ChemicalBook >> CAS DataBase List >>Prednisolone-21-acetate
Prednisolone-21-acetate
- CAS No.
- 52-21-1
- Chemical Name:
- Prednisolone-21-acetate
- Synonyms
- PREDNISOLONE ACETATE;Sterane;PREDNISOLONE 21-ACETATE;Econopred;Ak-Tate;Prenema;Deltilen;Durapred;Nisolone;Omnipred
- CBNumber:
- CB9274994
- Molecular Formula:
- C23H30O6
- Molecular Weight:
- 402.49
- MDL Number:
- MFCD00037710
- MOL File:
- 52-21-1.mol
Last updated:2024-03-22 14:56:24
| Melting point | 240-244 °C |
|---|---|
| alpha | D25 +116° (dioxane) |
| Boiling point | 579.8±50.0 °C(Predicted) |
| Density | 1.28±0.1 g/cm3(Predicted) |
| refractive index | 112 ° (C=1, Dioxane) |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. |
| pka | 12.41±0.70(Predicted) |
| color | White to Off-White |
| Water Solubility | 11.6mg/L(25 ºC) |
| Merck | 7721 |
| BRN | 3111798 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 52-21-1(CAS DataBase Reference) |
| FDA UNII | 8B2807733D |
| NIST Chemistry Reference | 1,4-Pregnadiene-3,20-dione, 11beta,17alpha,21-trihydroxy-, acetate(52-21-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD |
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 |
| Hazard Codes | N |
| Risk Statements | 25-34-11 |
| Safety Statements | 45-36/37/39-26-16 |
| WGK Germany | 3 |
| RTECS | TU4152500 |
| HS Code | 29372900 |
Prednisolone-21-acetate price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P8650 | Prednisolone 21-acetate ≥97% | 52-21-1 | 1g | $65.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | BP1140 | Prednisolone acetate British Pharmacopoeia (BP) Reference Standard | 52-21-1 | 100MG | $265 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1556008 | Prednisolone acetate United States Pharmacopeia (USP) Reference Standard | 52-21-1 | 200mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0000582 | Prednisolone acetate for peak identification European Pharmacopoeia (EP) Reference Standard | 52-21-1 | y0000582 | $220 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR1630 | Prednisolone acetate Pharmaceutical Secondary Standard; Certified Reference Material | 52-21-1 | 1g | $144 | 2024-03-01 | Buy |
Prednisolone-21-acetate Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Originator
Sterane, Phipharmex ,US ,1955
Uses
glucocorticoid
Uses
Synthetic corticosteroid; metabolically interconvertible with prednisone.
Definition
ChEBI: Prednisolone acetate is a corticosteroid hormone.
Manufacturing Process
To a solution of 0.85 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione (prednisolone) in 5 ml of pyridine are added 3 ml of acetic anhydride. The reaction mixture is allowed to stand at room temperature overnight and is then diluted with ice water. The resulting precipitate is filtered from the mixture and recrystallized from acetone-hexane. There is recovered 0.45 gram of 1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-acetate, MP 235°239°C. On recrystallization, the MP rose to 237°-239°C.
brand name
Econopred (Alcon); Meticortelone (Schering); Omnipred (Alcon); Sterane (Pfizer).
Therapeutic Function
Glucocorticoid
Biological Activity
Prednisolone Acetate (Omnipred) is a synthetic corticosteroid that is a particularly potent immunosuppressant.
Clinical Use
For rheumatoid arthritis, rheumatic fever, lupus erythematosus, scleroderma, dermatomyositis, acute lymphoblastic leukemia, etc.
Purification Methods
Recrystallise prednisolone acetate from EtOH, Me2CO, Me2CO/hexane, and it has UV with max at 243nm in EtOH. [Joly et al. Bull Soc Chim Fr 366 1958; Herzog et al. J Am Chem Soc 77 4781 1955, Beilstein 8 IV 3468.]
Prednisolone-21-acetate Preparation Products And Raw materials
Global( 461)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| APOLLO HEALTHCARE RESOURCES | +6596580999 | sales@apollo-healthcare.com.sg | Singapore | 400 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 | Jany1001@kangcang.com.cn | China | 338 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 | bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
View Lastest Price from Prednisolone-21-acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-19 | Prednisolone Acetate
52-21-1
|
US $20.00-10.00 / kg | 1kg | 98% | 20 | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-19 | Prednisolone Acetate
52-21-1
|
US $9.00-60.00 / g | 10g | min99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-03-16 | Prednisolone-21-acetate
52-21-1
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD |
-
- Prednisolone Acetate
52-21-1
- US $20.00-10.00 / kg
- 98%
- Hebei Kangcang new material Technology Co., LTD
-
- Prednisolone Acetate
52-21-1
- US $9.00-60.00 / g
- min99%
- Hebei Kangcang new material Technology Co., LTD
-
- Prednisolone-21-acetate
52-21-1
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
52-21-1(Prednisolone-21-acetate )Related Search:
PRICORTIN
1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL 3,20-DIONE 21-ACETATE
1,4-PREGNADIENE-3,20-DIONE-11BETA,17ALPHA,21-TRIOL 21-ACETATE
1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE 21-ACETATE
1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
1-DEHYDROCORTISOL 21-ACETATE
21-ACETOXY-1,4-PREGNADIENE-11BETA,17ALPHA-DIOL-3,20-DIONE
METACORTANDROLONE ACETATE
(11beta)-21-(Acetyloxy)-11,17-dihydroxypregna-1,4-diene-3,20-dione
11,17-Dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
11beta,17,21-Trihydroxypregna-1,4-diene-3,20-dione 21-acetate
21-(acetyloxy)-11,17-dihydroxy-4-diene-(11-beta)-pregna-20-dione
21-(acetyloxy)-11,17-dihydroxy-4-diene-(11beta)-pregna-20-dione
4-diene-3,20-dione,11-beta,17,21-trihydroxy-pregna-21-acetate
Ak-Tate
component of Blephamide liquifilm,
component of Blephamide sop,
component of Cetapred ointment,
component of Composone
component of Isopto Cetapred
component of Metimyd
component of Mydapred,
component of Neo-delta-Cortef
component of Neo-delta-cortef,
component of Poly-pred,
component of Pred-g liquifilm,
component of Pred-g sop,
component of Vasocidin ointment
Cormalone
Cortipred
Delcort-E
Deltilen
Durapred
Hostacortin H
Meticortelone acetate
meticorteloneacetate
Meticotelone acetate
Nisolone
Pred Forte
Pred Forte TM
Pred Mild
Predalone 50
Prediacortine
Predicort
Prednelan-N
Prednidoren
Predonine injection
predonineinjection
Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-, 21-acetate
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-11,17-dihydroxy-, (11beta)-
Prenema
Sterane IM and IA
Supercortyl
Prednisolone acetate micron
PREDNISOLONE 21-ACETATE VETRANAL, 250 MG
DELTACORTENOLO
INFLANEFRAN
HYDROCORTIDELT