CATHEPSIN D
- CAS No.
- 9025-26-7
- Chemical Name:
- CATHEPSIN D
- Synonyms
- EC 3.4.23.5;EC 3.4.22.5;CATHEPSIN D;Cathepsins D;CATHEPSIN D, HUMAN;CATHEPSIN D, BOVINE;CATHEPSIN D, HUMAN LIVER;Native Human Cathepsin D;CATHEPSIN D, HUMAN SPLEEN;Native Bovine Cathepsin D
- CBNumber:
- CB9265367
- Molecular Formula:
- NULL
- Molecular Weight:
- 0
- MDL Number:
- MFCD02662346
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | lyophilized powder |
| color | white |
| Water Solubility | Reconstitute in water at 1µg/µl |
| FDA UNII | MF0G4WBC26 |
CATHEPSIN D price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C3138 | Cathepsin D from bovine spleen lyophilized powder, ≥2.0?units/mg protein | 9025-26-7 | 5UNITS | $289 | 2024-03-01 | Buy |
| Sigma-Aldrich | C8696 | Cathepsin D from human liver lyophilized powder, ≥250?units/mg protein (E1%/280) | 9025-26-7 | 25μg | $373 | 2024-03-01 | Buy |
| Sigma-Aldrich | C3138 | Cathepsin D from bovine spleen lyophilized powder, ≥2.0?units/mg protein | 9025-26-7 | 10UNITS | $493 | 2024-03-01 | Buy |
| Sigma-Aldrich | C3138 | Cathepsin D from bovine spleen lyophilized powder, ≥2.0?units/mg protein | 9025-26-7 | 20UNITS | $875 | 2024-03-01 | Buy |
| Sigma-Aldrich | C3138 | Cathepsin D from bovine spleen lyophilized powder, ≥2.0?units/mg protein | 9025-26-7 | 40UNITS | $1540 | 2023-01-07 | Buy |
CATHEPSIN D Chemical Properties,Uses,Production
Uses
Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer.
Uses
Cathepsin D from human liver has been used:
- in β-secretase activity assay
- for enzymatic degradation of amyloid β 1-42
- in microinjection of human foreskin fibroblasts
General Description
Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis.
Biochem/physiol Actions
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Purification Methods
Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960].
CATHEPSIN D Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| Guangzhou Tomums Life Science Co., Ltd. | 020-31155029 18902330969 | sales@tomums.cn | China | 4698 | 58 |
| Lingyuan Bebiansen Biological Technology Co., Ltd | 18642120371 | 2837458851@qq.com | China | 9936 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29803 | 58 |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | sales@shzbio.com | China | 9965 | 58 |
| Shanghai Guchen Biotechnology Co., LTD | 021-34675735 19147740836 | 1986399151@qq.com | China | 9849 | 58 |
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