ChemicalBook >> CAS DataBase List >>2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid structure

CAS No.: 763114-26-7

Chemical Name:: 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid

Synonyms: EOS-61877;Olapali impurity 25;Olaparib Intermediate 1;Olaparib intermediate 763114-26-7;2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl);2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be;2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo;2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a...

CBNumber:: CB92554162

Molecular Formula:: C16H11FN2O3

Molecular Weight:: 298.27

MDL Number:: MFCD14636678

MOL File:: 763114-26-7.mol

Last updated:2024-04-15 15:30:59

Request For Quotation

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Properties

Density	1.42
storage temp.	Sealed in dry,Room Temperature
pka	3.19±0.10(Predicted)
form	powder
color	White to off-white
InChI	InChI=1S/C16H11FN2O3/c17-13-6-5-9(7-12(13)16(21)22)8-14-10-3-1-2-4-11(10)15(20)19-18-14/h1-7H,8H2,(H,19,20)(H,21,22)
InChIKey	PAXLJNGPFJEKQX-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC(CC2C3=C(C=CC=C3)C(=O)NN=2)=CC=C1F

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280
HS Code	2916399090

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	F593022	2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoicAcid	763114-26-7	5g	$95	2021-12-16	Buy
AK Scientific	Z5110	2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid	763114-26-7	10g	$101	2021-12-16	Buy
Apolloscientific	PC200051	2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid 99%	763114-26-7	25g	$105	2021-12-16	Buy
ChemScene	CS-M1900	2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid >98.0%	763114-26-7	25g	$129	2021-12-16	Buy
Apolloscientific	PC200051	2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoicacid 99%	763114-26-7	100g	$312	2021-12-16	Buy

Product number	Packaging	Price	Buy
F593022	5g	$95	Buy
Z5110	10g	$101	Buy
PC200051	25g	$105	Buy
CS-M1900	25g	$129	Buy
PC200051	100g	$312	Buy

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Chemical Properties,Uses,Production

Uses

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate used in the synthesis of phthalazinone scaffolds that are potent inhibitors of poly(ADP-ribose) polymerase, and also in the design of isocorydine derivatives with anticancer effect.

Uses

Application

2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic Acid is an intermediate in the synthesis of olaparib. Olaparib is a PARP polymerase inhibitor.

Synthesis

Synthesis_763114-26-7
Compound 3 (2.6g, 0.011mol)And 2-fluoro-5-formylbenzoic acid (2.1g, 0.012mol)Dissolved in anhydrous tetrahydrofuran (25ml), cooled to 0 ,Slowly add triethylamine (1.0ml, 0.007mol) dropwise, then warm up to room temperature for 5h, then slowly raise the temperature to 70 , add hydrazine hydrate (5.1ml, 0.107mol) for 3h, and drop to room temperature , Add appropriate amount of hydrochloric acid (2mol / L) to adjust the pH to acidic, no longer precipitate solids. Filter with suction, wash the product with water and ethyl acetate, and dry to obtain a yellow solid (1.9g, yield 83%)

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid synthesis

Synthesis of 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid from 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Preparation Products And Raw materials

Raw materials

2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile 2-FLUORO-5-FORMYLBENZOIC ACID 95 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile 2-Carboxybenzaldehyde

Preparation Products

Fluzoparib AZD2461

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Suppliers

Global( 286)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
PharmOrgSyn Laboratories Co., Ltd.	+86-021-38228826 +86-13916602830	sales@pharmorgsyn.cn	China	140	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	21-38751876 +8615000076078	info@rochipharma.com	China	431	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	+86-18616643091 +86-18616643091	info@rochipharma.com	China	246	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7534	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15371	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9350	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60

Supplier	Advantage
PharmOrgSyn Laboratories Co., Ltd.	58
Shanghai Rochi Pharmaceutical Co.,Ltd.	58
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60

View Lastest Price from 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-15	2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7	US $5.00-0.10 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2024-01-08	2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid 763114-26-7	US $9.00 / KG	1KG	99%	50000tons	Wuhan Boyuan Import & Export Co., LTD
2023-12-27	2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
763114-26-7
US $5.00-0.10 / KG
99%
Henan Fengda Chemical Co., Ltd

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicacid
763114-26-7
US $9.00 / KG
99%
Wuhan Boyuan Import & Export Co., LTD

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid
763114-26-7
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid Spectrum

2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid(763114-26-7)¹HNMR

763114-26-7(2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid)Related Search:

2-Methyl-2,4-pentanediol Cyclopentanone 2-Fluoro-5-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)benzonitrile 3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid Olaparib

CIS-BICYCLO[3.3.0]OCTANE-3,7-DIONE TERT-BUTYL 2,4-DIOXOPIPERIDINE-1-CARBOXYLATE 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzonitrile Veliparib Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride

Olaparib Impurity 12 Olaparib Impurity 29 Olaparib Impurity 32 Olaparib Impurity 27 Olaparib Impurity 21

Olaparib Impurity 23 Olaparib Impurity 24 Olaparib Impurity 28

1of4

(2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylMethyl)benzoic acid)763114-26-7 2-fluoro-5-[(4-oxo-3H-phthalazin-1-yl)Methyl]benzoic acid Benzoic acid, 5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro- 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl) 5-[(3,4-Dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluoro-Benzoic acid 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl) 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid EOS-61877 2-Fluoro-5-[(4-oxo-3,4-dihydro-1-phthalazinyl)methyl]benzoic Acid 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)be 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylm ethyl)benzo Olaparib intermediate 763114-26-7 2-Fluoro-5-(4-oxo-3,4-dihydrophthalazin-1-ylmethyl)benzoic a... C16H11FN2O3 2-fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)Methyl)benzoic acid 763114-26-7 -Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid Olaparib Intermediate 1 2-Fluoro-5-[(4-oxo-3,4-dihydrophthalazin-yl)methyl] benzoic acid Olapali impurity 25 2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoicaci 763114-26-7