ChemicalBook >> CAS DataBase List >>EGT1442
EGT1442
- CAS No.
- 1118567-05-7
- Chemical Name:
- EGT1442
- Synonyms
- CS-250;CS-2165;EGT1442;THR1442;THR 1442;THR-1442;EGT0001442;EGT-0001442;EGT 0001442;Bexgliflozin
- CBNumber:
- CB92650633
- Molecular Formula:
- C24H29ClO7
- Molecular Weight:
- 464.94
- MDL Number:
- MFCD28100944
- MOL File:
- 1118567-05-7.mol
- MSDS File:
- SDS
Last updated:2024-02-23 12:06:14
Boiling point | 671.0±55.0 °C(Predicted) |
---|---|
Density | 1.41 |
storage temp. | Store at -20°C |
solubility | DMSO:100.0(Max Conc. mg/mL);215.08(Max Conc. mM) |
form | A crystalline solid |
pka | 13.23±0.70(Predicted) |
FDA UNII | EY00JF42FV |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
NFPA 704 |
|
EGT1442 price More Price(17)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 5mg | $139 | 2024-03-01 | Buy |
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 10mg | $243 | 2024-03-01 | Buy |
Cayman Chemical | 21359 | EGT-1442 ≥95% | 1118567-05-7 | 25mg | $533 | 2024-03-01 | Buy |
TRC | B336785 | Bexagliflozin3 | 1118567-05-7 | 10mg | $310 | 2021-12-16 | Buy |
EGT1442 Chemical Properties,Uses,Production
Description
EGT-1442 is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 5.6 μM and 2 nM for human SGLT1 and SGLT2, respectively. It produces a stable urinary excretion of glucose in rats and dogs with ED50 values of 0.38 and 0.09 mg/kg, respectively, and reduces HbA(1c) and blood glucose in db/db mice in a concentration dependent manner.
Uses
Bexagliflozin, also known as EGT1442, is a potent and selective SGLT2 inhibitor, attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.
Synthesis of EGT1442 from (3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
EGT1442 Preparation Products And Raw materials
Raw materials
2-Cyclopropoxyethyl4-methylbenzenesulfonate
2-(2-Bromoethyl)-1,3-dioxolane
(3R,4S,5S,6R)-2-(4-chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol
((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate
4-broMo-1-chloro-2-(4-(2-cyclopropoxyethoxy)benzyl)benzene
1of2
Preparation Products
Global( 97)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 | info@millionpharm.com | China | 153 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12468 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1472 | 58 |
View Lastest Price from EGT1442 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-25 | Bexagliflozin
1118567-05-7
|
US $2.00 / kg | 0.10000000149011612kg | 99% | 200KG | Jinan Million Pharmaceutical Co., Ltd | ||
2024-02-23 | Bexagliflozin
1118567-05-7
|
US $380.00 / g | 1g | 99 | 50 Kg | R&D Scientific Inc. | ||
2019-07-06 | EGT1442
1118567-05-7
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
- Bexagliflozin
1118567-05-7
- US $2.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
- Bexagliflozin
1118567-05-7
- US $380.00 / g
- 99
- R&D Scientific Inc.
- EGT1442
1118567-05-7
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
EGT1442
(1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-D-glucitol
Bexagliflozin
EGT1442(Bexagliflozin,THR1442)
Bexagliflozin,EGT1442
CS-2165
EGT 0001442
EGT0001442
EGT-0001442
EGT1442; THR1442; EGT0001442; EGT-1442; THR-1442; EGT-0001442; EGT 1442; THR 1442; EGT 0001442
THR 1442
THR1442
THR-1442
CS-250
Bexagliflozin(THR1442,EGT1442)|
BEXAGLIFLOZIN;EGT-1442;THR1442;EGT0001442;EGT-1442;THR-1442;EGT-0001442;EGT 1442;THR 1442;EGT 0001442
Bexagliflozin (THR1442)
D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)-
Bexagliflozin3
Bexgliflozin
(2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-(2-cyclopropoxyethoxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
Bexagliflozin Impurity 1
Bexgliflozin Impurity 1
Bexgliflozin (EGT1442)
1118567-05-7