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4-Hydroxybenzamide

CAS No.
619-57-8
Chemical Name:
4-Hydroxybenzamide
Synonyms
4-HYDROXYBENZAMIDE;P-HYDROXYBENZAMIDE;Benzamide,p-hydroxy-;Benzamide,4-hydroxy-;4-Hydroxybenzamide>4-HYDROXYBENZAMIDE 98%;4-HYDROXYBENZAMIDE, 97+%;4-Hydroxybenzamide, 98+%;4-Hydroxy-benzoesaeure-amid;Benzamide, 4-hydroxy- (9CI)
CBNumber:
CB9271791
Molecular Formula:
C7H7NO2
Molecular Weight:
137.14
MDL Number:
MFCD00007997
MOL File:
619-57-8.mol
MSDS File:
SDS
Last updated:2023-11-01 10:41:54

4-Hydroxybenzamide Properties

Melting point 161-162 °C (lit.)
Boiling point 345.3±25.0 °C(Predicted)
Density 1.286±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka 8.60±0.13(Predicted)
color White to Light yellow to Dark green
BRN 1906921
InChI InChI=1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey QXSAKPUBHTZHKW-UHFFFAOYSA-N
SMILES C(N)(=O)C1=CC=C(O)C=C1
CAS DataBase Reference 619-57-8(CAS DataBase Reference)
FDA UNII 9OU5YD093J

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-36
WGK Germany  3
HazardClass  IRRITANT
HS Code  29242990
NFPA 704
1
2 0

4-Hydroxybenzamide price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 270253 4-Hydroxybenzamide 98% 619-57-8 5g $16.04 2024-03-01 Buy
Sigma-Aldrich 270253 4-Hydroxybenzamide 98% 619-57-8 25g $105.6 2024-03-01 Buy
TCI Chemical H0200 4-Hydroxybenzamide >98.0%(N) 619-57-8 5g $34 2024-03-01 Buy
TCI Chemical H0200 4-Hydroxybenzamide >98.0%(N) 619-57-8 25g $108 2024-03-01 Buy
Alfa Aesar B24222 4-Hydroxybenzamide, 98+% 619-57-8 5g $31.65 2024-03-01 Buy
Product number Packaging Price Buy
270253 5g $16.04 Buy
270253 25g $105.6 Buy
H0200 5g $34 Buy
H0200 25g $108 Buy
B24222 5g $31.65 Buy

4-Hydroxybenzamide Chemical Properties,Uses,Production

Chemical Properties

White to off-white crystalline powder

Uses

4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.

Uses

4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.

Definition

4-Hydroxybenzamide (4HBM) is an important biological active compound that has the presence of various biological activities such as antimycobacterial, antifungal, antimicrobial, herbicidal, and antioxidant. The benzamide derivatives are also used in medical, pharmaceutical, and therapeutic applications because of their anti-inflammatory, antibacterial, and antifungal activities. The amine and carboxylic acids are important functional groups of present molecules. These are mainly utilized in the field of chemical industry. The cocrystallization of itraconazole (a very slightly soluble triazole antifungal drug) with 4-hydroxybenzamide (4OHBZA) can potentially increase the drug solubility at pH1.2 and 37 °C by 64 times[1-2].

References

[1] Ramesh P, et al. Theoretical and experimental spectroscopic studies of monomeric and dimeric structures of 4-hydroxybenzamide International Journal of Pharmaceutics. Journal of Molecular Structure, 2020; 1206: 127742.
[2] Vasilev N, et al. Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility. International Journal of Pharmaceutics, 2021; 599: 120441.

Synthesis Reference(s)

Tetrahedron Letters, 19, p. 5183, 1978 DOI: 10.1016/S0040-4039(01)85844-5

General Description

The standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.

Source

4-Hydroxybenzamide is a natural product found in Oxytropis falcata, Houttuynia cordata, and Streptomyces tendae with data available.

99-96-7
619-57-8
Synthesis of 4-Hydroxybenzamide from 4-Hydroxybenzoic acid

4-Hydroxybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 213)Suppliers
Supplier Tel Email Country ProdList Advantage
Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
+8613601750004 lizhi@pharoschem.com China 439 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21700 55
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293 sales@sdzschem.com China 2931 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626 eric@witopchemical.com China 23556 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58

View Lastest Price from 4-Hydroxybenzamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Hydroxybenzamide pictures 2023-12-04 4-Hydroxybenzamide
619-57-8
US $0.00-0.00 / kg 0.1kg 98% 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
4-Hydroxybenzamide pictures 2023-12-04 4-Hydroxybenzamide
619-57-8
US $0.00-0.00 / kg 0.1kg 98% 100kg Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
4-Hydroxybenzamide pictures 2020-01-03 4-Hydroxybenzamide
619-57-8
US $1.00 / KG 1KG 99% 1kg-1000kg Career Henan Chemical Co
  • 4-Hydroxybenzamide pictures
  • 4-Hydroxybenzamide
    619-57-8
  • US $0.00-0.00 / kg
  • 98%
  • Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
  • 4-Hydroxybenzamide pictures
  • 4-Hydroxybenzamide
    619-57-8
  • US $0.00-0.00 / kg
  • 98%
  • Huida Pharmaceutical Technology (Shanghai) Co., Ltd.
Benzamide,4-hydroxy- Benzamide,p-hydroxy- P-HYDROXYBENZAMIDE 4-HYDROXYBENZAMIDE 4-HYDROXYBENZAMIDE (P-HYDROXYBENZAMIDE) Benzamide, 4-hydroxy- (9CI) 4-HYDROXYBENZAMIDE 98% 4-Hydroxybenzamide, 98+% 4-HYDROXYBENZAMIDE, 97+% 4-Hydroxy-benzoesaeure-amid 4-Hydroxybenzamide> 619-57-8 Organic Building Blocks Amides Building Blocks Carbonyl Compounds Amides Carbonyl Compounds Organic Building Blocks AMIDE Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts