Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CP466722

CP466722

CP466722 Structure
CP466722 structure
CAS No.
1080622-86-1
Chemical Name:
CP466722
Synonyms
CS-73;CP466722;CP-466722, >98%;CP-466722;CP466722;CP466722 USP/EP/BP;CP466722 >=98% (HPLC);CP466722;CP 466722;CP-466722;2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine;2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine
CBNumber:
CB92535567
Molecular Formula:
C17H15N7O2
Molecular Weight:
349.35
MDL Number:
MFCD17392566
MOL File:
1080622-86-1.mol
MSDS File:
SDS
Last updated:2023-09-04 15:50:00
Request For Quotation

CP466722 Properties

Boiling point 642.3±65.0 °C(Predicted)
Density 1.48
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility DMSO: soluble0.5mg/mL, clear (warmed)
pka 0.00±0.19(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
NFPA 704
0
2 0

CP466722 price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1115 CP466722 ≥98% (HPLC) 1080622-86-1 5mg $212 2022-05-15 Buy
Sigma-Aldrich SML1115 CP466722 ≥98% (HPLC) 1080622-86-1 25mg $724 2022-05-15 Buy
Cayman Chemical 25417 CP 466,722 ≥98% 1080622-86-1 1mg $41 2024-03-01 Buy
Cayman Chemical 25417 CP 466,722 ≥98% 1080622-86-1 5mg $183 2024-03-01 Buy
Cayman Chemical 25417 CP 466,722 ≥98% 1080622-86-1 10mg $322 2024-03-01 Buy
Product number Packaging Price Buy
SML1115 5mg $212 Buy
SML1115 25mg $724 Buy
25417 1mg $41 Buy
25417 5mg $183 Buy
25417 10mg $322 Buy

CP466722 Chemical Properties,Uses,Production

Description

CP 466,722 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase that inhibits ionizing radiation-induced ATM autophosphorylation and phosphorylation of the ATM targets SMC1, Chk2, and p53 in HeLa cells when used at a concentration of 10 μM. It is selective for ATM over PI3K and PIKK in HFF(hTERT) and A-T(hTERT) fibroblasts, respectively. CP 466,722 decreases cell survival in response to ionizing radiation in HeLa cells. It is also cytotoxic to MCF-7 and SKBr-3 breast cancer cells (IC50s = 16.92 and 12.78 μM, respectively).

Uses

CP466722 is a competetive, reversible inhbitor of Ataxia telangiectasia (A-T) mutated (ATM) kinase

Definition

ChEBI: 2-(6,7-dimethoxy-4-quinazolinyl)-5-(2-pyridinyl)-1,2,4-triazol-3-amine is a member of quinazolines.

target

ATM

References

[1]. guo, k., et al., development of a cell-based, high-throughput screening assay for atm kinase inhibitors. j biomol screen, 2014. 19(4): p. 538-46.
[2]. nadkarni, a., et al., atm inhibitor ku-55933 increases the tmz responsiveness of only inherently tmz sensitive gbm cells. j neurooncol, 2012. 110(3): p. 349-57.
[3]. rainey, m.d., et al., transient inhibition of atm kinase is sufficient to enhance cellular sensitivity to ionizing radiation. cancer res, 2008. 68(18): p. 7466-74.

CP466722 Preparation Products And Raw materials

Raw materials

Preparation Products

CP466722 Suppliers

Global( 99)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49390 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29220 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58

View Lastest Price from CP466722 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine pictures 2019-09-06 CP466722;1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine
1080622-86-1
 US $1.00 / ASSAYS 1ASSAYS 95%~99% per week:100kg Career Henan Chemical Co

CP466722 Spectrum

CP466722(1080622-86-1)1HNMR

1080622-86-1(CP466722)Related Search:

Y27632 (hydrochloride) Gefitinib ABT 737 Sunitinib Malate Docetaxel
Olaparib

1of2

CP466722 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine 2-(6,7-dimethoxyquinazolin-4-yl)-5-(pyridin-2-yl)-2H-1,2,4-triazol-3-amine 1-(6,7-Dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)-1H-1,2,4-triazol-5-amine CP 466722 2-(6,7-dimethoxyquinazolin-4-yl)-5-pyridin-2-yl-1,2,4-triazol-3-amine CP-466722;CP466722 1-(6,7-Dimethoxyquinazolin-4-yl)-3-(pyridin-2-yl)-1H-1,2,4-triazol-5-amine CP466722;CP 466722;CP-466722 CS-73 CP-466722, >98% 1H-1,2,4-Triazol-5-amine, 1-(6,7-dimethoxy-4-quinazolinyl)-3-(2-pyridinyl)- CP466722 >=98% (HPLC) CP466722 USP/EP/BP 1080622-86-1 C17H15N7O2 Inhibitors