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AZD6738

AZD6738
AZD6738 structure
CAS No.
1352226-88-0
Chemical Name:
AZD6738
Synonyms
AZD6738;AZD-6738;EOS-61602;AZD6738(AZD-6738);(3R)-3-Methyl-4-(6-((2R)-2-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin;(R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine;(R)-imino(methyl)(1-(6-((R)-3-methylmorpholino)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)cyclopropyl)-l6-sulfanone;4-[4-[1-[[S(R)]-S-Methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-
CBNumber:
CB92747926
Molecular Formula:
C20H24N6O2S
Formula Weight:
412.52
MOL File:
1352226-88-0.mol

AZD6738 Properties

SAFETY

AZD6738 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21035 AZD 6738 ≥98% 1352226-88-0 1mg $39 2018-11-19 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 1352226-88-0 5mg $176 2018-11-19 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 1352226-88-0 10mg $312 2018-11-19 Buy
Cayman Chemical 21035 AZD 6738 ≥98% 1352226-88-0 25mg $683 2018-11-19 Buy

AZD6738 Chemical Properties,Uses,Production

Enzyme inhibitor

This orally active, and selective ATR kinase inhibitor (FW = 412.51 g/mol; CAS 1352226-88-0; Solubility: 80 mg/mL DMSO; < 1 mg/mL H2O) targets Ataxia Telangiectasia/Rad3-related kinase (IC50 = 1 nM), a serine/threonine protein kinase that activates checkpoint signaling upon genotoxic stresses (e.g., ionizing radiation, ultraviolet light, or replication stalling), thereby serving as a DNA damage sensor. In a model consisting of primary human Chronic Myelogenous Leukemia (CL) cells with biallelic TP53 or ATM inactivation xenotransplanted into NOD/Shi- scid/IL-2Rγ mice, AZD6738 provides potent and specific inhibition of ATR signalling with compensatory activation of ATM/p53 pathway in cycling CLL cells in the presence of genotoxic stress. In p53 or ATM- defective cells, AZD6738 treatment results in replication fork stalls and accumulation of unrepaired DNA damage, as evidenced by γH2AX and 53BP1 foci formation, carried through into mitosis and resulting in cell death by mitotic catastrophe. AZD6738 displays selective cytotoxicity towards ATM- or p53-deficient CLL cells. AZD6738 also potentiates cisplatin and gemcitabine cytotoxicity in Non-Small-Cell Lung Carcinoma (NSCLC) cell lines with intact ATM kinase signaling. It also potently synergizes with cisplatin in ATM-deficient NSCLC cells. When used in combination, cisplatin and AZD6738 resolve ATM-deficient lung cancer xenografts.

AZD6738 Preparation Products And Raw materials

Raw materials

Preparation Products


AZD6738 Suppliers

Global( 51)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 QQ3435276410
474043769@qq.com China 70 58
Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2927 55
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 5984 61
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7560 61
AdooQ Bioscience CHINA 400-025-6535
025-68650336 info@adooq.cn China 3018 60
Shanghai YuanQi Biotechnology Co., Ltd. QQ:2332782371
QQ:2332782371 yuanqibiotech@qq.com China 2652 50
Shanghai Lollane Biological Technology Co.,Ltd. +86-21-52996696
+86-21-52996696 sales@lollanechem.com China 1912 55
Shanghaizehan biopharma technology co., Ltd. 0086-021-61350663 13052117465
0086-021-61350662 sales@zehanbiopharma.com China 823 55

View Lastest Price from AZD6738 manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-23 AZD6738
1352226-88-0
US $2.00 / kg 1kg 99% 100kg career henan chemical co

1352226-88-0(AZD6738)Related Search:


  • AZD6738
  • AZD-6738
  • 4-[4-[1-[[S(R)]-S-Methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine
  • AZD6738(AZD-6738)
  • -
  • (R)-imino(methyl)(1-(6-((R)-3-methylmorpholino)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)cyclopropyl)-l6-sulfanone
  • (3R)-3-Methyl-4-(6-((2R)-2-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin
  • EOS-61602
  • (R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine
  • 1H-Pyrrolo[2,3-b]pyridine, 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-
  • 1352226-88-0
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