TOFOGLIFLOZIN
- CAS No.
- 1201913-82-7
- Chemical Name:
- TOFOGLIFLOZIN
- Synonyms
- Tofogliflozin Monohydrate;CSG452; CSG-452; TOFOGLIFLOZIN; CSG 452; UNII-554245W62TTOFOGLIFLOZIN [INN]; TOFOGLIFLOZIN ANYHYDROUS;Togliflozin;CSG 452(hydrate);Tofogliflozin(CSG452);Tofogliflozin (hydrate);TOFOGLIFLOZIN USP/EP/BP;Tofogliflozin anyhydrous;Tofogliflozin Hydrate (JAN);Tofogliflozin hydrate (1:1)
- CBNumber:
- CB92667680
- Molecular Formula:
- C22H26O6.H2O
- Molecular Weight:
- 404.46
- MDL Number:
- MFCD28385880
- MOL File:
- 1201913-82-7.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH7.2)(1:20): 0.05 mg/ml |
| form | A crystalline solid |
| FDA UNII | P8DD8KX4O4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
TOFOGLIFLOZIN price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23509 | Tofogliflozin (hydrate) ≥95% | 1201913-82-7 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23509 | Tofogliflozin (hydrate) ≥95% | 1201913-82-7 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 23509 | Tofogliflozin (hydrate) ≥95% | 1201913-82-7 | 10mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 23509 | Tofogliflozin (hydrate) ≥95% | 1201913-82-7 | 25mg | $420 | 2024-03-01 | Buy |
| ChemScene | CS-3792 | Tofogliflozin(hydrate) 98.85% | 1201913-82-7 | 10mg | $160 | 2021-12-16 | Buy |
TOFOGLIFLOZIN Chemical Properties,Uses,Production
Description
Tofogliflozin hydrate, which is a sodium-glucose co-transporter 2 inhibitor, was approved in Japan for the treatment of type 2 diabetes at the same time as luseogliflozin hydrate (XIX). The drug was discovered by Chugai Pharmaceutical and jointly developed with Sanofi-Aventis and Kowa. Tofogliflozin hydrate reduces glucose levels by inhibiting the reuptake of glucose by selectively inhibiting SGLT2, and plays a key role in the reuptake of glucose in the proximal tubule of the kidneys.
Synthesis
Reduction of commercially available 2-bromoterephtalic acid (268) through the use of trimethoxyborane and borane- THF proceeded in 89% yield to afford diol 269. Subjection of this compound to 2-methoxypropene (270) under acidic conditions generated bis-acetonide 271. This bromide then underwent lithium¨Chalogen exchange followed by exposure to magnesium bromide and treatment with lactone 272 (which was prepared by persilylation of commercially available (3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2Hpyran- 2-one (277). This mixture was worked up with aqueous ammonium chloride and upon treatment with p-TsOH in methanol resulted in spiroacetal 273. Next, global protection of all alcohol functionalities within 273 was affected by reaction with methylchloroformate and DMAP in acetonitrile. The benzyl carbonate within 274 was selectively exchanged via Suzuki coupling with 4-ethylphenylboronic acid (275) to afford methylene dibenzyl system 276. Subsequent treatment with aqueous sodium hydroxide in methanol followed by crystallization from 1:6 acetone and water furnished the desired product tofogliflozin hydrate (XXXIV) in 75% yield.
TOFOGLIFLOZIN Preparation Products And Raw materials
Raw materials
Preparation Products
TOFOGLIFLOZIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81148696 +8615536356810 | 1047@dideu.com | China | 3679 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9553 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
View Lastest Price from TOFOGLIFLOZIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-12-04 | TOFOGLIFLOZIN
1201913-82-7
|
US $216.00 / mg | 1g | 99.99% | 5ton/Month | Qiuxian Baitai New Material Co., LTD | |
 |
2021-06-08 | TOFOGLIFLOZIN USP/EP/BP
1201913-82-7
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-07-09 | TOFOGLIFLOZIN
1201913-82-7
|
US $4660.00 / KG | 1KG | 98.0% | 1T | Shaanxi Dideu Medichem Co. Ltd |
-
- TOFOGLIFLOZIN
1201913-82-7
- US $216.00 / mg
- 99.99%
- Qiuxian Baitai New Material Co., LTD
-
- TOFOGLIFLOZIN USP/EP/BP
1201913-82-7
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- TOFOGLIFLOZIN
1201913-82-7
- US $4660.00 / KG
- 98.0%
- Shaanxi Dideu Medichem Co. Ltd