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Thiazovivin

Description In vitro
Thiazovivin
Thiazovivin structure
CAS No.
1226056-71-8
Chemical Name:
Thiazovivin
Synonyms
Thiazovivin;Thiazovivin (Tzv);Thiazovivin, >=98%;N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide;N-Benzyl-2-(4-pyrimidinylamino)-1,3-thiazole-4-carboxamide;N-(Phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide;Thiazovivin N-(Phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide;N-(Phenylmethyl)-2-(4-pyrimidinylamino)-4-thiazolecarboxamide Thiazovivin
CBNumber:
CB92512070
Molecular Formula:
C15H13N5OS
Formula Weight:
311.36162
MOL File:
1226056-71-8.mol

Thiazovivin Properties

Density 
1.379
storage temp. 
Store at -20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
, white to beige to brown
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3

Thiazovivin price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1045 Thiazovivin ≥98% (HPLC) 1226056-71-8 5mg $115 2018-11-20 Buy
Sigma-Aldrich SML1045 Thiazovivin ≥98% (HPLC) 1226056-71-8 25mg $370 2018-11-20 Buy
Cayman Chemical 14245 Thiazovivin ≥98% 1226056-71-8 1mg $35 2018-11-13 Buy
Cayman Chemical 14245 Thiazovivin ≥98% 1226056-71-8 5mg $88 2018-11-13 Buy
Cayman Chemical 14245 Thiazovivin ≥98% 1226056-71-8 10mg $140 2018-11-13 Buy

Thiazovivin Chemical Properties,Uses,Production

Description

Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation.

In vitro

Although displaying little impact on cell proliferation, Thiazovivin treatment significantly enhances the survival of human embryonic stem cells (hESCs) after enzymatic dissociation more than 30-fold, while homogenously maintaining pluripotency with the characteristic colony morphology, expression of typical pluripotency markers such as alkaline phosphatase (ALP), and normal karyotype. Dissociated hESCs treated with Thiazovivin display dramatically increased adhesion to matrigel-or laminin-coated plates but not to gelatin-coated plates within a few hours. Thiazovivin treatment increases cell-ECM adhesion-mediated β1 integrin activity, which synergizes with growth factors to promote cell survival. In addition to activating integrin, Thiazovivin but not Tyrintegin (Ptn) protects hESCs from death in the absence of ECM in suspension through E-cadherin-mediated cell-cell interaction. Thiazovivin treatment potently inhibits endocytosis of E-cadherin, consequently stabilizing E-cadherin on the cell surface and leading to reestablishment of cell-cell interaction, which is essential for hESC survival in ECM-free conditions. Thiazovivin but not Tyrintegin (Ptn) at 2 μM inhibits Rho-associated kinase (ROCK) activity and protects hESCs at a similar level as the widely used selective ROCK inhibitor Y-27632 at 10 μM, suggesting that Rho-ROCK signaling regulates cell-ECM and cell-cell adhesion. [1] Thiazovivin at 1 μM increases the reprogramming efficiency of CB mononuclear cells to induced pluripotent stem cells (iPSCs) by more than 10 times.

Uses

A compound that improves the survival of human embryonic stem cells (hESCs) upon trypsinization. In combination with ALK5 (TGFβ receptor) inhibitor SB-431542 and MEK inhibitor PD-0325901 (P217450), Thiazovivin promotes the transformation of fibroblasts into stem cells with a 200-fold efficiency over the classic method

Thiazovivin Preparation Products And Raw materials

Raw materials

Preparation Products


Thiazovivin Suppliers

Global( 86)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35440 58
D&C Chemicals +86-21-58447131
+86-21-61642470 1724405207@qq.com China 473 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15881 69
ChemFuture PharmaTech (Jiangsu) Ltd 86 510 85386188 ;86 510 85386988-8021
86 510 85386988-8017 Sales@chemfuture.com China 804 65

View Lastest Price from Thiazovivin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-09 Thiazovivin
1226056-71-8
US $2.00 / KG 1KG 99% customise career henan chemical co

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