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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

CAS No.
27143-07-3
Chemical Name:
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Synonyms
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;hydrazono);Apixaban-2;Ethyl chloro;RSYY(Avanafil)-38;RSYY(Avanafil)-43
CBNumber:
CB92500866
Molecular Formula:
C11H13ClN2O3
Molecular Weight:
256.69
MDL Number:
MFCD02852962
MOL File:
27143-07-3.mol
MSDS File:
SDS
Last updated:2024-08-05 20:55:42

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Properties

Melting point 94℃
Boiling point 349.0±44.0 °C(Predicted)
Density 1.23
storage temp. 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
form Solid
pka 11.63±0.10(Predicted)
color Yellow to Dark Yellow
InChI InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
InChIKey ATNPZEGMKLGIFA-UHFFFAOYSA-N
SMILES C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC Z346018 Ethyl2-Chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 27143-07-3 50mg $50 2021-12-16 Buy
Ark Pharm AK-94053 Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 97% 27143-07-3 10g $68 2021-12-16 Buy
AK Scientific J96727 (Z)-Ethyl2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate 27143-07-3 10g $95 2021-12-16 Buy
Matrix Scientific 058646 Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate >95% 27143-07-3 500mg $126 2021-12-16 Buy
Matrix Scientific 058646 Ethyl-2-chloro-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]acetate >95% 27143-07-3 1g $160 2021-12-16 Buy
Product number Packaging Price Buy
Z346018 50mg $50 Buy
AK-94053 10g $68 Buy
J96727 10g $95 Buy
058646 500mg $126 Buy
058646 1g $160 Buy

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties,Uses,Production

Physical properties

Light yellow to dark yellow solid

Uses

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.

Synthesis

Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.

104-94-9
609-15-4
27143-07-3
Synthesis of Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate from p-Anisidine and Ethyl 2-chloroacetoacetate

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 457)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Million Pharmaceutical Co., Ltd
0531-68659554 +8613031714605 info@millionpharm.com China 205 58
Shanghai Rochi Pharmaceutical Co.,Ltd.
21-38751876 +8615000076078 info@rochipharma.com China 431 58
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Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578 sales@hbmojin.com China 12446 58
Shanghai Joiny Pharmaceutical Co.,LTD
+8613681955282 gyd@joiny-pharma.com China 253 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 990 58
Anhui Ruihan Technology Co., Ltd
+8617756083858 daisy@anhuiruihan.com China 994 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652 info@fdachem.com China 20293 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 973 58

View Lastest Price from Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester pictures 2024-09-20 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
27143-07-3
US $2.00 / kg 1kg 99% 1200KG/M Jinan Million Pharmaceutical Co., Ltd
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester pictures 2024-09-20 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
27143-07-3
US $20.00-10.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
Apixaban intermediate pictures 2024-09-20 Apixaban intermediate
27143-07-3
US $30.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] (Z)- Ethyl chloro[(4-Methoxyphenyl)hydrazono]acetate Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene], ethyl ester ethyl chloro[2-(4-Methoxyphenyl)hydrazinylidene]acetate thyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate Chloro((4-Methoxyphenyl)hydrazone)acetic acid ethyl ester 1. 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]acetic acid ethyl ester 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene] acetic acid, ethyl ester Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester ethyl (2Z)-2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate Apixaban Intermediate 1 Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazono) ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate Apixaban Impurity B (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Apixaban) Apixaban-2 1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl ester ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate,Aceticacid,2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester Apixaban intermediates,Ethyl chloro[2-(4- methoxyphenyl)hydrazinylidene]acetate Apixaban ethyl chloroacetate Apixaban Impurity 158 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Apixaban Impurity 18 Ethyl 2-chloro-2-(2 -(4-methoxyphenyl)hydrazono)acetate chloro ester ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazono]acetate Impurity of apixaban382 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl este Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate (Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate Aceticacid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethylester,(8Z)- RSYY(Avanafil)-38 RSYY(Avanafil)-43 Ethyl [(4-methoxyphenyl)hydrazono]chloroacetate Ethyl chloro (Z)-Ethyl-2-C-2-(2-(4-Methoxy Phenyl) Hydrazone acetate Ethyl chloro[(4-methoxyphenyl)hydrazono]acetat Ethyl 2-chloro-2-[2-(4-methyoxyphenyl)hydrazono]acetate Apixaban Impurity 2 27143-07-3 27143-07-0 27143-07-2 27143-07-3