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Paquinimod

Paquinimod Structure
Paquinimod structure
CAS No.
248282-01-1
Chemical Name:
Paquinimod
Synonyms
ABR25757;ABR-25757;ABR 25757;ABR?215757;Paquinimod;ABR?215757; ABR 215757; ABR215757; PAQUINIMOD.;ABR-25757,Inhibitor,ABR25757,inhibit,Paquinimod;ABR 25757;ABR-25757;ABR25757;PAQUINIMOD;248282-01-1;N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide;N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
CBNumber:
CB92498835
Molecular Formula:
C21H22N2O3
Molecular Weight:
350.41
MDL Number:
MFCD18633277
MOL File:
248282-01-1.mol
MSDS File:
SDS
Last updated:2023-09-04 15:51:00
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Paquinimod Properties

Boiling point 487.3±45.0 °C(Predicted)
Density 1.267±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:15.0(Max Conc. mg/mL);42.8(Max Conc. mM)
form A solid
pka 4.50±1.00(Predicted)
FDA UNII HB76GLG27V

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

Paquinimod price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 28443 Paquinimod 248282-01-1 1mg $55 2024-03-01 Buy
Cayman Chemical 28443 Paquinimod 248282-01-1 25mg $914 2024-03-01 Buy
Cayman Chemical 28443 Paquinimod 248282-01-1 5mg $224 2024-03-01 Buy
Cayman Chemical 28443 Paquinimod 248282-01-1 10mg $420 2024-03-01 Buy
AK Scientific 1997DM Paquinimod 248282-01-1 5mg $146 2021-12-16 Buy
Product number Packaging Price Buy
28443 1mg $55 Buy
28443 25mg $914 Buy
28443 5mg $224 Buy
28443 10mg $420 Buy
1997DM 5mg $146 Buy

Paquinimod Chemical Properties,Uses,Production

Uses

Paquinimod is a S100A9 inhibitor preventing S100A9 binding to TLR-4. Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Paquinimod treatment of collagenase-induced OA (CIOA) resulted in significantly reduced synovial thickening (57%), osteophyte size at the medial femur (66%) and cruciate ligaments (67%) and cartilage damage at the medial tibia (47%) and femur (75%; n=7, untreated n=6). Paquinimod reduces leukocyte recruitment during sterile inflammation. Paquinimod also reduced priming of proinflammatory effector CD4(+) T cells.

Paquinimod synthesis

1354639-60-3
103-69-5
248282-01-1
Synthesis of Paquinimod from methyl 5-ethyl-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate and N-Ethylaniline

Paquinimod Preparation Products And Raw materials

Raw materials

34934-06-0 3-?Quinolinecarboxylic acid, 5-?ethyl-?1,?2-?dihydro-?4-?hydroxy-?1-?methyl-?2-?oxo-?, ethyl ester methyl 5-ethyl-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate 2-AMINO-6-ETHYLBENZOIC ACID N-Ethylaniline

Preparation Products

Paquinimod Suppliers

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Guangzhou TongYi biochemistry technology Co.,LTD 		+8613073028829 mack@tongyon.com China 2996 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Guangzhou TongYi biochemistry technology Co.,LTD 		58
Alfa Chemistry 		58
LEAP CHEM CO., LTD. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58

Paquinimod Spectrum

Paquinimod(248282-01-1)1HNMR

248282-01-1(Paquinimod)Related Search:

N,N'-Ethylenebis(stearamide) Deionized water (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
Paquinimod ABR?215757 N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide ABR 25757 ABR 25757;ABR-25757;ABR25757;PAQUINIMOD;248282-01-1 ABR25757 ABR-25757 ABR?215757; ABR 215757; ABR215757; PAQUINIMOD. N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide 3-Quinolinecarboxamide, N,5-diethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl- ABR-25757,Inhibitor,ABR25757,inhibit,Paquinimod 248282-01-1