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ChemicalBook >> CAS DataBase List >>α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile Structure
α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile structure
CAS No.
853910-02-8
Chemical Name:
α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile
Synonyms
CS-437;BAG 956;NVP-BAG 956;NVP-BAG956, >=98%;BAG956(NVP-BAG956);NVP-BAG 956 BAG 956;NVP-BAG956;BAG 956;NVP-BAG 956;NVP BAG956,NVPBAG956,NVP-BAG-956;PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem;2-Methyl-2-[4-[2-methyl-8-[(pyridin-3-yl)ethynyl]imidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile
CBNumber:
CB92518951
Molecular Formula:
C28H21N5
Molecular Weight:
427.51
MDL Number:
MFCD16618394
MOL File:
853910-02-8.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile Properties

Melting point >224oC (dec.)
Boiling point 694.8±65.0 °C(Predicted)
Density 1.17
storage temp. Store at RT
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form Orange powder
pka 4.99±0.30(Predicted)
color White
FDA UNII 4UFC2K6E50

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 528121 PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem 853910-02-8 5mg $251 2023-01-07 Buy
Cayman Chemical 24195 NVP-BAG956 ≥98% 853910-02-8 1mg $37 2024-03-01 Buy
Cayman Chemical 24195 NVP-BAG956 ≥98% 853910-02-8 5mg $151 2024-03-01 Buy
Cayman Chemical 24195 NVP-BAG956 ≥98% 853910-02-8 10mg $231 2024-03-01 Buy
Tocris 3606 BAG956 ≥99%(HPLC) 853910-02-8 10 $263 2021-12-16 Buy
Product number Packaging Price Buy
528121 5mg $251 Buy
24195 1mg $37 Buy
24195 5mg $151 Buy
24195 10mg $231 Buy
3606 10 $263 Buy

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile Chemical Properties,Uses,Production

Uses

NVP-BAG956 acts as a rapamycin inhibitor used in the treatment of various melanomas through cell-induced apoptosis. Also used in antileukemic therapies as a dual PI3K/PDK-1 inhibitor.

General Description

A cell-permeable imidazoquinoline compound that acts as a potent, reversible, and ATP-competitive PI 3-K/PDK1 dual kinase inhibitor (IC50 = 56, 446, 35, 117, and 245 nM against p110α, p110β, p110δ, p110γ, and PDK1, respectively), displaying much reduced potency against VEGFR1 (IC50 = 2.56 μM) and little or no activity toward a panel of 15 other kinases (IC50 >10 μM). Shown to effectively inhibit the constitutive phosphorylation of PKB (T308 & S473; IC50 ≤45 nM) as well as PKB downstream effectors GSK3β (S9), FKHRL1 (T32), and p70S6K (T389) in human glioma U87MG and adeonocarcinoma PC3M cultures with PTEN deletion in vitro and retard PC3M-derived tumor growth in mice (by 50%; 75 mg/kg; twice per day p.o.) in vivo. Also reported to exhibit antiproliferative activities against BCRF-ABL- and mutant FLT3-expressing cells either alone or in combination with other PI3K/AKT, mTOR, and tyrosine kinase inhibitors, LY294002 (Cat. Nos. 440202 & 440204), Rapamycin (Cat. No. 553210), and PKC412 (Cat. No. 539648).

storage

Store at -20°C

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile Suppliers

Global( 64)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6011 61
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Coresyn Pharmatech Co., Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chembest Research Laboratories Limited 61

View Lastest Price from α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NVP-BAG956 pictures 2020-01-13 NVP-BAG956
853910-02-8
 US $1.00 / g 1g 99% 1ton Career Henan Chemical Co
  • NVP-BAG956 pictures
  • NVP-BAG956
    853910-02-8
  • US $1.00 / g
  • 99%
  • Career Henan Chemical Co
BAG 956 α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile 2-Methyl-2-[4-[2-methyl-8-[(pyridin-3-yl)ethynyl]imidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile 2-Methyl-2-[4-(2-methyl-8-pyridin-3-ylethynyl-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile,NVP-BAG NVP-BAG 956 BAG 956 NVP-BAG956, >=98% BAG956(NVP-BAG956) NVP-BAG956;BAG 956;NVP-BAG 956 NVP-BAG 956 2-Methyl-2-(4-(2-Methyl-8-(pyridin-3-ylethynyl)-1H-iMidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile CS-437 PI 3-K/PDK-1 Inhibitor, NVP-BAG956 - CAS 853910-02-8 - Calbiochem 2-methyl-2-[4-[2-methyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile Benzeneacetonitrile, α,α-dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]- NVP BAG956,NVPBAG956,NVP-BAG-956 α,α,-Dimethyl-4-[2-methyl-8-[2-(3-pyridinyl)ethynyl]-1H-imidazo[4,5-c]quinolin-1-yl]-benzeneacetonitrile 853910-02-8 Akt mTOR PI3K