EPZ004777
- CAS No.
- 1338466-77-5
- Chemical Name:
- EPZ004777
- Synonyms
- PEZ4777;CS-1932;EPZ 4777;EPZ-4777;EPZ004777;EPZ004777 USP/EP/BP;EPZ 004777;EPZ-004777;EPZ004777 (formic acid salt);DOT1L Inhibitor EPZ004777 EPZ-004777;EPZ004777; EPZ 004777; EPZ-004777;PEZ4777;EPZ 4777;EPZ-4777
- CBNumber:
- CB92614846
- Molecular Formula:
- C28H41N7O4
- Molecular Weight:
- 539.67
- MDL Number:
- MFCD25563264
- MOL File:
- 1338466-77-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
EPZ004777 price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 16173 | EPZ004777 (formic acid salt) ≥98% | 1338466-77-5 | 500μg | $25 | 2021-12-16 | Buy |
Cayman Chemical | 16173 | EPZ004777 (formic acid salt) ≥98% | 1338466-77-5 | 1mg | $45 | 2021-12-16 | Buy |
Cayman Chemical | 16173 | EPZ004777 (formic acid salt) ≥98% | 1338466-77-5 | 5mg | $180 | 2021-12-16 | Buy |
Cayman Chemical | 16173 | EPZ004777 (formic acid salt) ≥98% | 1338466-77-5 | 10mg | $235 | 2021-12-16 | Buy |
Tocris | 5567 | EPZ004777 ≥98%(HPLC) | 1338466-77-5 | 10 | $279 | 2021-12-16 | Buy |
EPZ004777 Chemical Properties,Uses,Production
Uses
EPZ 004777 is potent small molecule inhibitor of protein lysine methyltransferase DOT1L.
Definition
ChEBI: 1-[3-[[(2R,3S,4R,5R)-5-(4-amino-7-pyrrolo[2,3-d]pyrimidinyl)-3,4-dihydroxy-2-oxolanyl]methyl-propan-2-ylamino]propyl]-3-(4-tert-butylphenyl)urea is a N-glycosyl compound.
Biological Activity
epz004777 is a specific small-molecule h3k79 methyltransferase dot1l inhibitor that potently inhibits dot1l in a radionuclide homogeneous assay with the half maximal inhibition concentration ic50 value of 400 pm and selectively kills a variety of mll-rearranged leukemia cells, including an mll-af4 leukemia cell line mv4-11 and an mll-af9 leukemia cell line molm13 [1 & 2].epz004777 has also been found to selectively inhibit the proliferation of mll-af10 and calm-af10 transformed cells in a dose dependent manner (ic50: 0.1 μm to 1 μm), in which the mrna expression levels of two hallmark leukemogenic genes (hoxa9 and meis1) are suppressed by epz004777 in a concentration dependent manner [2].
storage
Store at -20°C
EPZ004777 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3581 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10026 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
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