4-PHENOXYPHENYLBORONIC ACID
- CAS No.
- 51067-38-0
- Chemical Name:
- 4-PHENOXYPHENYLBORONIC ACID
- Synonyms
- EOS-61617;AKOS BRN-0132;RARECHEM AH PB 0260;TIMTEC-BB SBB003409;Ibrutinib Impurity 36;4-PHENOXYPHENYLBORONI;4-Boronodiphenyl ether;4-PHENOXYPHENYLBORONIC;4-phenoxy-phenylboric acid;4-PHENOXYPHENYLBORONIC ACID
- CBNumber:
- CB9278200
- Molecular Formula:
- C12H11BO3
- Molecular Weight:
- 214.02
- MDL Number:
- MFCD00093312
- MOL File:
- 51067-38-0.mol
- MSDS File:
- SDS
Melting point | 141-145 °C(lit.) |
---|---|
Boiling point | 377.0±44.0 °C(Predicted) |
Density | 1.23±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
pka | 8.76±0.10(Predicted) |
form | Crystalline Powder |
color | White to beige |
InChI | InChI=1S/C12H11BO3/c14-13(15)10-6-8-12(9-7-10)16-11-4-2-1-3-5-11/h1-9,14-15H |
InChIKey | KFXUHRXGLWUOJT-UHFFFAOYSA-N |
SMILES | B(C1=CC=C(OC2=CC=CC=C2)C=C1)(O)O |
CAS DataBase Reference | 51067-38-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 37/39-26 | |||||||||
WGK Germany | 3 | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29319090 | |||||||||
NFPA 704 |
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4-PHENOXYPHENYLBORONIC ACID price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 480142 | 4-Phenoxyphenylboronic acid ≥95.0% | 51067-38-0 | 5g | $49.14 | 2024-03-01 | Buy |
Sigma-Aldrich | 480142 | 4-Phenoxyphenylboronic acid ≥95.0% | 51067-38-0 | 25g | $363 | 2023-06-20 | Buy |
TCI Chemical | P1974 | 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) | 51067-38-0 | 5g | $57 | 2024-03-01 | Buy |
TCI Chemical | P1974 | 4-Phenoxyphenylboronic Acid (contains varying amounts of Anhydride) | 51067-38-0 | 25g | $169 | 2024-03-01 | Buy |
Alfa Aesar | H52950 | 4-Phenoxybenzeneboronic acid, 98% | 51067-38-0 | 1g | $31.65 | 2024-03-01 | Buy |
4-PHENOXYPHENYLBORONIC ACID Chemical Properties,Uses,Production
Chemical Properties
white to off-white powder and chunk
Uses
4-Phenoxyphenylboronic acid can be used as a reactant:
- In the Suzuki-Miyaura coupling reaction to synthesize aryl derivatives via C-C bond formation by reacting with different aryl halides over a palladium catalyst.
- To prepare 1-phenoxy-4-(trifluoromethyl)benzene via oxidative trifluoromethylation using Chan-Lam-type reaction conditions.
- To synthesize evobrutinib, a potent Bruton′s tyrosine kinase (BTK) inhibitor.
Uses
4-Phenoxybenzeneboronic Acid is an intermediate used to prepare biphenyl derivatives of nitotrifluoromethoxybenzyloxydihydroimidazooxazines with antitubercular activity. It is also used in the synthesis of pyrrolo pyrimidines as potent inhibitors of Lck kinase.
Uses
suzuki reaction
Synthesis
4-Bromodiphenyl ether (100 g, 0.402 mol)Was dissolved in anhydrous THF (800 mL)Under nitrogen protection,Cooled to -78 ° C,N-butyllithium (n-BuLi) (177 mL, 0.442 mol)The temperature is kept below -65 ° C,After stirring for 1 h,Continue to maintain the temperature -60 ,Triisopropyl borate (90 g, 0.482 mol) was added dropwise,Slowly rose to 0 ° C, stir for 3 h.Water (300 mL) was added under ice bath overnight. The reaction solution was concentrated to remove the organic phase,With 12N concentrated hydrochloric acid pH adjusted to 1 ~ 2,Precipitation of solids,Filtration and drying gave 4-phenoxyphenylboronic acid (77 g, yield 90%).
4-PHENOXYPHENYLBORONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
China Synchem Technology Co.,Ltd. | +86-0552-4929304 +86-18055277008 | wangxuhui1985@126.com | China | 57 | 55 |
Hebei Maison Chemical Co.,Ltd. | +8615511852758 | sales@maisonchem.com.cn | China | 484 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5866 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18629 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9354 | 55 |
View Lastest Price from 4-PHENOXYPHENYLBORONIC ACID manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-19 | 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-09-14 | 4-Phenoxyphenylboronic acid
51067-38-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | ||
2024-08-15 | 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
|
US $40.00-40.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
- 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
- US $9.00 / KG
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
- 4-Phenoxyphenylboronic acid
51067-38-0
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
- 4-PHENOXYPHENYLBORONIC ACID
51067-38-0
- US $40.00-40.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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