A 438079 (hydrochloride)
- CAS No.
- 899431-18-6
- Chemical Name:
- A 438079 (hydrochloride)
- Synonyms
- A-438079 HCl;A-438079;A438079;A 438079;3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine monohydrochloride;P2X Receptor,A-438079,P2XRs,A 438079 hydrochloride,A438079,Inhibitor,inhibit,A 438079
- CBNumber:
- CB92666582
- Molecular Formula:
- C13H10Cl3N5
- Molecular Weight:
- 342.611
- MDL Number:
- MFCD09971142
- MOL File:
- 899431-18-6.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
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---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
NFPA 704 |
|
A 438079 (hydrochloride) price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 14580 | A-438079 (hydrochloride) ≥98% | 899431-18-6 | 10mg | $168 | 2024-03-01 | Buy |
Cayman Chemical | 14580 | A-438079 (hydrochloride) ≥98% | 899431-18-6 | 50mg | $570 | 2024-03-01 | Buy |
Cayman Chemical | 14580 | A-438079 (hydrochloride) ≥98% | 899431-18-6 | 5mg | $89 | 2024-03-01 | Buy |
Cayman Chemical | 14580 | A-438079 (hydrochloride) ≥98% | 899431-18-6 | 25mg | $330 | 2024-03-01 | Buy |
TRC | D436095 | 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridineHydrochloride | 899431-18-6 | 5mg | $100 | 2021-12-16 | Buy |
A 438079 (hydrochloride) Chemical Properties,Uses,Production
Description
A-
Uses
3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine is a 1-Benzyl-5-aryltetrazole derivative and potential antagonists for the P2X7 receptor.
in vitro
In 1321N1 cells stably expressing rat P2X 7 receptors, A 438079 blocks BzATP-(10 μM) evoked changes in intracellular calcium concentrations with an IC 50 of 321 nM. A 438079 is also selective for the P2X 7 receptor, at concentrations up to 100 μM.
in vivo
A 438079 (80 μmol/kg, i.v.) reduces noxious and innocuous evoked activity of different classes of spinal neurons in neuropathic rats. A 438079 (100 and 300 μmol/kg, i.p.) signi?cantly raises withdrawal thresh-olds in both the SNL and CCI models. Intraperitoneal injection of A 438079 (5 and 15 mg/kg) 60 min after triggering seizures reduces seizure severity and neuronal death within the hippocampus. A 438079 has superior neuroprotective effects compared with an equally dose of phenobarbital (25 mg/kg). A 438079 partially but signi?cantly prevents the 6-OHDA-induced depletion of striatal DA stores. Pretreatment with A 438079 reduces nociceptive behaviour scores in the HC model.
storage
Desiccate at RT
References
Nelson et al. (2006) Structure-activity relationship studies on a series of novel, substitutes 1-benzyl-5-phenyltetrazole P2X7 antagonists; J. Med. Chem. 49 3659 McGaraughty et al. (2007) P2X7-related modulation of pathological nociception in rats; Neuroscience 146 1817 Clark et al. (2010) P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide; J. Neurosci. 30 573 Kobayashi et al. (201) Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model; Neurosci. Lett. 504 57 Chu et al. (2012) Inhibition of P2X7 receptor ameliorates transient global cerebral ischemia/reperfusion injury via modulating inflammatory responses in the rat hippocampus; J. Neuroinflammation 9 69
A 438079 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4647 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
View Lastest Price from A 438079 (hydrochloride) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-01-06 | A 438079 (hydrochloride)
899431-18-6
|
US $0.01 / KG | 1KG | 95%-99% | 1kg; 5kg; 10kg | Career Henan Chemica Co |
- A 438079 (hydrochloride)
899431-18-6
- US $0.01 / KG
- 95%-99%
- Career Henan Chemica Co