ChemicalBook >> CAS DataBase List >>(R)-(+)-THALIDOMIDE
(R)-(+)-THALIDOMIDE
- CAS No.
- 2614-06-4
- Chemical Name:
- (R)-(+)-THALIDOMIDE
- Synonyms
- NSC 91729;(+)-Thalidomide;(R)-(+)-THALIDOMIDE;Thalidomide (R)-Isomer;6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid;N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide;(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide;2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione;6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2;(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
- CBNumber:
- CB9251689
- Molecular Formula:
- C13H10N2O4
- Molecular Weight:
- 258.23
- MDL Number:
- MFCD00210220
- MOL File:
- 2614-06-4.mol
- MSDS File:
- SDS
Last updated:2023-05-09 09:30:57
| Melting point | 269-271°C |
|---|---|
| Boiling point | 401.48°C (rough estimate) |
| Density | 1.2944 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO: soluble |
| form | solid |
| pka | 10.70±0.40(Predicted) |
| color | white |
| FDA UNII | QN61H68KLK |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H360 |
| Precautionary statements | P201-P301+P312+P330-P308+P313 |
| Hazard Codes | T |
| Risk Statements | 61-22 |
| Safety Statements | 53-36/37/39-45 |
| WGK Germany | 3 |
| RTECS | TI4925000 |
(R)-(+)-THALIDOMIDE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T151 | (+)-Thalidomide ≥98%(HPLC),powder | 2614-06-4 | 10mg | $128 | 2024-03-01 | Buy |
| Sigma-Aldrich | T151 | (+)-Thalidomide ≥98%(HPLC),powder | 2614-06-4 | 100mg | $826 | 2024-03-01 | Buy |
| TRC | T338855 | (R)-(+)-Thalidomide | 2614-06-4 | 50mg | $495 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000090 | (R)-(+)-THALIDOMIDE 95.00% | 2614-06-4 | 5MG | $738.1 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 13778 | (R)-(+)-Thalidomide | 2614-06-4 | 10mg | $490 | 2021-12-16 | Buy |
(R)-(+)-THALIDOMIDE Chemical Properties,Uses,Production
Chemical Properties
Needles
Uses
Thalidomide has been used to study its teratogenic effects in chicken embryos and human embryonic cells. This study reported that thalidomide causes limb defects by stabilizing PTEN, inhibiting the expression of Akt and activating caspase-dependent apoptosis. Thalidomide has also been used for studying glutathione mediated teratogenic resistance in mouse embryos.
Uses
Optically active isomer of Thalidomide, which inhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative.
Definition
ChEBI: A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has R-configuration at the chiral centre.
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α). (R)-Thalidomide is called "safe enantiomer", but it can be converted in the body to (S)-isomer.
(R)-(+)-THALIDOMIDE Preparation Products And Raw materials
Global( 41)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
2614-06-4((R)-(+)-THALIDOMIDE)Related Search:
(-)-THALIDOMIDE >98% INHIBITOR OF ANGIOG EN,(S)-(-)-THALIDOMIDE
(+-)-THALIDOMIDE >98% IMMUNOSUPPRESSIVE, SE,(+/-)-THALIDOMIDE,THALIDOMIDE,Thalidomide (soluble form)
(R)-3-AMINOPIPERIDIN-2-ONE
3-amino-2-Piperidinone
(R)-(+)-THALIDOMIDE
(R)-3-Aminopiperidine
3-AMINOPIPERIDINE
Phthalimidine, 2-(2,6-dioxopiperiden-3-yl).
N-(piperidin-3-yl)benzamide
3-ACETAMIDOPIPERIDINE
1of4
(R)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3-(2H)-DIONE
R-(+)-2-(2,6-DIOXO-3-PIPERIDINYL)-1H-ISOINDOLE-1,3(2H)-DIONE
(R)-(+)-THALIDOMIDE
6-dioxo-3-piperidinyl)-3(2h)-dion(r)-1h-isoindole-2-(2
6-dioxo-3-piperidyl)-n-(d-(+)-phthalimid
(+)-2-[(R)-2,6-Dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione
(+)-N-[(R)-2,6-Dioxo-3-piperidinyl]phthalimide
(3R)-3-(1,3-Dioxo-2H-isoindole-2-yl)piperidine-2,6-dione
N-[(R)-2,6-Dioxopiperidine-3-yl]phthalimide
NSC 91729
2-[(3R)-2,6-dioxopiperidin-3-yl]isoindole-1,3-dione
Thalidomide (R)-Isomer
1H-Isoindole-1,3(2H)-dione, 2-[(3R)-2,6-dioxo-3-piperidinyl]-
(+)-Thalidomide
2614-06-4
6/4/2614
2614-6-4
Angiogenesis Regulators
BioChemical
Cell Signaling and Neuroscience
Cell Biology
Extracellular Matrix
Cytoskeleton and Extracellular Matrix
Chiral Reagents
Intermediates & Fine Chemicals
Pharmaceuticals