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CID-49830258

CAS No.
1346527-98-7
Chemical Name:
CID-49830258
Synonyms
ML240;CS-2775;ML240, >98%;CID-49830258;ML240 >=98% (HPLC);Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97;2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine;2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine;4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-
CBNumber:
CB92751093
Molecular Formula:
C23H20N6O
Molecular Weight:
396.44
MDL Number:
MFCD28137687
MOL File:
1346527-98-7.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

CID-49830258 Properties

Boiling point 696.6±65.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL, clear (warmed)
form powder
pka 4.53±0.10(Predicted)
color white to yellow to light brown

SAFETY

Risk and Safety Statements

WGK Germany  3

CID-49830258 price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1071 ML240 ≥98% (HPLC) 1346527-98-7 5mg $81 2024-03-01 Buy
Sigma-Aldrich SML1071 ML240 ≥98% (HPLC) 1346527-98-7 25mg $535 2024-03-01 Buy
Cayman Chemical 17373 ML-240 ≥95% 1346527-98-7 1mg $49 2024-03-01 Buy
Cayman Chemical 17373 ML-240 ≥95% 1346527-98-7 5mg $109 2024-03-01 Buy
Cayman Chemical 17373 ML-240 ≥95% 1346527-98-7 10mg $168 2024-03-01 Buy
Product number Packaging Price Buy
SML1071 5mg $81 Buy
SML1071 25mg $535 Buy
17373 1mg $49 Buy
17373 5mg $109 Buy
17373 10mg $168 Buy

CID-49830258 Chemical Properties,Uses,Production

Uses

ML 240 is a p97 inhibitor in cancer and neurodegenerative diseases.

Uses

ML240 has been used as an inhibitor of D2 ATPase activity of valosin-containing protein.

Definition

ChEBI: ML240 is a member of the class of quinazolines that is quinazoline which is substituted at positions 2, 5 and 8 by 2-amino-1H-benzimidazol-1-yl, benzylnitrilo and methoxy groups, respectively. It is a ATP-competetive inhibitor of AAA ATPase p97, also known as valosin-containing protein (VCP). It has a role as an antineoplastic agent. It is a member of quinazolines, a member of benzimidazoles, a secondary amino compound, an aromatic amine, an aromatic ether and a primary amino compound.

Biochem/physiol Actions

ML240 is a selective, ATP-competetive inhibitor of AAA ATPase p97, also called valosine containing protein (VCP). The IC50 for p97 inhibition is 110 nM. ML240 rapidly induces activity of Caspases 3 and 7, leading to apoptosis. ML240 has potent antiproliferative activity towards NCI-60 cancer cell lines.

storage

Store at +4°C

CID-49830258 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 79)Suppliers
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ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32480 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem
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LEAP CHEM CO., LTD.
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TargetMol Chemicals Inc.
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ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
Mashilabs (Shanghai) Co.,Ltd. 021-00000000 19916721580 info@mashilabs.com China 4115 58
2-(2-Amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine CID-49830258 ML240 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine CS-2775 ML240, >98% 4-Quinazolinamine, 2-(2-amino-1H-benzimidazol-1-yl)-8-methoxy-N-(phenylmethyl)- ML240 >=98% (HPLC) Cdc48,inhibit,VCP,Inhibitor,ML240,ML 240,ML-240,p97 1346527-98-7 API