Umeclidinium bromide
- CAS No.
- 869113-09-7
- Chemical Name:
- Umeclidinium bromide
- Synonyms
- CS-1562;GSK573719A;UMeclidiuM;Umeclidiniu;umeclidinium;UMeclidiniuM broMide;Umeclinidium bromide;Jmechlidinium bromide;Umeclidinium(GSK573719A);UMeclidiniuM BroMide (API)
- CBNumber:
- CB92625301
- Molecular Formula:
- C29H34BrNO2
- Molecular Weight:
- 508.48976
- MDL Number:
- MFCD27976798
- MOL File:
- 869113-09-7.mol
| Melting point | >231°C (dec.) |
|---|---|
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Stability | Hygroscopic |
| FDA UNII | 7AN603V4JV |
| ATC code | R03BB07 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H410-H400-H302-H332 | |||||||||
| Precautionary statements | P273-P391-P501-P273-P391-P501-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312 | |||||||||
| NFPA 704 |
|
Umeclidinium bromide price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20700 | Umeclidinium (bromide) ≥98% | 869113-09-7 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 20700 | Umeclidinium (bromide) ≥98% | 869113-09-7 | 50mg | $543 | 2024-03-01 | Buy |
| Cayman Chemical | 20700 | Umeclidinium (bromide) ≥98% | 869113-09-7 | 100mg | $961 | 2024-03-01 | Buy |
| TRC | U710000 | UmeclidiniumBromide | 869113-09-7 | 50mg | $645 | 2021-12-16 | Buy |
| ApexBio Technology | A3900 | Umeclidiniumbromide | 869113-09-7 | 10mg | $614 | 2021-12-16 | Buy |
Umeclidinium bromide Chemical Properties,Uses,Production
Description
Umeclidinium bromide is a long-acting muscarinic acetylcholine antagonist developed by GlaxoSmithKline and approved by the US FDA at the end of 2013 for use in combination with vilanterol, a b2 agonist, for the treatment of chronic obstructive pulmonary disease. Due to umeclidinium’s poor oral bioavailability, the drug is administrated by inhalation as dry powder.
Uses
Umeclidinium Bromide is considered as a potentially long-acting antimuscarinic agent.
Definition
ChEBI: A quaternary ammonium salt that is the bromide salt of umeclidinium. Used in combination with vilanterol for long-term maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease.
Synthesis
Commercially available ethyl isonipecotate (278) was alkylated with 1-bromo-2-chloroethane in the presence of K2CO3 in acetone to give ethyl 1-(2-chloroethyl)piperidine-4-carboxylate (279). This material was then treated with lithium diisopropylamine (LDA) in THF to affect a transannular substitution reaction resulting in the cyclized quinuclidine 280 in 96% yield. Excess of phenyllithium was added to ester 280 in THF starting at low temperature then gradually warming to room temperature to give tertiary alcohol 281 in 61% yield. Amine 281 was finally alkylated with benzyl 2- bromoethyl ether (282) in MeCN/CHCl3 at elevated temperatures to afford umeclidinium bromide (XXXV) in 69% yield.
References
[1] salmon m, luttmann m a, foley j j, et al. pharmacological characterization of gsk573719 (umeclidinium): a novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseases. journal of pharmacology and experimental therapeutics, 2013, 345(2): 260-270.
Umeclidinium bromide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Dexinjia Biopharm Co., Ltd | +86-531-82375818 +86-15064153060 | alice@jndxj.com | China | 309 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8619956560829 | justine@zhongda-biotech.com | China | 300 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7377 | 58 |
| Wuhan Xinhao Biotechnology Co., Ltd | +86-18120578002 +86-18120578002 | xinhao-6@xinhaoshengwu.com | China | 350 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
View Lastest Price from Umeclidinium bromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | Umeclidinium bromide
869113-09-7
|
US $5.00-0.10 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-04-10 | Umeclidinium Bromide
869113-09-7
|
US $0.00-0.00 / Kg/Bag | 1Kg/Bag | 0.99 | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-04-02 | Umeclidinium bromide
869113-09-7
|
US $10.00-100.00 / kg | 1kg | 99% | 100 tons | Wuhan Xinhao Biotechnology Co., Ltd |
-
- Umeclidinium bromide
869113-09-7
- US $5.00-0.10 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Umeclidinium Bromide
869113-09-7
- US $0.00-0.00 / Kg/Bag
- 0.99
- Sinoway Industrial co., ltd.
-
- Umeclidinium bromide
869113-09-7
- US $10.00-100.00 / kg
- 99%
- Wuhan Xinhao Biotechnology Co., Ltd