AZ-23
- CAS No.
- 915720-21-7
- Chemical Name:
- AZ-23
- Synonyms
- AZ-23;AZ23; AZ-23;Tropomyosin related kinase receptor,Inhibitor,inhibit,AZ-23,Trk Receptor;5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;(S)-5-chloro-N2-(1-(5-fluoropyridin-2-yl)ethyl)-N4-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 5-chloro-N2-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-N4-[5-(1-methylethoxy)-1H-pyrazol-3-yl]-
- CBNumber:
- CB92518274
- Molecular Formula:
- C17H19ClFN7O
- Molecular Weight:
- 391.8304632
- MDL Number:
- MFCD17215208
- MOL File:
- 915720-21-7.mol
- MSDS File:
- SDS
| Boiling point | 596.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.411 |
| storage temp. | Store at -20°C |
| solubility | DMSO:125.0(Max Conc. mg/mL);319.02(Max Conc. mM) |
| pka | 12.37±0.10(Predicted) |
| FDA UNII | 009OMI967N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
AZ-23 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C424360 | 5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N''-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine | 915720-21-7 | 25mg | $1470 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA102951 | AZ 23 | 915720-21-7 | 10mg | $185 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001065 | AZ-23 95.00% | 915720-21-7 | 2MG | $234 | 2021-12-16 | Buy |
| AK Scientific | 2363CW | AZ-23 | 915720-21-7 | 10mg | $299 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001065 | AZ-23 95.00% | 915720-21-7 | 5MG | $501.68 | 2021-12-16 | Buy |
AZ-23 Chemical Properties,Uses,Production
Uses
5-Chloro-N-[(1S)-1-(5-fluoropyridin-2-yl)ethyl]-N'-(5-isopropoxy-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZ-23) is a potent and selective tyrosine kinase inhibitor which may be used in the therapeutic treatment of cancers.
Biological Activity
AZ-23 is an ATP-competitive, orally active Trk kinase A/B/C inhibitor with IC50 values of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3) , 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck).
in vitro
AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC 50 of 2 nM). AZ-23 Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines.
in vivo
AZ-23 shows in vivo TrkA kinase inhibition and efficacy in mice following oral administration in a TrkA-driven allograft model and significant tumor growth inhibition in a Trk-expressing xenograft model of neuroblastoma .
target
| TrkA 2 nM (IC 50 ) | TrkB 8 nM (IC 50 ) |
AZ-23 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1494 | 55 | |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9901 | 58 | |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |