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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate structure

CAS No.: 27143-07-3

Chemical Name:: Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Synonyms: Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;hydrazono);Apixaban-2;Ethyl chloro;RSYY（Avanafil)-38;RSYY（Avanafil)-43

CBNumber:: CB92500866

Molecular Formula:: C11H13ClN2O3

Molecular Weight:: 256.69

MDL Number:: MFCD02852962

MOL File:: 27143-07-3.mol

MSDS File:: SDS

Last updated:2024-08-05 20:55:42

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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Properties

Melting point	94℃
Boiling point	349.0±44.0 °C(Predicted)
Density	1.23
storage temp.	2-8°C
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Solid
pka	11.63±0.10(Predicted)
color	Yellow to Dark Yellow
InChI	InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
InChIKey	ATNPZEGMKLGIFA-UHFFFAOYSA-N
SMILES	C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	Z346018	Ethyl2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate	27143-07-3	50mg	$50	2021-12-16	Buy
Ark Pharm	AK-94053	Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 97%	27143-07-3	10g	$68	2021-12-16	Buy
AK Scientific	J96727	(Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate	27143-07-3	10g	$95	2021-12-16	Buy
Matrix Scientific	058646	Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate >95%	27143-07-3	500mg	$126	2021-12-16	Buy
Matrix Scientific	058646	Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate >95%	27143-07-3	1g	$160	2021-12-16	Buy

Product number	Packaging	Price	Buy
Z346018	50mg	$50	Buy
AK-94053	10g	$68	Buy
J96727	10g	$95	Buy
058646	500mg	$126	Buy
058646	1g	$160	Buy

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties,Uses,Production

Physical properties

Light yellow to dark yellow solid

Uses

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.

Synthesis

Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate synthesis

Synthesis of Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate from p-Anisidine and Ethyl 2-chloroacetoacetate

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Preparation Products And Raw materials

Raw materials

p-Anisidine Ethyl 4-chloroacetoacetate

Preparation Products

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Suppliers

Global( 457)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Million Pharmaceutical Co., Ltd	0531-68659554 +8613031714605	info@millionpharm.com	China	205	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Jinan Jianfeng Chemical Co., Ltd	+8615562555968	info@pharmachemm.com	China	247	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12446	58
Shanghai Joiny Pharmaceutical Co.,LTD	+8613681955282	gyd@joiny-pharma.com	China	253	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	990	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20293	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	973	58

Supplier	Advantage
Jinan Million Pharmaceutical Co., Ltd	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Jinan Jianfeng Chemical Co., Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58

View Lastest Price from Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-09-20	Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3	US $2.00 / kg	1kg	99%	1200KG/M	Jinan Million Pharmaceutical Co., Ltd
2024-09-20	Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 27143-07-3	US $20.00-10.00 / kg	1kg	99%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-09-20	Apixaban intermediate 27143-07-3	US $30.00 / kg	1kg	99%	2000kg	hebei hongtan Biotechnology Co., Ltd

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
27143-07-3
US $2.00 / kg
99%
Jinan Million Pharmaceutical Co., Ltd

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
27143-07-3
US $20.00-10.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

Apixaban intermediate
27143-07-3
US $30.00 / kg
99%
hebei hongtan Biotechnology Co., Ltd

27143-07-3(Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate)Related Search:

Apixaban Impurity 20 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 13 ETHYL (2E)-CHLORO[(4-CHLOROPHENYL)HYDRAZONO]ACETATE

1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 11 Apixaban IMpurity 5 (BMS-591329-01)

3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone

4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl (R)-3-Piperidinamine dihydrochloride

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2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] (Z)- Ethyl chloro[(4-Methoxyphenyl)hydrazono]acetate Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene], ethyl ester ethyl chloro[2-(4-Methoxyphenyl)hydrazinylidene]acetate thyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate Chloro((4-Methoxyphenyl)hydrazone)acetic acid ethyl ester 1. 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]acetic acid ethyl ester 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene] acetic acid, ethyl ester Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester ethyl (2Z)-2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate Apixaban Intermediate 1 Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazono) ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate Apixaban Impurity B (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Apixaban) Apixaban-2 1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl ester ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，Aceticacid,2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester Apixaban intermediates，Ethyl chloro[2-(4- methoxyphenyl)hydrazinylidene]acetate Apixaban ethyl chloroacetate Apixaban Impurity 158 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Apixaban Impurity 18 Ethyl 2-chloro-2-(2 -(4-methoxyphenyl)hydrazono)acetate chloro ester ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazono]acetate Impurity of apixaban382 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl este Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate (Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate Aceticacid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethylester,(8Z)- RSYY（Avanafil)-38 RSYY（Avanafil)-43 Ethyl [(4-methoxyphenyl)hydrazono]chloroacetate Ethyl chloro (Z)-Ethyl-2-C-2-(2-(4-Methoxy Phenyl) Hydrazone acetate Ethyl chloro[(4-methoxyphenyl)hydrazono]acetat Ethyl 2-chloro-2-[2-(4-methyoxyphenyl)hydrazono]acetate Apixaban Impurity 2 27143-07-3 27143-07-0 27143-07-2 27143-07-3