Voreloxin
- CAS No.
- 175414-77-4
- Chemical Name:
- Voreloxin
- Synonyms
- SPC-595;SNS-595;AG-7352;CS-1489;VOSAROXIN;Voreloxin;Voreloxin, >=98%;Voreloxin (SNS-595);Voreloxin USP/EP/BP;SNS-595; VOSAROXIN; AG 7352
- CBNumber:
- CB92538816
- Molecular Formula:
- C18H19N5O4S
- Molecular Weight:
- 401.44
- MDL Number:
- MFCD13185156
- MOL File:
- 175414-77-4.mol
- MSDS File:
- SDS
| Boiling point | 652.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; insoluble in DMSO |
| form | solid |
| pka | 5.68±0.70(Predicted) |
| FDA UNII | K6A90IIZ19 |
| NCI Drug Dictionary | vosaroxin |
| ATC code | L01XX53 |
Voreloxin price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | V759000 | Voreloxin | 175414-77-4 | 2.5mg | $165 | 2021-12-16 | Buy |
| TRC | V759000 | Voreloxin | 175414-77-4 | 25mg | $965 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181346 | Voreloxin >98% | 175414-77-4 | 100mg | $1133.9 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 42621 | Voreloxin | 175414-77-4 | 25mg | $1375 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181346 | Voreloxin >98% | 175414-77-4 | 250mg | $1949.9 | 2021-12-16 | Buy |
Voreloxin Chemical Properties,Uses,Production
Uses
Voreloxin is a potent Topoisomerase II inhibitor with broad-spectrum anti-tumor activity.
Biological Activity
voreloxin, formerly known as sns-595 or ag-7352, is a novel naphthyridine analog, which is structurally related to the quinolone antibiotics, a chemical class not previously used for the treatmentof cancer.
in vitro
in vitro studies demonstrated voreloxin has broad anti-proliferative activity in 11 tumor cell lines, with ic50 values ranging from 0.04 to 0.97 μm. similar activity was observed in vitro in drug-resistant cell lines, including those that overexpress p-glycoprotein [2].
in vivo
after a single intravenous dose, voreloxin concentrations in tumor were correlated with induction of the apoptosis marker caspase-3. administration of voreloxin at 20 mg/kg weekly inhibited tumor growth (86%). voreloxin demonstrated strong dose-dependent tumor growth inhibition (63–88%) in 10 of 11 solid tumor xenograft models [2].
References
[1] tsuzuki y, tomita k, shibamori k, sato y, kashimoto s, chiba k. synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. part 2. j med chem. 2004;47(8):2097-109.
[2] hoch u, lynch j, sato y, kashimoto s, kajikawa f, furutani y, silverman ja. voreloxin, formerly sns-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models. cancer chemother pharmacol. 2009;64(1):53-65.
[3] advani rh, hurwitz hi, gordon ms, ebbinghaus sw, mendelson ds, wakelee ha, hoch u, silverman ja, havrilla na, berman cj, fox ja, allen rs, adelman dc. voreloxin, a first-in-class anticancer quinolone derivative, in relapsed/refractory solid tumors: a report on two dosing schedules. clin cancer res. 2010;16(7):2167-75.
Voreloxin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from Voreloxin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Voreloxin
175414-77-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Voreloxin
175414-77-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-07-06 | Voreloxin
175414-77-4
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |