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3-Acetylpyridine

Identification Description Regulatory Status Usage Natural occurrence
3-Acetylpyridine
3-Acetylpyridine structure
CAS No.
350-03-8
Chemical Name:
3-Acetylpyridine
Synonyms
NSC 761;FEMA 3424;Imatinib-int A;3-ActylPyridine;3-ACETOPYRIDINE;3-acetyl-pyridin;3-Acetylpiridine;3-Acetalpyridine;3-acetyl pyrdine;3-ACETYLPYRIDINE
CBNumber:
CB9286704
Molecular Formula:
C7H7NO
Formula Weight:
121.14
MOL File:
350-03-8.mol

3-Acetylpyridine Properties

Melting point:
11-13 °C(lit.)
Boiling point:
220 °C(lit.)
Density 
1.102 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.534(lit.)
FEMA 
3424 | 3-ACETYLPYRIDINE
Flash point:
302 °F
storage temp. 
Refrigerator
form 
Liquid
pka
pK1: 3.256(+1) (25°C)
Specific Gravity
1.102
color 
Clear colorless to yellow
PH
6.5-7.5 (H2O, 20℃)
Water Solubility 
SOLUBLE IN HOT WATER
Merck 
14,6116
JECFA Number
1316
BRN 
107751
InChIKey
WEGYGNROSJDEIW-UHFFFAOYSA-N
CAS DataBase Reference
350-03-8(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(3-pyridinyl)-(350-03-8)
EPA Substance Registry System
Ethanone, 1-(3-pyridinyl)-(350-03-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07,GHS06
Signal word  Danger
Hazard statements  H300-H315-H319-H301
Precautionary statements  P264-P270-P280-P301+P310+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P405-P501-P301+P310-P280h-P305+P351+P338-P309-P310
Hazard Codes  T,Xi,Xn
Risk Statements  25-36/38-36/37/38-20/21/22
Safety Statements  45-37/39-28A-26-36
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  OB5425000
8-10
Hazard Note  Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999

3-Acetylpyridine price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A21207 3-Acetylpyridine 98% 350-03-8 10g $22.2 2018-11-13 Buy
Sigma-Aldrich A21207 3-Acetylpyridine 98% 350-03-8 100g $110 2018-11-13 Buy
TCI Chemical A0112 3-Acetylpyridine >98.0%(GC) 350-03-8 25g $42 2018-11-22 Buy
TCI Chemical A0112 3-Acetylpyridine >98.0%(GC) 350-03-8 250g $217 2018-11-22 Buy
Alfa Aesar A14246 3-Acetylpyridine, 98% 350-03-8 100g $106 2018-11-13 Buy

3-Acetylpyridine Chemical Properties,Uses,Production

Identification

CAS.No.: 
350-03-8 
FL.No.: 
14.039
FEMA.No.: 
3424
NAS.No.: 
3424
CoE.No.: 
2316
EINECS.No.: 
206-496-7 
JECFA.No.: 
1316
 
 

Description

A colorless liquid with sweet, nutty, popcorn-like aroma.

Regulatory Status

CoE: Used provisionally. Bev.: 2 ppm; Food: 3 ppm
FDA: n/a
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2004).

Usage

Reported uses (ppm): (FEMA, 1994)
Food Category 
Usual 
Max. 
Baked goods 
2
3
Frozen dairy 
1
2
Gelatins,puddings 
1
2
Nonalcoholic beverages 
1
2
Soft candy 
2
3

Natural occurrence

Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.

Chemical Properties

clear colorless to yellow liquid

Chemical Properties

A colorless liquid with sweet, nutty, popcorn-like aroma

Occurrence

Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.

Preparation

Dry distillation of calcium nicotinate with calcium acetate.

Definition

It is a nicotinic acidantagonist.

Safety Profile

Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONES

Purification Methods

It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]

3-Acetylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products


3-Acetylpyridine Suppliers

Global( 401)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Anqing Chico Pharmaceutical Co., Ltd.
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View Lastest Price from 3-Acetylpyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-01 3-Acetylpyridine
350-03-8
US $100.00 / KG 1KG 99% Customized career henan chemical co

3-Acetylpyridine Spectrum


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