tiraseMtiv (CK-2017357)
- CAS No.
- 1005491-05-3
- Chemical Name:
- tiraseMtiv (CK-2017357)
- Synonyms
- CS-1484;TiraseMtiv;CK 2017357;Tirasemitiv;Tirasemtiv, >=98%;tiraseMtiv (CK-2017357);Tirasemtiv(CK-2017357), >98%;CK-2017357; CK2017357; CK 2017357;inhibit,Tirasemtiv,Inhibitor,CK2017357,CK 2017357;5-ethynyl-3-pentan-3-yl-1H-imidazo[4,5-b]pyrazin-2-one
- CBNumber:
- CB92631164
- Molecular Formula:
- C12H14N4O
- Molecular Weight:
- 230.27
- MDL Number:
- MFCD28023588
- MOL File:
- 1005491-05-3.mol
| Melting point | >130°C (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Beige to Brown |
| FDA UNII | G8WSM7R635 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
tiraseMtiv (CK-2017357) price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26075 | Tirasemtiv ≥98% | 1005491-05-3 | 5mg | $47 | 2024-03-01 | Buy |
| Cayman Chemical | 26075 | Tirasemtiv ≥98% | 1005491-05-3 | 10mg | $84 | 2024-03-01 | Buy |
| Cayman Chemical | 26075 | Tirasemtiv ≥98% | 1005491-05-3 | 25mg | $182 | 2024-03-01 | Buy |
| Cayman Chemical | 26075 | Tirasemtiv ≥98% | 1005491-05-3 | 50mg | $272 | 2024-03-01 | Buy |
| TRC | T446700 | Tirasemtiv | 1005491-05-3 | 25mg | $150 | 2021-12-16 | Buy |
tiraseMtiv (CK-2017357) Chemical Properties,Uses,Production
Description
Tirasemtiv is an activator of the fast skeletal troponin complex. It selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes. Tirasemtiv (20 μM) slows the rate of calcium release from the fast skeletal troponin complex. It increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM) and sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium in a concentration-dependent manner. Tirasemtiv increases in situ extensor digitorum longus (EDL) muscle force and forelimb grip strength in a rat model of myasthenia gravis. It also increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of amyotrophic lateral sclerosis (ALS) when administered at a dose of 10 mg/kg.
Uses
Tirasemtiv is a fast skeletal muscle troponin activator and is used for treating patients with amyotrophic lateral sclerosis (ALS).
tiraseMtiv (CK-2017357) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Wuhan Nutra Biotechnology Co.,Ltd | +8617786394783 | nutrabiotech@outlook.com | China | 300 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from tiraseMtiv (CK-2017357) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-08 | Tirasemtiv;CK-2017357
1005491-05-3
|
US $500.00-0.00 / g | 1g | 98%+ | 100kgs | Wuhan Nutra Biotechnology Co.,Ltd | |
 |
2019-07-06 | tiraseMtiv (CK-2017357)
1005491-05-3
|
US $1.00 / KG | 1KG | 95% | 200KG | Career Henan Chemical Co |
-
- Tirasemtiv;CK-2017357
1005491-05-3
- US $500.00-0.00 / g
- 98%+
- Wuhan Nutra Biotechnology Co.,Ltd
-
- tiraseMtiv (CK-2017357)
1005491-05-3
- US $1.00 / KG
- 95%
- Career Henan Chemical Co