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WYE-354

WYE-354 structure

CAS No.: 1062169-56-5

Chemical Name:: WYE-354

Synonyms: CS-441;WYE-354;Wye354 Wye-354;WYE-354 USP/EP/BP;WYE-354 (Degrasyn);WYE-354;WYE 354; WYE354;mTOR Kinase Inhibitor II WYE-354 WYE354;Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip;methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate;Methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate

CBNumber:: CB92512520

Molecular Formula:: C24H29N7O5

Molecular Weight:: 495.53

MDL Number:: MFCD18074514

MOL File:: 1062169-56-5.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:22

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WYE-354 Properties

Density	1.46
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	≥49.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form	solid
pka	13.42±0.70(Predicted)

WYE-354 price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	475986	mTOR Kinase Inhibitor II, WYE-354 - CAS 1062169-56-5 - Calbiochem	1062169-56-5	5MG	$318	2024-03-01	Buy
Cayman Chemical	13604	WYE-354 ≥98%	1062169-56-5	5mg	$93	2024-03-01	Buy
Cayman Chemical	13604	WYE-354 ≥98%	1062169-56-5	10mg	$176	2024-03-01	Buy
Cayman Chemical	13604	WYE-354 ≥98%	1062169-56-5	25mg	$412	2024-03-01	Buy
Cayman Chemical	13604	WYE-354 ≥98%	1062169-56-5	50mg	$728	2024-03-01	Buy

Product number	Packaging	Price	Buy
475986	5MG	$318	Buy
13604	5mg	$93	Buy
13604	10mg	$176	Buy
13604	25mg	$412	Buy
13604	50mg	$728	Buy

WYE-354 Chemical Properties,Uses,Production

Description

WYE-354 is a potent cell-permeable inhibitor of mTOR (IC₅₀ = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of phosphatidylinositol 3-kinase α (IC₅₀ = 1,026 nM) and other kinases. WYE-354 induces G₁ cell cycle arrest in both rapamycin-sensitive and rapamycin-resistant cancer cell lines, inhibits mTORC1 and mTORC2 in tumor-bearing mice, and reduces tumor growth in nude mice with PTEN-null tumors.

Uses

A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and Akt as the respective substrate (IC50 <200 nM; [ATP] = 100 μM) and effectively blocks cellular phosphorylation of S6K on T389 and Akt on S473 both in cultures and in a murine xenograft model, resulting in a significant suppression of PC3MM2-derived tumor growth (by 86% on day 7; 50 mg/kg, i.p twice per day) in vivo.

Definition

ChEBI: 4-[6-[4-(methoxycarbonylamino)phenyl]-4-(4-morpholinyl)-1-pyrazolo[3,4-d]pyrimidinyl]-1-piperidinecarboxylic acid methyl ester is a carbamate ester.

target

mTOR

References

[1] qingsong liu, carson thoreen, jinhua wang, david sabatini, nathanael s. gray. mtor mediated anti-cancer drug discovery. drug discovery today. 2009. 6(2): 47-55.
[2] shi-yong sun. mtor kinase inhibitors as potential cancer therapeutic drugs. cancer letters. 28 october 2013. 340(1): 1-8.

WYE-354 Preparation Products And Raw materials

Raw materials

Preparation Products

WYE-354 Suppliers

Global( 93)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from WYE-354 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	WYE-354 1062169-56-5	US $2.00 / kg	1kg	99%	ask	Career Henan Chemical Co

WYE-354
1062169-56-5
US $2.00 / kg
99%
Career Henan Chemical Co

WYE-354 Spectrum

WYE-354(1062169-56-5)¹HNMR

1062169-56-5(WYE-354)Related Search:

WYE 354-d3 N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N'-methylurea WYE-687 Selumetinib U0126-EtOH

MK-2206 2HCl 1,9-Pyrazoloanthrone KU-0063794 BEZ235 (NVP-BEZ235, Dactolisib)

1of2

WYE-354 4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid methyl ester methyl 4-[6-[4-(methoxycarbonylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate WYE-354 (Degrasyn) WYE-354;WYE 354; WYE354 Methyl 4-(6-(4-(methoxycarbonylamino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)pip CS-441 1-Piperidinecarboxylic acid, 4-[6-[4-[(methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-, methyl ester WYE-354 USP/EP/BP Methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate mTOR Kinase Inhibitor II WYE-354 WYE354 Wye354 Wye-354 1062169-56-5 C24H29N7O5 Amines Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators PI3K/Akt/mTOR Inhibitors Akt mTOR PI3K