ARN-2966
- CAS No.
- 102212-26-0
- Chemical Name:
- ARN-2966
- Synonyms
- 2-PMAP;ARN-2966;ARN2966(2-PMAP);ARN-2966;ARN 2966;2-PMAP >=98% (HPLC);2-((pyridin-2-ylmethyl)amino)phenol;Phenol, 2-[(2-pyridinylmethyl)amino]-;ARN-2966,β-amyloid peptide,inhibit,Abeta,ARN 2966,Inhibitor,Amyloid-β,ARN2966
- CBNumber:
- CB92667271
- Molecular Formula:
- C12H12N2O
- Molecular Weight:
- 200.24
- MDL Number:
- MFCD24550644
- MOL File:
- 102212-26-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| NFPA 704 |
|
ARN-2966 price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21021 | 2-PMAP | 102212-26-0 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21021 | 2-PMAP | 102212-26-0 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 21021 | 2-PMAP | 102212-26-0 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 21021 | 2-PMAP | 102212-26-0 | 25mg | $396 | 2024-03-01 | Buy |
| AK Scientific | SYN5152 | 2-PMAP | 102212-26-0 | 50mg | $765 | 2021-12-16 | Buy |
ARN-2966 Chemical Properties,Uses,Production
Biological Activity
arn2966 is a potent post-transcriptional modulator of amyloid precursor protein (app) expression in transfected cho cells. the cho cell can produce app.[1]app is the amyloid precursor protein of alzheimer’s disease. alzheimer’s disease is a progressive dementia with the symptoms of neuronal degeneration, synaptic loss, and the deposition of amyloid fibrils in the brain. ab protein is the major constituent of the amyloid . then the ab protein derives from the amyloid precursor protein (app). it has been proved that app can stimulate neurite outgrowth in vitro. [2]the modulation of app expression of the arn2966 functions as a post-transcriptional modulation,which is different from other mechanisms such as inhibition of secretases. arn2966 showed dose dependant inhibition of aß40 and aß42 productions in app751sw transfected cho cells (ic50<1 mm for aß40), along with lowering the level of app and c83, and c99 peptides, while the level of app mrna was unaffected..[1]there has been ad transgenic mice model proved arn2966’s efficacy and tolerability in vivo. through the treatment of arn2966, the memory of mice has been improved and a load in the brain has been reduced.
References
[1] ayodeji asuni ,xu kevin , etal. , an app translation modulator arn2966 reduces beta-amyloid deposition and prevents memory deficits in alzheimer's disease transgenic mice. alzheimer's & dementia: the journal of the alzheimer's association, july 2012volume 8, issue 4, supplement, page s744 ;
[2]williamson tg1, mok ss, henry a, etal. , secreted glypican binds to the amyloid precursor protein of alzheimer's disease (app) and inhibits app-induced neurite outgrowth. j biol chem. 1996 dec 6;271(49):31215-21.
ARN-2966 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |