RPI-1
- CAS No.
- 269730-03-2
- Chemical Name:
- RPI-1
- Synonyms
- RPI-1;CS-2266;RPI1;RPI 1;3-(4-Hydroxybenzylidene)-5,6-dimethoxyindolin-2-one;3-[(4-hydroxyphenyl)methylidene]-5,6-dimethoxy-1H-indol-2-one;1,3-dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-H-indol-2-one;1,3-Dihydro-5,6-dimethoxy-3-[(4-hydroxyphenyl)methylene]-1H-indol-2-one;2H-Indol-2-one,1,3-dihydro-3-[(4-hydroxyphenyl)methylene]-5,6-dimethoxy-;RPI-1 (e)-n-(2-(3,4-dihydroxyphenyl)ethyl)-3-(4-hydroxyphenyl)-2-propenaMide;RET,RPI1,cells,thyroid,proliferation,phosphorylation,RPI-1,inhibit,carcinoma,oral,Inhibitor,medullary,tyrosine,kinase,RPI 1
- CBNumber:
- CB92684120
- Molecular Formula:
- C17H15NO4
- Molecular Weight:
- 297.31
- MDL Number:
- MFCD03852474
- MOL File:
- 269730-03-2.mol
| storage temp. | Sealed in dry,2-8°C |
|---|---|
| solubility | DMSO: >20mg/mL |
| form | powder to crystal |
| color | orange |
| FDA UNII | LJ66VPR7DB |
RPI-1 price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | R0202 | RPI 1 >95.0%(HPLC) | 269730-03-2 | 10mg | $118 | 2024-03-01 | Buy |
| TCI Chemical | R0202 | RPI 1 >95.0%(HPLC) | 269730-03-2 | 50mg | $401 | 2024-03-01 | Buy |
| Cayman Chemical | 20384 | RPI 1 ≥98% | 269730-03-2 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20384 | RPI 1 ≥98% | 269730-03-2 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 20384 | RPI 1 ≥98% | 269730-03-2 | 10mg | $199 | 2024-03-01 | Buy |
RPI-1 Chemical Properties,Uses,Production
Uses
RPI-?1 is RET kinase inhibitor. It can be used in biological study of composition and function of mutant Swi?/Snf complexes. It can also be used in biological study of proteomics study of medullary thyroid carcinomas expressing RET germ-line mutations and identification of new signaling elements.
Biological Activity
rpi-1 is an atp-dependent ret tyrosine kinase and inhibitor [1]. rpi-1 also inhibits c-met activation and expression [2].the ret proto-oncogene encodes a receptor protein tyrosine kinase involved in the etiology of human tumors. ret loss of function mutations are associated with the development of hirschsprung's disease, and gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias, pheochromocytoma and parathyroid hyperplasia.in nih3t3 fibroblasts expressing the ret/ptc1 target tyrosine kinase (nih3t3ptc1), rpi-1 preferentially inhibited the anchorage-independent growth with ic50 value of 0.97 μm [1]. in the n592 sclc and h460 nsclc cell lines, rpi-1 dose-dependently inhibited met phosphorylation. in h460 cells, rpi-1 also inhibited hgf-induced met tyrosine phosphorylation in a dose-dependent way [2].in mice implanted s.c. with h460 cells, rpi-1 with 100 and 150 mg/kg significantly reduced the mean number of macroscopic lung metastases by 57% and 75%, respectively. in primary s.c. growing h460 tumors, rpi-1 exhibited significant antiangiogenic effect [2].
References
[1]. lanzi c, cassinelli g, pensa t, et al. inhibition of transforming activity of the ret/ptc1 oncoprotein by a 2-indolinone derivative. int j cancer. 2000 feb 1;85(3):384-90.
[2]. cassinelli g, lanzi c, petrangolini g, et al. inhibition of c-met and prevention of spontaneous metastatic spreading by the 2-indolinone rpi-1. mol cancer ther. 2006 sep;5(9):2388-97.
RPI-1 Preparation Products And Raw materials
Raw materials
Preparation Products
RPI-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1666 | 59 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |