ChemicalBook >> CAS DataBase List >>Bafetinib
Bafetinib
- CAS No.
- 859212-16-1
- Chemical Name:
- Bafetinib
- Synonyms
- Benil;Ns 187;CS-239;Rhinon;Inno-406;Inno 406;Rinazina;Unii-nvw4Z03I9b;Bafetinib (INNO-406);INNO 406 - Bafetinib
- CBNumber:
- CB92473854
- Molecular Formula:
- C30H31F3N8O
- Molecular Weight:
- 576.62
- MDL Number:
- MFCD18633200
- MOL File:
- 859212-16-1.mol
- MSDS File:
- SDS
Last updated:2023-05-18 11:31:21
| Melting point | 166-168°C |
|---|---|
| Density | 1.36±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | DMSO:42.0(Max Conc. mg/mL);72.84(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.72±0.70(Predicted) |
| FDA UNII | NVW4Z03I9B |
Bafetinib price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19169 | Bafetinib ≥98% | 859212-16-1 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 19169 | Bafetinib ≥98% | 859212-16-1 | 5mg | $118 | 2024-03-01 | Buy |
| Cayman Chemical | 19169 | Bafetinib ≥98% | 859212-16-1 | 10mg | $214 | 2024-03-01 | Buy |
| TRC | B109050 | Bafetinib | 859212-16-1 | 5mg | $90 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180774 | Bafetinib (INNO-406) >98% | 859212-16-1 | 1g | $2172.6 | 2021-12-16 | Buy |
Bafetinib Chemical Properties,Uses,Production
Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia (CML). Bafetinib is a rationally developed tyrosine kinase inhibitor based on the chemical structure of imatinib , with modifications added to improve binding and potency against Bcr-Abl kinase (IC50 = 5.8 nM). It is 25- to 55-fold more potent than imatinib in vitro and ≥10-fold more potent in vivo. Bafetinib inhibits 12 out of the 13 most frequent imatinib-resistant Bcr-Abl point mutations, but not the T315I mutation and also targets the Src family kinase Lyn (IC50 = 19 nM), which has been associated with resistance to imatinib in CML.
Chemical Properties
Pale Yellow Solid
Uses
A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor.
Bafetinib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 109)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from Bafetinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-07 | Bafetinib USP/EP/BP
859212-16-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-07-06 | Bafetinib
859212-16-1
|
US $1.00 / kg | 1kg | 98% | 100KG | Career Henan Chemical Co |
-
- Bafetinib USP/EP/BP
859212-16-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Bafetinib
859212-16-1
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
859212-16-1(Bafetinib)Related Search:
Benzamide, N-(3-((4,5'-bipyrimidin)-2-ylamino)-4-methylphenyl)-4-(((3S)-3-(dimethylamino)-1-pyrrolidinyl)methyl)-3-(trifluoromethyl)-
Inno 406
Inno-406
4-[[(3S)-3-Dimethylaminopyrrolidin-1-yl]methyl]-N-[4-methyl-3-[(4-pyrimidin-5-ylpyrimidin-2-yl)amino]phenyl]-3-(trifluoromethyl)benzamide
Ns 187
Unii-nvw4Z03I9b
Bafetinib (INNO-406)
N-[3-([4,5'-BipyriMidin]-2-ylaMino)-4-Methylphenyl]-4-[[(3S)-3-(diMethylaMino)-1-pyrrolidinyl]Methyl]-3-(trifluoroMethyl)benzaMide
Bafetinib(INNO 406,NS 187)
(S)-N-(3-([4,5'-bipyriMidin]-2-ylaMino)-4-Methylphenyl)-4-((3-(diMethylaMino)pyrrolidin-1-yl)Methyl)-3-(trifluoroMethyl)benzaMide
(S)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-N-(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenyl)-3-(trifluoromethyl)benzamide
Bafetinib N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3-(dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)benzamide
NS-187; BAFETINIB; INNO406
CS-239
INNO 406 - Bafetinib
Benil
Rhinon
Rinazina
(S)-N-(3-([4,5'-Bipyrimidin]-2-ylamino)-4-methylphenyl)-4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)benzamide
859212-16-1
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Heterocycles
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