ChemicalBook >> CAS DataBase List >>3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide structure

CAS No.: 1164470-53-4

Chemical Name:: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

Synonyms: 003;Sal 003;CS-1897;(2E)-3-Phenyl-N-(2;SAL-003;SAL 003;SAL003;eIF-2α Inhibitor II, Sal003;Sal-003,Sal 003,Apoptosis,Inhibitor,Sal003,inhibit,Phosphatase;2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide;(E)-N-(2,2,2-Trichloro-1-(3-(4-chlorophenyl)thioureido)ethyl)cinnamamide;3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

CBNumber:: CB92518799

Molecular Formula:: C18H15Cl4N3OS

Molecular Weight:: 463.21

MDL Number:: MFCD00361095

MOL File:: 1164470-53-4.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Properties

storage temp.	2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
color	white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS09
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273-P501
Hazard Codes	N
Risk Statements	50/53
Safety Statements	60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S4451	Sal003 ≥98% (HPLC)	1164470-53-4	5mg	$149	2024-03-01	Buy
Sigma-Aldrich	S4451	Sal003 ≥98% (HPLC)	1164470-53-4	25mg	$595	2024-03-01	Buy
Cayman Chemical	23414	Sal-003 ≥98%	1164470-53-4	5mg	$97	2024-03-01	Buy
Cayman Chemical	23414	Sal-003 ≥98%	1164470-53-4	10mg	$155	2024-03-01	Buy
Tocris	3657	Sal003 ≥99%(HPLC)	1164470-53-4	10	$182	2021-12-16	Buy

Product number	Packaging	Price	Buy
S4451	5mg	$149	Buy
S4451	25mg	$595	Buy
23414	5mg	$97	Buy
23414	10mg	$155	Buy
3657	10	$182	Buy

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Chemical Properties,Uses,Production

Uses

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.

Biological Activity

eukaryotic initiation factor 2 α-subunit (eif2α) plays a critical role in the regulation of protein synthesis. moreover, it also plays an important role in synaptic plasticity and long-term memory consolidation. sal003 is a selective inhibitor of eif2α dephosphorylation.

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.

in vitro

sal003 specifically prevents dephosphorylation of eif2α by blocking eif2α phosphatases. in sal003-treated cells polysomes dissociated and consistent with this β-actin mrna shifted to lighter fractions, reflecting the inhibition of general translation [1].

in vivo

intra-basolateral amygdala (bla) infusions of sal003 immediately after memory retrieval disrupted the reconsolidation of morphine- or cocaine-induced cpp, leading to a long-lasting suppression of drug-paired stimulus-induced craving. moreover, inhibition of eif2α dephosphorylation in the bla immediately after light/tone stimulus retrieval decreased subsequent cue-induced heroin-seeking behavior in the self-administration procedure. these results demonstrate that eif2α dephosphorylation in the bla mediates the memory reconsolidation of drug-paired stimuli [1].

storage

Store at -20°C

References

[1] jian m, luo yx, xue yx, han y, shi hs, liu jf, yan w, wu p, meng sq, deng jh, shen hw, shi j, lu l. eif2α dephosphorylation in basolateral amygdala mediates reconsolidation of drug memory. j neurosci. 2014;34(30):10010-21.

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Suppliers

Global( 62)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4647	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Dalian Meilun Biotech Co., Ltd.	58

View Lastest Price from 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-20	1164470-53-4 1164470-53-4	US $1.00 / KG	1KG	99%	100kgs	Career Henan Chemical Co

1164470-53-4
1164470-53-4
US $1.00 / KG
99%
Career Henan Chemical Co

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Spectrum

3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide(1164470-53-4)¹HNMR

1164470-53-4(3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide)Related Search:

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1of3

eIF-2α Inhibitor II, Sal003 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide Sal 003 (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide SAL003 SAL-003;SAL 003;SAL003 CS-1897 (2E)-3-Phenyl-N-(2 2-trichloro-1-{[(4-chlorophenyl)carbamothioyl]amino}ethyl)acrylamide SAL003;(2E)-3-PHENYL-N-(2;2;2-TRICHLORO-1-{[(4-CHLOROPHENYL)CARBAMOTHIOYL]AMINO}ETHYL)ACRYLAMIDE 003 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-, (2E)- (E)-N-(2,2,2-Trichloro-1-(3-(4-chlorophenyl)thioureido)ethyl)cinnamamide Sal-003,Sal 003,Apoptosis,Inhibitor,Sal003,inhibit,Phosphatase 1164470-53-4 Inhibitors