4,6-dichloro-2-propylthiopyrimidine-5-amine
- CAS No.
- 145783-15-9
- Chemical Name:
- 4,6-dichloro-2-propylthiopyrimidine-5-amine
- Synonyms
- 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine;oro-2-propyL;Ticagrelor Impurity U;thiopyrimidine-5-amine;Ticagrelor Impurity 110;Tecagrelor InterMediate 3;Ticagrelor Intermediate ide;2-propylthiopyrimidine-5-amine;6-dichloro-2-propylthiopyrimidine-5-amine;4,6-Dichloro-2-(propylthio)pyriMidin-aMine
- CBNumber:
- CB92487693
- Molecular Formula:
- C7H9Cl2N3S
- Molecular Weight:
- 238.14
- MDL Number:
- MFCD16875503
- MOL File:
- 145783-15-9.mol
| Boiling point | 334.1±37.0 °C(Predicted) |
|---|---|
| Density | 1.44 |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to lump to clear liquid |
| pka | -3.46±0.12(Predicted) |
| color | White or colorless to Brown |
| Water Solubility | 100mg/L at 22℃ |
| InChI | InChI=1S/C7H9Cl2N3S/c1-2-3-13-7-11-5(8)4(10)6(9)12-7/h2-3,10H2,1H3 |
| InChIKey | CJJLJBFJNXMANZ-UHFFFAOYSA-N |
| SMILES | C1(SCCC)=NC(Cl)=C(N)C(Cl)=N1 |
| FDA UNII | QY0S1U6LEG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29335990 | |||||||||
| NFPA 704 |
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4,6-dichloro-2-propylthiopyrimidine-5-amine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2716 | 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine >98.0%(GC) | 145783-15-9 | 1g | $58 | 2024-03-01 | Buy |
| TCI Chemical | A2716 | 5-Amino-4,6-dichloro-2-(propylthio)pyrimidine >98.0%(GC) | 145783-15-9 | 5g | $175 | 2024-03-01 | Buy |
| BroadPharm | BP-20662 | 4,6-dichloro-2-(propylthio)pyrimidin-5-amine | 145783-15-9 | 100mg | $180 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD16313 | 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine | 145783-15-9 | 500g | $235 | 2021-12-16 | Buy |
| SynQuest Laboratories | 7H66-5-72 | 4,6-Dichloro-2-(propylsulfanyl)pyrimidin-5-amine 97.0% | 145783-15-9 | 100g | $260 | 2021-12-16 | Buy |
4,6-dichloro-2-propylthiopyrimidine-5-amine Chemical Properties,Uses,Production
Description
4,6-dichloro-2-propylthiopyrimidine-5-amine is a pharmaceutical intermediate used in the preparation of Ticagrelor, which belongs to a class of drugs called antiplatelet agents. It works by preventing platelets (a type of blood cell) from aggregating and forming clots that can lead to heart attacks or strokes.
Chemical Properties
Light pink to dark brown liquid or semi solid
Uses
Intermediate in the preparation of Ticagrelor (T437700) and reversible P2Y12 receptor antagonists.
Synthesis
The synthesis of 4,6-dichloro-2-propylthiopyrimidine-5-amine is as follows：tert-Butyl methyl ether (370 g) was placed under nitrogen in a 1 L stainless steel autoclave equipped with a temperature-controlled jacket, an Ekato InterMIG stirrer, an internal temperature sensor and a dip pipe, and 4,6-dichloro-5-nitro-2-propylsulfanyl-pyrimidine (94.5 g, 0.35 mol) was added and dissolved at a stirring rate of 200 min-1. The catalyst suspension was prepared and transferred into the autoclave as described in the preceding example. The autoclave was sealed and the stirring rate was increased to 600 min-1 while the autoclave was purged four times with nitrogen. Subsequently, hydrogen gas feed via the dip pipe at a constant flow rate (pmax=10 bar) as well as a heating-up ramp (45 K/h) from 20° C. to 65° C. were started in parallel, while stirring at 600 min-1. The progress of the exothermic reaction was followed by recording the hydrogen uptake as well as the internal and jacket temperature curve. Upon completion of the hydrogen uptake (ca. 1.1 mol or 3 molar equivalents) after about 4 h, stirring of the reaction mixture was continued for an additional 3 hours at 65° C. After unloading the autoclave (the reactor was cooled down to 20° C., the hydrogen pressure was released and the reactor purged four times with nitrogen), the catalyst was filtered off. The autoclave as well as the filter cake (catalyst) were washed with tent-butyl methyl ether (185 g). The organic phases were combined and the water layer separated. An IPC-sample was taken to analyze the product mixture. The conversion was found to be quantitative with no nitroso or hydroxylamine intermediate being detectable. 
4,6-dichloro-2-propylthiopyrimidine-5-amine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 | info@rochipharma.com | China | 431 | 58 |
| Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 | sales3@zhhairuide.com | China | 97 | 58 |
| JUYE XIANDAI fine chemistry Co.,Ltd | +8618958038633 | tony@sdhypharma.com | China | 58 | 58 |
| ChemExpress | +86-021-58950125 | info@chemexpress.com | China | 557 | 58 |
| Shanghai Qianyi New Material Co., Ltd. | +8618083322317 | 3391883138@qq.com | China | 878 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +undefined8613073685410 | sales@ichemie.com | China | 985 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
View Lastest Price from 4,6-dichloro-2-propylthiopyrimidine-5-amine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-11-28 | 4,6-dichloro-2-propylthiopyriMidine-5-aMine
145783-15-9
|
US $100.00-500.00 / kg | 1000kg | 99% | 10ton | Shanghai Qianyi New Material Co., Ltd. | |
 |
2023-11-01 | 4,6-dichloro-2-propylthiopyrimidine-5-amine
145783-15-9
|
US $0.00-0.00 / kg | 1kg | 99% | 500KG | Hangzhou ICH Biofarm Co., Ltd | |
 |
2023-09-08 | 4,6-dichloro-2-propylthiopyrimidine-5-amine
145783-15-9
|
US $0.00 / KG Ton | 1KG Ton | 98%+ | 2 tons/month | Zhuhai Hairuide Bioscience and Technology Co., Ltd |
-
- 4,6-dichloro-2-propylthiopyriMidine-5-aMine
145783-15-9
- US $100.00-500.00 / kg
- 99%
- Shanghai Qianyi New Material Co., Ltd.
-
- 4,6-dichloro-2-propylthiopyrimidine-5-amine
145783-15-9
- US $0.00-0.00 / kg
- 99%
- Hangzhou ICH Biofarm Co., Ltd
-
- 4,6-dichloro-2-propylthiopyrimidine-5-amine
145783-15-9
- US $0.00 / KG Ton
- 98%+
- Zhuhai Hairuide Bioscience and Technology Co., Ltd
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