6-METHOXY-2-NAPHTHYLACETIC ACID
- CAS No.
- 23981-47-7
- Chemical Name:
- 6-METHOXY-2-NAPHTHYLACETIC ACID
- Synonyms
- 6-MNA;BRL 10720;Desmethyl Naproxe;DESMETHYL NAPROXEN;α-Demethylnaproxen;Naproxen Impurity I;Naproxen EP impurity I;alpha-Demethylnaproxen;6-metossi-2-naphtilacetico;6-METHOXY-2-NAPHTHYLACETIC ACID
- CBNumber:
- CB9249046
- Molecular Formula:
- C13H12O3
- Molecular Weight:
- 216.23
- MDL Number:
- MFCD00033105
- MOL File:
- 23981-47-7.mol
| Melting point | 170-172°C |
|---|---|
| Boiling point | 408.8±20.0 °C(Predicted) |
| Density | 1.235 |
| RTECS | QJ1045000 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Off-white solid. |
| pka | 4.35±0.30(Predicted) |
| color | Off-White to Yellow |
| FDA UNII | 9H7K3YOD7Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,Xi,N | |||||||||
| Risk Statements | 22-36/37/38-37/38-41-50 | |||||||||
| Safety Statements | 26-39-61 | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
6-METHOXY-2-NAPHTHYLACETIC ACID price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 08137 | 2-(6-Methoxynaphthalen-2-yl)acetic acid pharmaceutical impurity standard | 23981-47-7 | 50mg | $611 | 2024-03-01 | Buy |
| Alfa Aesar | J67138 | 6-Methoxy-2-naphthylacetic acid, 99% | 23981-47-7 | 5mg | $57.65 | 2024-03-01 | Buy |
| Alfa Aesar | J67138 | 6-Methoxy-2-naphthylacetic acid, 99% | 23981-47-7 | 10mg | $108.65 | 2024-03-01 | Buy |
| Cayman Chemical | 70620 | 6-methoxy Naphthalene Acetic Acid ≥99% | 23981-47-7 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 70620 | 6-methoxy Naphthalene Acetic Acid ≥99% | 23981-47-7 | 10mg | $61 | 2024-03-01 | Buy |
6-METHOXY-2-NAPHTHYLACETIC ACID Chemical Properties,Uses,Production
Chemical Properties
Yellow Solid
Uses
A metabolite of Nabumetone. A competitive, non-selective COX inhibitor.
Definition
ChEBI: (6-methoxy-2-naphthyl)acetic acid is a monocarboxylic acid consisting of 2-naphthylacetic acid having a methoxy substituent at the 6-position. The active metabolite of the prodrug nabumetone. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a drug metabolite and a xenobiotic metabolite. It is a monocarboxylic acid and a methoxynaphthalene. It is functionally related to a 2-naphthylacetic acid.
Biological Activity
6-methoxy naphthalene acetic acid is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2][3].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].6-methoxy naphthalene acetic acid (6-mna) is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2]. 6-mna is a metabolite of nebumetome. 6-mna inhibited human recombinant cox-1 and -2 with ic50 values of 70 and 20 μm, respectively [1].
References
[1]. barnett j, chow j, ives d, et al. purification, characterization and selective inhibition of human prostaglandin g/h synthase 1 and 2 expressed in the baculovirus system. biochim biophys acta. 1994 nov 16;1209(1):130-9.
[2]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[3]. laneuville o1, breuer dk, dewitt dl, et al. differential inhibition of human prostaglandin endoperoxide h synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. j pharmacol exp ther. 1994 nov;271(2):927-34.
6-METHOXY-2-NAPHTHYLACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12382 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
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