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BIX 01294

BIX 01294 structure

CAS No.: 1392399-03-9

Chemical Name:: BIX 01294

Synonyms: CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL

CBNumber:: CB92677401

Molecular Formula:: C28H41Cl3N6O2

Molecular Weight:: 600.02314

MDL Number:: MFCD16618384

MOL File:: 1392399-03-9.mol

Last updated:2023-09-20 16:43:00

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BIX 01294 Properties

storage temp.	Inert atmosphere,2-8°C
solubility	H2O: >20mg/mL
form	powder
color	white
FDA UNII	57HBY4AC4W

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3
HS Code	2933.99.8290

BIX 01294 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B9311	BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder	1392399-03-9	5mg	$221	2024-03-01	Buy
Sigma-Aldrich	B9311	BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder	1392399-03-9	25mg	$525	2024-03-01	Buy
TCI Chemical	B4211	BIX 01294 Trihydrochloride Hydrate >85.0%(N)	1392399-03-9	25mg	$608	2024-03-01	Buy
TRC	B591600	BIX01294Trihydrochloride	1392399-03-9	250mg	$1175	2021-12-16	Buy
Biosynth Carbosynth	BB162787	BIX 01294	1392399-03-9	50mg	$437.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
B9311	5mg	$221	Buy
B9311	25mg	$525	Buy
B4211	25mg	$608	Buy
B591600	250mg	$1175	Buy
BB162787	50mg	$437.5	Buy

BIX 01294 Chemical Properties,Uses,Production

Uses

BIX 01294 trihydrochloride hydrate has been used:

as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
to investigate the role of G9a in neuroblastoma tumor growth
as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines

General Description

BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.

Biochem/physiol Actions

BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.

storage

room temperature (desiccate)

BIX 01294 Preparation Products And Raw materials

Raw materials

Preparation Products

BIX 01294 Suppliers

Global( 89)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3632	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29271	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei Jusheng Technology Co.,Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Nantong HI-FUTURE Biology Co., Ltd.	58

View Lastest Price from BIX 01294 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	BIX 01294 1392399-03-9	US $0.00-0.00 / KG	5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd

BIX 01294
1392399-03-9
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

BIX 01294 Spectrum

BIX 01294(1392399-03-9)¹HNMR

1392399-03-9(BIX 01294)Related Search:

Tazemetostat (EPZ-6438) GSK J4 HCl GSK 343 (2R,3R,4S,5R)-2-(6-aMino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]iMidazol-2-yl)ethyl)cyclobutyl)(isopropyl)aMino)Methyl)tetrahydrofuran-3,4-diol MM-102

OG-L002

1of2

BIX 01294 Trihydrochloride Hydrate 4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3) 2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride BIX01294 hydrochloride BIX01294 hydrochloride BIX01294 3hydrochloride Trihydrochloride Hydrate N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine BIX 01204 CS-1418 N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrochloride N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan -1-yl)-4-quinazolinamine trihydrochloride BIX 01294 Trihydrochloride Hydrate> BIX01294 HCl BIX 01294 USP/EP/BP N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride BIX01294 triHCl BIX01294 hydrochloride BIX-01294 HCL SUV39H1(H320R),BIX-01294 trihydrochloride,p21,recurrent,Cdkn1a,MLKL,H3K9me3,inhibit,Histone Methyltransferase,PRMT1,p53,Autophagy,Inhibitor,H3K9me2,BIX 01294 trihydrochloride,Gadd45a,BIX01294 trihydrochloride 1392399-03-9 C28H38N6O23HClxH2O Inhibitors