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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester structure

CAS No.: 3543-74-6

Chemical Name:: 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

Synonyms: Bendamustine USP RC C;Bendamustine Impurity 40;Bendamustine Dihydroxy Ester;Bendamustine Related Impurity 1;Bendamustine Related Compound C;Bendamustine USP Related Compound C;5-[Bis(2-hydroxyethyl)amino]-1-meth;ethyl 4-(5-(bis(2-hydroxyethyl)amino);Bendamustine hydrochloride Intermediates 1;Bendamustine USP RC C /Bendamustine Impurity A

CBNumber:: CB92485093

Molecular Formula:: C18H27N3O4

Molecular Weight:: 349.42

MDL Number:: MFCD09840918

MOL File:: 3543-74-6.mol

MSDS File:: SDS

Last updated:2024-03-28 13:39:29

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5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Properties

Melting point	98-101°C
Boiling point	580.6±50.0 °C(Predicted)
Density	1.21±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.26±0.10(Predicted)
color	White to Brown
FDA UNII	AUL5NUY9I0

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H341-H351-H361fd
Precautionary statements	P201-P202-P264-P270-P280-P301+P310
HS Code	2933998350

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1065254	Bendamustine Related Compound C United States Pharmacopeia (USP) Reference Standard	3543-74-6	20MG	$3470	2024-03-01	Buy
TRC	M294190	[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoicAcidEthylEster	3543-74-6	500mg	$275	2021-12-16	Buy
AK Scientific	J97550	5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoicacidethylester	3543-74-6	5g	$210	2021-12-16	Buy
AK Scientific	J11386	BendamustineImpurity1	3543-74-6	25mg	$49	2021-12-16	Buy
AK Scientific	J11386	BendamustineImpurity1	3543-74-6	100mg	$148	2021-12-16	Buy

Product number	Packaging	Price	Buy
1065254	20MG	$3470	Buy
M294190	500mg	$275	Buy
J97550	5g	$210	Buy
J11386	25mg	$49	Buy
J11386	100mg	$148	Buy

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Chemical Properties,Uses,Production

Chemical Properties

Off-White to Light Tan Solid

Uses

[1-Methyl-5-bis(2’-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester_x000D_Bendamustine Related Impurity 1 (cas# 3543-74-6) is a compound useful in organic synthesis.

Synthesis

Stir and dissolve 5-amino-1-methyl-1H-2-benzimidazole butyric acid ethyl ester (60g, 0.23mol), 600mL water, and 300mL glacial acetic acid in a 2L reaction flask, and cool to -50, Add 120 mL of ethylene oxide, and control the temperature to complete the reaction. Adjust the pH of the potassium carbonate solution to 7.0-7.3, extract with dichloromethane 300 mL×3, combine the organic phases, wash with purified water 200 mL×3, dry with anhydrous magnesium sulfate, filter, and concentrate to obtain a brown solid. Then add 1200 mL of ethyl acetate and heat to 70-80° C. to dissolve, cool to room temperature to crystallize, filter and dry to obtain 63 g of light brown solid 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester with a purity of 99.3%. The yield was 78.5%.

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester synthesis

Synthesis of 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester from ETHYLENE OXIDE and 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Preparation Products And Raw materials

Raw materials

2,2'-[[4-(methylamino)-3-nitrophenyl]imino]bisethanol 1H-Benzimidazole-2-butanoic acid, 5-[bis(2-hydroxyethyl)amino]-2,3-dihydro-2-hydroxy-1-methyl- oxirene 4-(5-amino-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid Pentanoic acid, 5-[(2-fluoro-5-nitrophenyl)amino]-5-oxo-

2-Fluoro-5-nitroaniline 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester 1-Methyl-5-nitro-2-benzimidazolebutyric acid 2,2'-[(4-fluoro-3-nitrophenyl)imino]bisethanol 1-Methyl-5-nitro-1H-benzimidazole-2-butanoic Acid Ethyl Ester

ETHYLENE OXIDE 2-Bromoethanol Ethanol

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Preparation Products

Bendamustine hydrochloride

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester Suppliers

Global( 184)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7786	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Lianyungang happen teng technology co., LTD	15950718863	wang666xt@163.com	CHINA	295	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	925	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Lianyungang happen teng technology co., LTD	58
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Xiamen AmoyChem Co., Ltd	58

View Lastest Price from 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-03-29	5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6	US $32.00-1.30 / kg	1kg	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
	2019-07-06	5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 3543-74-6	US $1.00 / KG	1KG	99%	Customized	Career Henan Chemical Co

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
3543-74-6
US $32.00-1.30 / kg
99%
Henan Fengda Chemical Co., Ltd

5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester
3543-74-6
US $1.00 / KG
99%
Career Henan Chemical Co

3543-74-6(5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester)Related Search:

Bendamustine Impurity 26 FMOC-GLY-GLY-GLY-OH BEPOTASTINE BESILATE 5-alpha-Hydroxy- Laxogenin 1-Methyl-5-amino-1H-benzimidazole-2-butanoic acid ethyl ester

ethyl 4-(1-methyl-5-nitro-1H-benzo[d]imidazol-2-yl)butanoate Bendamustine Desmethyl Impurity Bendamustine Ether Impurity Bendamustine Impurity 28 DesMethyl BendaMustine Hydrochloride

BendaMustine IMpurity B 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid Bendamustine Impurity 8 Bendamustine Impurity D 5-[bis-(2-Chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester

Bendamustine Impurity 14 BendaMustine IMpurity C　　 5-[(2-Chloroethyl)(2-hydroxyethyl)aMino]-1-Methyl-1H-benziMidazole-2-butanoic Acid

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Ethyl-4-(5-(bis(2-hydroxyethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoate 5-[Bis(2-hydroxyethyl)aMino]-1-Methyl-2-benziMidazolebutyric Acid Ethyl Ester 4-[5-[Bis(2-hydroxyethyl)aMino]-1-MethylbenziMidazol-2-yl]butanoic acid ethyl ester ethyl 4-{5-[bis(2-hydroxyethyl)aMino]-1-Methyl-1H-1,3-benzodiazol-2-yl}butanoate Bendamustine Related Impurity 1 1H-Benzimidazole-2-butanoicacid, 5-[bis(2-hydroxyethyl)amino]-1-methyl-, ethyl ester 5-[Bis(2-hydroxyethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid ethyl ester 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acidethylester 1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester 5-(bis(2-hydroxyethyl)amino)-1-methyl-1h-benzimidazole-2-butanoic acid ethyl est Bendamustine hydrochloride Intermediates 1 Bendamustine Dihydroxy Ester [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butanoic Acid Ethyl Ester Bendamustine Related ethyl 4-(5-(bis(2-hydroxyethyl)amino) Bendamustine USP RC C Bendamustine USP Related Compound C Ethyl 4-(5-Bis(2-Hydroxy Ethyl)Amino-1-Methyl-1Hbenzo[D]Imidazole-2-Yl]Butanoate 5-[Bis(2-hydroxyethyl)amino]-1-meth Bendamustine Impurity 40 Bendamustine Related Compound C Bendamustine USP RC C /Bendamustine Impurity A [1-Methyl-5-bis(2'-hydroxyethyl)aminobenzimidazolyl-2]butano... 5-112-hydroxyethyl complex with -1-methyl-1H benzimizole-2-butyrate B chisel Bendamustin Impurity-A (USP related compound C) Ethyl 4-{5-[Bis-(2-hydroxy-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyrate 3543-74-6 543-74-6 intermediate Aromatics Intermediates & Fine Chemicals Pharmaceuticals