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3-Acetylpyridine

Identification Description Regulatory Status Usage Natural occurrence
3-Acetylpyridine
3-Acetylpyridine
CAS No.
350-03-8
Chemical Name:
3-Acetylpyridine
Synonyms
NSC 761;FEMA 3424;Imatinib-int A;3-ACETOPYRIDINE;3-ActylPyridine;3-acetyl-pyridin;3-Acetylpiridine;3-ACETYLPYRIDINE;FEMA NUMBER 3424;3-Acetalpyridine
CBNumber:
CB9286704
Molecular Formula:
C7H7NO
Formula Weight:
121.14
MOL File:
350-03-8.mol

3-Acetylpyridine Properties

Melting point:
11-13 °C(lit.)
Boiling point:
220 °C(lit.)
Density 
1.102 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.534(lit.)
FEMA 
3424 | 3-ACETYLPYRIDINE
Flash point:
302 °F
storage temp. 
Refrigerator
form 
Liquid
color 
Clear colorless to yellow
PH
6.5-7.5 (H2O, 20℃)
Water Solubility 
SOLUBLE IN HOT WATER
Merck 
14,6116
BRN 
107751
InChIKey
WEGYGNROSJDEIW-UHFFFAOYSA-N
CAS DataBase Reference
350-03-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(3-pyridinyl)-(350-03-8)
EPA Substance Registry System
Ethanone, 1-(3-pyridinyl)-(350-03-8)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T,Xi,Xn
Risk Statements  25-36/38-36/37/38-20/21/22
Safety Statements  45-37/39-28A-26-36
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  OB5425000
8-10
Hazard Note  Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

3-Acetylpyridine price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 04642 3-Acetylpyridine analytical standard 350-03-8 1ml-f $20.8 2017-11-08 Buy
Sigma-Aldrich 8.00155 Methyl 3-pyridyl ketone for synthesis 350-03-8 1EA $70.5 2017-11-08 Buy
TCI Chemical A0112 3-Acetylpyridine >98.0%(GC) 350-03-8 25g $40 2017-11-08 Buy
TCI Chemical A0112 3-Acetylpyridine >98.0%(GC) 350-03-8 250g $208 2017-11-08 Buy
Alfa Aesar A14246 3-Acetylpyridine, 98% 350-03-8 25g $36.4 2017-11-08 Buy

3-Acetylpyridine Chemical Properties,Uses,Production

Identification

CAS.No.:  350-03-8  FL.No.:  14.039 FEMA.No.:  3424 NAS.No.:  3424
CoE.No.:  2316 EINECS.No.:  206-496-7  JECFA.No.:  1316    

Description

A colorless liquid with sweet, nutty, popcorn-like aroma.

Regulatory Status

CoE: Used provisionally. Bev.: 2 ppm; Food: 3 ppm
FDA: n/a
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2004).

Usage

Reported uses (ppm): (FEMA, 1994)
Food Category  Usual  Max. 
Baked goods  2 3
Frozen dairy  1 2
Gelatins,puddings  1 2
Nonalcoholic beverages  1 2
Soft candy  2 3

Natural occurrence

Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.

Chemical Properties

clear colorless to yellow liquid

Purification Methods

It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]

3-Acetylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products


3-Acetylpyridine Suppliers

Global( 368)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Anqing Chico Pharmaceutical Co., Ltd.
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View Lastest Price from 3-Acetylpyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 3-Acetylpyridine
350-03-8
US $100.00 / KG 1KG 99% Customized

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