A 839977
- CAS No.
- 870061-27-1
- Chemical Name:
- A 839977
- Synonyms
- A 839977;ACHEMBLOCK F-4551;1-(2,3-dichlorophenyl)-n-[2-(2-pyridinyloxy)benzyl]-1h-tetrazol-5 -amine;1-(2,3-dichlorophenyl)-N-[(2-pyridin-2-yloxyphenyl)methyl]tetrazol-5-amine;1-(2,3-Dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]Methyl]-1H-tetrazol-5-aMine;1H-Tetrazol-5-amine, 1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-;1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine;1-(2,3-DICHLOROPHENYL)-N-{[2-(PYRIDIN-2-YLOXY)PHENYL]METHYL}-1H-1,2,3,4-TETRAZOL-5-AMINE;A839977 1-(2,3-dichlorophenyl)-N-{[2-(pyridin-2-yloxy)phenyl]methyl}-1H-1,2,3,4-tetrazol-5-amine
- CBNumber:
- CB92538270
- Molecular Formula:
- C19H14Cl2N6O
- Molecular Weight:
- 413.26
- MDL Number:
- MFCD19690959
- MOL File:
- 870061-27-1.mol
A 839977 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 4232 | A839977 ≥98%(HPLC) | 870061-27-1 | 10 | $217 | 2021-12-16 | Buy |
| Tocris | 4232 | A839977 ≥98%(HPLC) | 870061-27-1 | 50 | $851 | 2021-12-16 | Buy |
| TRC | A965365 | A839977 | 870061-27-1 | 2.5mg | $195 | 2021-12-16 | Buy |
| Usbiological | 254483 | A 839977 | 870061-27-1 | 10mg | $466 | 2021-12-16 | Buy |
| TRC | A965365 | A839977 | 870061-27-1 | 1mg | $85 | 2021-12-16 | Buy |
A 839977 Chemical Properties,Uses,Production
Uses
A 839977 is a selective P2X7 receptor antagonist.
Biological Activity
a839977 is a novel and selective antagonist of p2x7 receptor with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively [1].a839977 has been reported to block bzatp-evoked changes in intracellular calcium concentrations in 132n1 cells stable expressing p2x7 receptors with the ic50 values of 20 nm, 42nm and 150nm for human, rat and mouse, respectively. in addition, a839977 has also revealed to inhibit bzatp-stimulated il-1β release and yo-pro uptake with the ic50 of 37nm and 7nm, respectively, in differentiated human thp-1 cells. besides, a839977 has been noted to produce parallel rightward shifts in bzatp concentration-effect calcium influx curves with the paα value of 8.1. apart from these, a839977 has been exhibited to reduce cfa-induced thermal hyperalgesia in a dose-dependent fashion with the ed50 value of 100μmol/kg(i.p.) [1].
storage
Store at +4°C
References
[1] honore p1, donnelly-roberts d, namovic m, zhong c, wade c, chandran p, zhu c, carroll w, perez-medrano a, iwakura y, jarvis mf. the antihyperalgesic activity of a selective p2x7 receptor antagonist, a-839977, is lost in il-1alphabeta knockout mice. behav brain res. 2009 dec 1;204(1):77-81.
A 839977 Preparation Products And Raw materials
Raw materials
Preparation Products
A 839977 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10006 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |