ChemicalBook >> CAS DataBase List >>2,5-DiMethyl Celecoxib
2,5-DiMethyl Celecoxib
- CAS No.
- 457639-26-8
- Chemical Name:
- 2,5-DiMethyl Celecoxib
- Synonyms
- Celecoxib-13;5-dimethyl Celecoxib;Celecoxib Impurity K;Celecoxib impurity T;Celecoxib Impurity 42;Celecoxib 2,5-Dimethyl;2,5-DiMethyl Celecoxib;2,5-DiMethyl-celecoxib DMC;2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib;4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
- CBNumber:
- CB92543122
- Molecular Formula:
- C18H16F3N3O2S
- Molecular Weight:
- 395.4
- MDL Number:
- MFCD19443858
- MOL File:
- 457639-26-8.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
2,5-DiMethyl Celecoxib price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D7196 | 2,5-Dimethyl-celecoxib ≥98% (HPLC) | 457639-26-8 | 5mg | $40 | 2024-03-01 | Buy |
| Sigma-Aldrich | 35342 | 2,5-Dimethyl-celecoxib VETRANAL , analytical standard | 457639-26-8 | 10mg | $134 | 2021-12-16 | Buy |
| Cayman Chemical | 10008006 | 2,5-dimethyl Celecoxib | 457639-26-8 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 10008006 | 2,5-dimethyl Celecoxib | 457639-26-8 | 10mg | $92 | 2024-03-01 | Buy |
| Sigma-Aldrich | D7196 | 2,5-Dimethyl-celecoxib ≥98% (HPLC) | 457639-26-8 | 25mg | $407 | 2024-03-01 | Buy |
2,5-DiMethyl Celecoxib Chemical Properties,Uses,Production
Uses
2,5-Dimethyl-celecoxib has been used
- To block the synthesis of prostaglandin E2 and to study effect of transforming growth factor-2 signaling towards cyclooxygenase-2 expression.
- In an in vitro study to analyze its pro-oxidative capacities in metastatic melanoma/ breast cancer cells.
- To study its interaction between silymarin on chemically induced osteoarthritis in rats.
Uses
A non-cyclooxygenase-2 inhibitor analog of Celecoxib (C251000). The celecoxib analog, 2,5-di-Me celecoxib (DMC), lacks COX-2 inhibitory activity but exhibits cytotoxic properties comparable to the COX-2 inhibitor Celecoxib.
Biochem/physiol Actions
Celecoxib, and the inactive analog 2′,5′-dimethyl celecoxib both induce apoptosis in a many cancer cell lines by down-regulating the expression of survivin. This activiy is mediated via an AKT mediated pathway, and is unique to this class of cyclo-oxygenase inhibitors, as non-selective NSAIDs or other COX-2 specific inhibitors such as rofecoxib, do not effect survivin expression. Unlike celecoxib, 2′,5′-dimethyl celecoxib is devoid of any inhibitory activity against COX-2.
storage
Room temperature
2,5-DiMethyl Celecoxib Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 68)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Shanghai Payne Pharmaceutical Technology Co.Ltd | 021-58123769 18678586262 | info@paynepharm.com | China | 1354 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
4-[5-(2,5-DiMethylphenyl)-3-(trifluoroMethyl)-1H-pyrazol-1-yl]benzenesulfonaMide
2,5-DiMethyl-celecoxib DMC
2,5-Dimethylcelecoxib 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
2,5-DiMethyl Celecoxib
4-[5-(2,5-Dimethyl-phenyl)-3-trifluoromethyl-pyrazol-1-yl]-benzenesulfonamide
Celecoxib-13
Celecoxib Impurity 42
Celecoxib Impurity K
Celecoxib 2,5-Dimethyl
Benzenesulfonamide, 4-[5-(2,5-dimethylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-
5-dimethyl Celecoxib
Celecoxib impurity T
2,5dimethyl Celecoxib,2,5 dimethyl Celecoxib
457639-26-8
Amines
Aromatics
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds