ENMD-2076 (Tartrate)
- CAS No.
- 1291074-87-7
- Chemical Name:
- ENMD-2076 (Tartrate)
- Synonyms
- ENMD-2076 (Tartrate);ENMD-2076 L-(+)-Tartaric acid;ENMD-2076 tartrate (ENMD 2076;(E)-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine,L-(+)-Tartaric acid
- CBNumber:
- CB92624137
- Molecular Formula:
- C21H25N7.x(C4H6O6)
- Molecular Weight:
- 0
- MDL Number:
- MFCD18074523
- MOL File:
- Mol file
ENMD-2076 (Tartrate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | A4129 | ENMD-2076L-(+)-Tartaricacid | 1291074-87-7 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-0210 | ENMD-2076Tartrate 98.87% | 1291074-87-7 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A4129 | ENMD-2076L-(+)-Tartaricacid | 1291074-87-7 | 50mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0210 | ENMD-2076Tartrate 98.87% | 1291074-87-7 | 10mg | $180 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611816 | ENMD-2076 tartrate | 1291074-87-7 | 10mg | $210.8 | 2021-12-16 | Buy |
ENMD-2076 (Tartrate) Chemical Properties,Uses,Production
Uses
ENMD-2076 (ENMD-981693, ENMD2076) is a antiangiogenic and Aurora kinase inhibitor with IC50 of 3, 13, 350, 23, 40, 93 and 120 nM for Flt-3, AurA, AurB, Src, KDR/VEGFR2 and FGFR1.
Biological Activity
enmd-2076 is an orally bioavailable, small molecule inhibitor of aurora kinases with ic50 values of 14nm and 350nm, respectively against aurora kinase a and aurora kinase b [1].besides aurora kinases, enmd-2076 inhibits multiple kinases involved in various cellular activities. overexpression of aurora kinase a has been found in breast cancers and enmd-2076 is thereby studied in breast cancers. it is reported that enmd-2076 differentially inhibits 29 breast cancer cell lines with ic50 values ranged from 0.25 to 16.1μm. in the clonogenic assays, enmd-2076 totally suppresses the colony formation in the sensitivemda-mb-468 cell line and decreases the formation in thehcc1806, sk-br-3, and bt474 cell lines. enmd-2076 is also reported to cause a g2 cell-cycle arrest at 1.25μm. moreover, enmd-2076 shows antitumor activity in tnbc xenograft models. apart from the breast cancers, enmd-2076 is developed in hematological malignancies therapy. the
References
[1] diamond jr, eckhardt sg, tan ac, newton tp, selby hm, brunkow kl, kachaeva mi, varella-garcia m, pitts tm, bray mr, fletcher gc, tentler jj. predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor enmd-2076 in preclinical breast cancer models. clin cancer res. 2013 jan 1;19(1):291-303.
[2] how j, yee k. enmd-2076 for hematological malignancies. expert opin investig drugs. 2012 may;21(5):717-32.
ENMD-2076 (Tartrate) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |