ≥95% (HPLC)	702674-56-4	5mg	$106	2024-03-01	Buy
Sigma-Aldrich	SML1086	BX-912 ≥95% (HPLC)	702674-56-4	25mg	$417	2024-03-01	Buy
Cayman Chemical	14708	BX-912 ≥98%	702674-56-4	1mg	$45	2024-03-01	Buy
Cayman Chemical	14708	BX-912 ≥98%	702674-56-4	5mg	$100	2024-03-01	Buy
Cayman Chemical	14708	BX-912 ≥98%	702674-56-4	10mg	$177	2024-03-01	Buy

Product number	Packaging	Price	Buy
SML1086	5mg	$106	Buy
SML1086	25mg	$417	Buy
14708	1mg	$45	Buy
14708	5mg	$100	Buy
14708	10mg	$177	Buy

BX-912 Chemical Properties,Uses,Production

Description

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. BX-912 is a potent, ATP-competitive inhibitor of PDK1 (IC₅₀ = 26 nM). It less effectively inhibits a panel of related serine-threonine kinases. BX-912 has been used to evaluate the role of PDK1 in kinase activation and cell survival.

Uses

A selective potent PDK-1 inhibitor with an IC50 of 12 nM.

Uses

BX-912 is a selective potent 3-Phosphoinositide-dependent Kinase-1 (PDK1) inhibitor. BX-192 shows potential anticancer properties as it inibits PDK1 activity towards the signaling pathway in cancer cell growth, survival and tumor angiogenesis.

Definition

ChEBI: N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas.

target

PDK-1

References

[1] feldman ri1, wu jm, polokoff ma, kochanny mj, dinter h, zhu d, biroc sl, alicke b, bryant j, yuan s, buckman bo, lentz d, ferrer m, whitlow m, adler m, finster s, chang z, arnaiz do. novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. j biol chem. 2005 may 20;280(20):19867-74. epub 2005 mar 16.

BX-912 Preparation Products And Raw materials

Raw materials

Preparation Products

BX-912 Suppliers

Global( 125)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from BX-912 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	BX-912 702674-56-4	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

BX-912
702674-56-4
US $2.00 / kg
99%
Career Henan Chemical Co

BX-912 Spectrum

BX-912(702674-56-4)¹HNMR

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Olaparib BX-912 (5-BROMO-PYRIMIDIN-2-YL)-PHENYL-AMINE

1of2

1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]- BX 912 PYRROLIDINE-1-CARBOXYLIC ACID (3-(5-BROMO-4-[2-(1H-IMIDAZOL-4-YL)-ETHYLAMINO]-PYRIMIDIN-2-YLAMINO)-PHENYL)-AMIDE N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX912/BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX912/BX-912 N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imid N-(3-((4-((2-(1H-Imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-c N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-912 BX9121-PYRROLIDINECARBOXAMIDE,N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]- BX-912, >=98% CS-339 1-Pyrrolidinecarboxamide, N-[3-[[5-bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]- N-(3-((4-((2-(1H-imidazol-4-yl)ethyl)amino)-5-bromopyrimidin-2-yl)amino)phenyl)pyrrolidine-1-carboxamide N-[3-[[4-[[2-(4-Imidazolyl)ethyl]amino]-5-bromo-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide Apoptosis,PDK-1,inhibit,BX912,BX-912,Inhibitor,BX 912 702674-56-4 C20H23BrN8O Inhibitors Inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1). Akt mTOR PI3K