MMP-13 Inhibitor
- CAS No.
- 544678-85-5
- Chemical Name:
- MMP-13 Inhibitor
- Synonyms
- DB04760;MMP-13 Inhibitor;DB04760 (DB 04760);DB04760 (COMPOUND 4);MMP-13 Inhibitor inhibitor;N,N'-Bis[(4-fluoro-3-methylphenyl)methyl]-4,6-pyrimidinedicarboxamide;4,6-Pyrimidinedicarboxamide, N4,N6-bis[(4-fluoro-3-methylphenyl)methyl]-;N4,N6-Bis(4-fluoro-3-Methylbenzyl)pyriMidine-4,6-dicarboxaMide
- CBNumber:
- CB92602854
- Molecular Formula:
- C22H20F2N4O2
- Molecular Weight:
- 410.42
- MDL Number:
- MFCD09878513
- MOL File:
- 544678-85-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 29335990 |
MMP-13 Inhibitor price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19540 | MMP-13 Inhibitor ≥98% | 544678-85-5 | 1mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 19540 | MMP-13 Inhibitor ≥98% | 544678-85-5 | 5mg | $355 | 2024-03-01 | Buy |
| Cayman Chemical | 19540 | MMP-13 Inhibitor ≥98% | 544678-85-5 | 10mg | $601 | 2024-03-01 | Buy |
| ApexBio Technology | C4331 | MMP-13Inhibitor | 544678-85-5 | 10mg | $686 | 2021-12-16 | Buy |
| AK Scientific | Z3393 | Pyrimidine-4,6-dicarboxylicacidbis-(4-fluoro-3-methyl-benzylamide) | 544678-85-5 | 10mg | $768 | 2021-12-16 | Buy |
MMP-13 Inhibitor Chemical Properties,Uses,Production
Description
MMP-13 Inhibitor is a pyrimidine dicarboxamide that inhibits matrix metalloproteinase-13 (MMP-13, also known as collagenase-3) with an IC50 value of 8 nM. MMP-13 Inhibitor binds to pockets that are unique to MMP-13, rather than the catalytic zinc, and thus is specific for MMP-13 over other MMPs. MMP-13 Inhibitor blocks osterix-dependent calcification of matrices in limb bud cells during endochondral ossification.
Chemical Properties
White crystal
in vitro
mmp-13 inhibitor was previously synthesized as a pyrimidine dicarboxamide that could inhibit the matrix metalloproteinase-13 (mmp-13) with the ic50 of 8 nm. moreover, mmp-13 inhibitor was found to be able to bind to mmp pockets that are unique to mmp-13 rather than the catalytic zinc, and therefore was specific for mmp-13 over other mmps. in addition, during endochondral ossification, mmp-13 inhibitor could also block osterix-dependent calcification of matrices in limb bud cells [1, 2, 3].
IC 50
8 nm
References
1. carrascal, n.a. and rizzo, r.c. calculation of binding free energies for non-zinc chelating pyrimidine dicarboxamide inhibitors with mmp-13. bioorg.med.chem.lett. 19(1), (2009).2. engel, c.k.,pirard, b.,schimanski, s., et al. structural basis for the highly selective inhibition of mmp-13. chem.biol. 12(2), 181-189 (2005).3. nishimura, r.,wakabayashi, m.,hata, k., et al. osterix regulates calcification and degradation of chondrogenic matrices through matrix metalloproteinase 13 (mmp13) expression in association with transcription factor runx2 during endochondral ossification. j.biol.chem. 287(40), 33179-33190 (2012).
MMP-13 Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Alabiochem Tech.Co., Ltd. | 0512-58900862 400-0707518 | sales@alabiochem.com | China | 995 | 59 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |