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Bulleyaconitine A

Bulleyaconitine A structure

CAS No.: 107668-79-1

Chemical Name:: Bulleyaconitine A

Synonyms: Bulleyaconitine;BULLEYACONITINE A;Bulleyaconi cine A;BULLEYACONITINE A(P);BULLEYACONITINE A(RG);Aconitane,Methanone deriv;Bulleyaconitine A USP/EP/BP;crassicauline A(bulleyaconitine;(-)-Syringaresinol 4-O-β-D-glucopyranosi;Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)-

CBNumber:: CB9291737

Molecular Formula:: C35H49NO9

Molecular Weight:: 627.76

MDL Number:: MFCD01714791

MOL File:: 107668-79-1.mol

MSDS File:: SDS

Last updated:2023-06-08 13:53:37

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Bulleyaconitine A Properties

Boiling point	690.9±55.0 °C(Predicted)
Density	1.28±0.1 g/cm3(Predicted)
storage temp.	Store at 2-8°C
solubility	DMSO: 125 mg/mL (199.12 mM)
pka	13.12±0.70(Predicted)
FDA UNII	7VFN6Z3BRE

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H330-H300
Precautionary statements	P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501

Bulleyaconitine A price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B689710	BulleyaconitineA	107668-79-1	10mg	$140	2021-12-16	Buy
Usbiological	300033	Bulleyaconitine A	107668-79-1	20mg	$280	2021-12-16	Buy
ChemScene	CS-3592	BulleyaconitineA 99.09%	107668-79-1	100mg	$390	2021-12-16	Buy
Biorbyt Ltd	orb593800	Bulleyaconitine A	107668-79-1	100mg	$408	2021-12-16	Buy
Biorbyt Ltd	orb104628	Bulleyaconitine A >98%,Standard References Grade	107668-79-1	20mg	$569.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
B689710	10mg	$140	Buy
300033	20mg	$280	Buy
CS-3592	100mg	$390	Buy
orb593800	100mg	$408	Buy
orb104628	20mg	$569.5	Buy

Bulleyaconitine A Chemical Properties,Uses,Production

Description

Bulleyaconitine A is an aconitine-type two terpene alkaloid, and its molecular formula is C35H49NO10.?As early as 1980, bulleyaconitine was separated and extracted from a traditional analgesic and anti-inflammatory herb in the west of Yunnan called dianxi dula (or dianxi wutou) (Aconitum bulleyanum Diels), by the Kunming Institute of Botany, Chinese Academy of Sciences . At present, bulleyaconitine A can be separated from Aconitum plants, for example, dianxi wutou (Aconitum bulleyanum Diels), cujing wutou (Aconitum crassicaule W.T.?Wang), changhui wutou (Aconitum georgei Comber), and zhiyuan wutou (Aconitum transsectum Diels).

Physical properties

Appearance: white powder. Solubility: soluble in methanol, ethanol, chloroform, and ether; insoluble in water; and easily dissolved in dilute hydrochloric acid or dilute sulfuric acid . Melting point: 160–165?°C

History

In 1983, it was confirmed that bulleyaconitine A shows obvious analgesic and antiinflammatory effects by preclinical pharmacological tests . Clinical trials were carried out in 29 hospitals in 9 provinces in 1984. Bulleyaconitine A passed technical appraisals in May 1985 and was first formally put into production by Yunnan Honghe Pingbian pharmaceutical company, where it obtained the trade name “Bulleyaconitine A.” Bulleyaconitine A has been listed into the Pharmacopoeia of the People’s Republic of China (2015). In recent years, bulleyaconitine A has shown a great market growth and competitive power, owing to its exact curative effect and rapid clinical promotion in chronic disease and rheumatic immune disease.

Uses

Bulleyaconitine A is an agent that expresses long-lasting local anaesthetic properties used in the treatment of chronic pain and arthritis. Commonly used in China as a traditional medicine.

Pharmacology

1. Anti-inflammatory and analgesic effect. Bulleyaconitine A plays a significant anti-inflammatory effect by inhibiting the release of prostaglandins. The analgesic effect may be related to the rivalry of 5-HT and the inhibition of inflammatory chemokines in the brain, because inhibition of PGE2 release may lead to disinhibition of β-endorphin . Further studies showed that bulleyaconitine A achieved the analgesic effect by effectively reducing sodium ion current, the electrophysiological basis on which pain conduction is dependent . Zhanguo Niu et?al. found that bulleyaconitine A could be used to treat mild and moderate burn pain, with less adverse reactions and no addiction . Thus, bulleyaconitine A may be suitable for long-term use as a choice of analgesic therapy for burn pain. Recently, through clinical observation on the effect of bulleyaconitine A treatment in acute gouty arthritis, some scholars discovered that bulleyaconitine A brought about good effect and could effectively improve the clinical symptoms of patients by taking 0.4?mg bulleyaconitine A orally three times in daily .
2. Immune regulation. Bulleyaconitine A has obvious inhibitory effects to immune cells involved in joint inflammation, which may have a close relationship to its clinical anti-inflammatory effect. Ye Lu et?al. studied the influence of bulleyaconitine A on partial immune functions of BALB/c mice and found that 0.32?mg/kg bulleyaconitine A inhibits some immune functions of BALB/c mice . Moreover, it was reported that bulleyaconitine A significantly inhibited the phagocytic function and the ability to secrete nitric oxide (NO) of macrophages .
3. Other pharmacological effects. An injection of 0.1 mg/kg bulleyaconitin A in fasting rat can inhibit the formation of corneal neovascularization induced by alkali burn . Bulleyaconitine A also has local anesthesia and antipyretic effect. Besides, bulleyaconitine A can be used for the treatment of lumbar muscle strain, scapulohumeral periarthritis, and sprain of limbs.

Clinical Use

1. Rheumatic immune disease. Since listing, bulleyaconitine A has been applied in clinical treatment for rheumatoid arthritis and osteoarthritis, receiving good curative effects.
2. Chronic pain. Bulleyaconitine A does not belong to NSAID, and it exerts its effects by regulating the sodium ion channel. So there is little psychological dependence and organ toxicity, avoiding gastrointestinal/cardiovascular/renal adverse reactions and drug dependence or other potential dangers caused by NSAID and opioid analgesics.

Bulleyaconitine A Preparation Products And Raw materials

Raw materials

Preparation Products

Bulleyaconitine A Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu Biopurify Phytochemicals Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Xi'an Kono chem co., Ltd.,	58
Shaanxi Pioneer Biotech Co., Ltd .	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58

View Lastest Price from Bulleyaconitine A manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-18	Bulleya conitine A 107668-79-1	US $120.00 / KG	1250KG	99%	330T	Xiamen Wonderful Bio Technology Co., Ltd.
2023-02-24	Bulleyaconitine A 107668-79-1	US $0.00 / mg	5mg	≥98%(HPLC)	10 g	Shanghai Standard Technology Co., Ltd.
2023-02-13	Bulleyaconitine A 107668-79-1	US $110.00 / kg	1kg	99%	80MT	Hebei baicao biology science and technology co., ltd

Bulleya conitine A
107668-79-1
US $120.00 / KG
99%
Xiamen Wonderful Bio Technology Co., Ltd.

Bulleyaconitine A
107668-79-1
US $0.00 / mg
≥98%(HPLC)
Shanghai Standard Technology Co., Ltd.

Bulleyaconitine A
107668-79-1
US $110.00 / kg
99%
Hebei baicao biology science and technology co., ltd

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16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-y-6 methanone,((1-alpha,6-alpha,14-alpha,16-beta)-8-(acetyloxy)-20-ethyl-13-hydrox BULLEYACONITINE A METHANONE, [(1,6,14,16)-8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)- BULLEYACONITINE A: METHANONE, [(1,6,14,16) -8-(ACETYLOXY)-20-ETHYL-13-HYDROXY-1,6,16-TRIMETHOXY-4-(METHOXYMETHYL)ACONITAN-14-YL](4-METHOXYPHENYL)-, BULLEYACONITINE A(P) 20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- Methanone, [(1α,6α,14α,16β) -8-(acetyloxy)- Bulleyaconi cine A BULLEYACONITINE A(RG) Aconitane,Methanone deriv Methanone, [(1a,6a,14a,16b)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl](4-methoxyphenyl)- Bulleyaconitine ((1-α,6-α,14-α,16-β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-yl)(4-methoxyphenyl)-methanone Bulleyaconitine A, 98%, from Aconitum kusnezoffii Rchb. crassicauline A(bulleyaconitine Methanone, [(1α,6α,14α,16β)-8-(acetyloxy)-20-ethyl-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl) aconitan-14-yl](4-methoxyphenyl)- Bulleyaconitine A USP/EP/BP (-)-Syringaresinol 4-O-β-D-glucopyranosi 107668-79-1 79572-91-9 C35H49NO9 standardized herbal extract Inhibitors Natural Plant Extract chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM).