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KU57788(NU7441)

KU57788(NU7441) Structure
KU57788(NU7441) structure
CAS No.
503468-95-9
Chemical Name:
KU57788(NU7441)
Synonyms
CS-181;NU 7441;KU 57788;KU57788(NU7441);NU-7441 (KU-57788);NU 7441 - KU 47788;KU57788(NU7441) USP/EP/BP;NU7441;KU57788;NU 7441 (KU 57788);NU7441 (KU-57788);KU 57788; NU-7441;NU 7441 (This product is only available in Japan.)
CBNumber:
CB92500947
Molecular Formula:
C25H19NO3S
Molecular Weight:
413.49
MDL Number:
MFCD11983069
MOL File:
503468-95-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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KU57788(NU7441) Properties

Melting point 220-221 °C
Boiling point 646.9±55.0 °C(Predicted)
Density 1.376±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility Soluble in DMSO (up to 10 mg/ml with warming).
form solid
pka 0.51±0.20(Predicted)
color Off-white to beige
Stability Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII XF6ZJD5WGU

KU57788(NU7441) price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 14881 NU 7441 ≥98% 503468-95-9 5mg $43 2024-03-01 Buy
Cayman Chemical 14881 NU 7441 ≥98% 503468-95-9 1mg $26 2023-06-20 Buy
Cayman Chemical 14881 NU 7441 ≥98% 503468-95-9 10mg $77 2024-03-01 Buy
Cayman Chemical 14881 NU 7441 ≥98% 503468-95-9 25mg $140 2024-03-01 Buy
Tocris 3712 NU7441 ≥99%(HPLC) 503468-95-9 10 $227 2021-12-16 Buy
Product number Packaging Price Buy
14881 5mg $43 Buy
14881 1mg $26 Buy
14881 10mg $77 Buy
14881 25mg $140 Buy
3712 10 $227 Buy

KU57788(NU7441) Chemical Properties,Uses,Production

Description

DNA-dependent protein kinase (DNA-PK) catalyzes nonhomologous end-joining, which is required to repair lethal DNA double-strand breaks. Because cells that are defective in DNA double-strand break repair are highly sensitive to ionizing radiation and topoisomerase II poisons, modulating DNA-PK is one strategy to defer cancer cell resistance to radiation or chemotherapeutic treatments. NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM. It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively. NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.

Uses

A potent novel DNA-dependent protein kinase inhibitor models of human cancer. Antitumor agent.

Uses

A potent and selective DNA-PK inhibitor with an IC50 of 14 nM.

Definition

ChEBI: 8-(4-dibenzothiophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of dibenzothiophenes.

storage

Store at +4°C

References

1) Leahy?et al.?(2004),?Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries; Bioorg. Med. Chem. Lett.,?14?6083 2) Hardcastle?et al.?(2005),?Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach: J. Med. Chem.,?48?7829 3) Zhao?et al.?(2006),?Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441: Cancer Res.?66?5354 4) Ciszewski?et al.?(2014),?DNA-PK inhibition by NU7441 sensitizes breast cancer cells to ionizing radiation and doxorubicin: Breast Cancer Res. Treat.,?143?83 5) Yang?et al.?(2016),?NU7441 Enhances the Radiosensitivity of Liver Cancer Cells: Cell Physiol. Biochem.,?38?1897 6) Geng?et al.?(2019),?DNA-PKcs inhibitor increases the sensitivity of gastric cancer cells to radiotherapy: Oncol. Rep.,?42?561

KU57788(NU7441) Preparation Products And Raw materials

Raw materials

Preparation Products

KU57788(NU7441) Suppliers

Global( 127)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 967 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10297 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Hubei xin bonus chemical co. LTD 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
Fuxin Pharmaceutical 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from KU57788(NU7441) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KU57788(NU7441) pictures 2019-07-06 KU57788(NU7441)
503468-95-9
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co

KU57788(NU7441) Spectrum

KU57788(NU7441)(503468-95-9)1HNMR

503468-95-9(KU57788(NU7441))Related Search:

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KU57788(NU7441) NU 7441 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one 8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one NU7441 (KU-57788);KU 57788; NU-7441 KU 57788 NU-7441 (KU-57788) 4H-1-Benzopyran-4-one, 8-(4-dibenzothienyl)-2-(4-morpholinyl)- 8-(4-Dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one NU-7441 NU 7441 (This product is only available in Japan.) CS-181 NU 7441 - KU 47788 NU7441;KU57788;NU 7441 (KU 57788) 8-(Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one KU57788(NU7441) USP/EP/BP 503468-95-9 Inhibitors Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds