Sb-742457
- CAS No.
- 607742-69-8
- Chemical Name:
- Sb-742457
- Synonyms
- CS-579;RVT-101;CS-2723;Sb-742457;Sb 742457;Gsk 742457;SB-742457(RVT-101);Sb-742457 USP/EP/BP;SB 742457/GSK 742457;SB742457:Intepirdine
- CBNumber:
- CB92495263
- Molecular Formula:
- C19H19N3O2S
- Molecular Weight:
- 353.44
- MDL Number:
- MFCD12828872
- MOL File:
- 607742-69-8.mol
- MSDS File:
- SDS
| Boiling point | 608.3±45.0 °C(Predicted) |
|---|---|
| Density | 1.292 |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; ≥17.65 mg/mL in DMSO; ≥2.13 mg/mL in EtOH with gentle warming and ultrasonic |
| pka | 8?+-.0.10(Predicted) |
| form | solid |
| FDA UNII | 2IOB2M82HY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Sb-742457 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22200 | SB-742457 ≥98% | 607742-69-8 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 22200 | SB-742457 ≥98% | 607742-69-8 | 5mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 22200 | SB-742457 ≥98% | 607742-69-8 | 10mg | $319 | 2024-03-01 | Buy |
| Cayman Chemical | 22200 | SB-742457 ≥98% | 607742-69-8 | 25mg | $704 | 2024-03-01 | Buy |
| ChemScene | CS-1087 | Intepirdine 98.92% | 607742-69-8 | 100mg | $1100 | 2021-12-16 | Buy |
Sb-742457 Chemical Properties,Uses,Production
Description
SB-742457 is an orally bioavailable antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 1.4 nM). SB-742457 (1 μM) also binds to 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors with high affinity. SB-742457 reduces 5-HT6 activation of Gs-mediated cAMP production in a concentration-dependent manner with an EC50 value of 21 nM in NG108-15 neuroblastoma cells. In vivo, SB-742457 (1.5 mg/kg, p.o.) reverses deficits in novel object recognition induced by scopolamine in rats. It also reverses age-induced impairments in spatial memory acquisition and retention in rats in the Morris water maze. SB-742457 (3.0 mg/kg, i.p.) reduces the number of licking bouts by 24% compared with control in rats trained to lick a glucose solution, indicating a role in satiety and obesity management.
Uses
SB 742457 is a selective 5-HT6 receptor antagonist which is known to be involved in improving cognitive function.
target
5-HT6
References
[1] aaron t. t. chuang, andrew foley, perdita l. pugh, david sunter, xin tong, ciaran regan, lee a. dawson, andrew d. medhurst, neil upton.5-ht6 receptor antagonist sb-742457 as a novel cognitive enhancing agent for alzheimer’s disease. alzheimer's & dementia: the journal of the alzheimer's association volume 2, issue 3, supplement, pages s631–s632, july 2006
Sb-742457 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
