Altiratinib
- CAS No.
- 1345847-93-9
- Chemical Name:
- Altiratinib
- Synonyms
- CS-1690;DP 5164;DCC-2701;Altiratinib;Altiratinib, >98%;Altiratinib(DCC2701);DCC2701 (Altiratinib);Altiratinib(DCC-22701);Altiratinib(DCC2701,DP5164);ALTIRATINIB; DCC2701;DCC 2701
- CBNumber:
- CB92742653
- Molecular Formula:
- C26H21F3N4O4
- Molecular Weight:
- 510.46
- MDL Number:
- MFCD28900672
- MOL File:
- 1345847-93-9.mol
- MSDS File:
- SDS
| Boiling point | 763.5±60.0 °C(Predicted) |
|---|---|
| Density | 1.557±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≥21.55 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 12.09±0.70(Predicted) |
| FDA UNII | T678746713 |
| NCI Drug Dictionary | altiratinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Altiratinib price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18777 | Altiratinib ≥98% | 1345847-93-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18777 | Altiratinib ≥98% | 1345847-93-9 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18777 | Altiratinib ≥98% | 1345847-93-9 | 10mg | $243 | 2024-03-01 | Buy |
| Cayman Chemical | 18777 | Altiratinib ≥98% | 1345847-93-9 | 25mg | $533 | 2024-03-01 | Buy |
| Usbiological | 474056 | Altiratinib | 1345847-93-9 | 100mg | $1296 | 2021-12-16 | Buy |
Altiratinib Chemical Properties,Uses,Production
Biological Activity
altiratinib (dcc-2701) is a potent inhibitor of c-met/tie-2/vegfr with ic50 values of 2.7, 8.0 and 9.2 nm, respectively [1].hepatocyte growth factor receptor (c-met) is a tyrosine kinase receptor for hepatocyte growth factor and is essential for wound healing and embryonic development. tek tyrosine kinase (tie-2) is a receptor for angiopoietin-1 (ang-1) and is important for endothelial cell-smooth muscle cell communication. vegfr is a tyrosine kinase receptor for vascular endothelial growth factor that involved in both vasculogenesis and angiogenesis.altiratinib (dcc-2701) is a potent c-met/tie-2/vegfr inhibitor. altiratinib potently inhibited met kinase and activating oncogenic met mutations and also inhibited trka, trkb and trkc kinases with ic50 values of 0.85, 4.6, and 0.83 nm, respectively. in ebc-1 nsclc and mkn-45 gastric cancer cell lines overexpressing met, altiratinib inhibited met phosphorylation with ic50 values of 0.85 and 2.2 nm, respectively. in vegf-stimulated huvecs, altiratinib inhibited vegfr2 phosphorylation with ic50 value of 4.7 nm. in huvecs and ea.hy926 cells, altiratinib inhibited tie2 phosphorylation stimulated by ang-1 with ic50 values of 1.0 and 2.6 nm, respectively [1].in the met-amplified mkn-45 xenograft model, altiratinib (30 mg/kg) inhibited met phosphorylation by >95% for the 24-hour period [1]. in nude mouse xenografted skov3 cells, dcc-2701 (10 or 20 mg/kg for 28 days) significantly reduced tumor burden by 53% and 52%, respectively [2].
References
[1]. smith bd, kaufman md, leary cb, et al. altiratinib inhibits tumor growth, invasion, angiogenesis, and microenvironment-mediated drug resistance via balanced inhibition of met, tie2, and vegfr2. mol cancer ther, 2015.
[2]. kwon y, smith bd, zhou y, et al. effective inhibition of c-met-mediated signaling, growth and migration of ovarian cancer cells is influenced by the ovarian tissue microenvironment. oncogene, 2015, 34(2): 144-153.
Altiratinib Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from Altiratinib manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-06 | Altiratinib
1345847-93-9
|
US $1.00 / KG | 1KG | 98% | 20kg | Career Henan Chemical Co |
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- Altiratinib
1345847-93-9
- US $1.00 / KG
- 98%
- Career Henan Chemical Co