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5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE structure

CAS No.: 64273-28-5

Chemical Name:: 5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE

Synonyms: 5-methyl-4-phenylthiadiazole;5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE;1,2,3-Thiadiazole, 5-methyl-4-phenyl-

CBNumber:: CB9294824

Molecular Formula:: C9H8N2S

Molecular Weight:: 176.24

MDL Number:: MFCD00100201

MOL File:: 64273-28-5.mol

Last updated:2023-05-21 10:59:17

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5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Properties

storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥10.38 mg/mL in EtOH; ≥7.85 mg/mL in DMSO
form	solid
color	Red-brown

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P271-P261-P280

Hazard Codes

Risk Statements

Hazard Note

Harmful

HS Code

2934999090

NFPA 704

	1
2		0

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	T344123	4-Phenyl-5-methyl-1,2,3-Thiadiazole	64273-28-5	500mg	$70	2021-12-16	Buy
Apolloscientific	OR26197	5-Methyl-4-phenyl-1,2,3-thiadiazole 95%	64273-28-5	1g	$86	2021-12-16	Buy
SynQuest Laboratories	7H70-1-V0	5-Methyl-4-phenyl-1,2,3-thiadiazole 95%	64273-28-5	1g	$95	2021-12-16	Buy
Matrix Scientific	084918	5-Methyl-4-phenyl-1,2,3-thiadiazole 97%	64273-28-5	1g	$102	2021-12-16	Buy
AK Scientific	V7087	5-Methyl-4-phenyl-1,2,3-thiadiazole	64273-28-5	1g	$104	2021-12-16	Buy

Product number	Packaging	Price	Buy
T344123	500mg	$70	Buy
OR26197	1g	$86	Buy
7H70-1-V0	1g	$95	Buy
084918	1g	$102	Buy
V7087	1g	$104	Buy

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Chemical Properties,Uses,Production

Uses

4-phenyl-5-methyl-1,2,3-Thiadiazole is a selective, mechanism-based inhibitor of CYP2B4 and CYP2E1.

Biological Activity

4-phenyl-5-methyl-1,2,3-thiadiazole is a cyp2b4 and cyp2e1 inhibitor.cytochrome p450 (cyp450) enzymes, a superfamily of oxidative catalysts, are important in the biosynthesis and metabolism of a wide range of endogenous molecules and the metabolism of xenobiotics. cyp2b4 can metabolize substituted amines, while cyp2e1 metabolizes various alcohols and halogenated alkenes.

in vitro

4-phenyl-5-methyl-1,2,3-thiadiazole (pmt) was found to be slightly more inhibitory to p450s 2e1 and 1a2 than its close analog, 4,5-diphenyl-1,2,3-thiadiazole (dpt). by contrast, 4-phenyl-5-hydrogen-1,2,3-thiadiazole (pt), a weaker inhibitor than dpt and pmt with p450s 2e1 and 2b4, was comparable to pmt and more effective than dpt with p450 1a2. moreover, pmt, dpt, as well as pt showed no inactivation of either p450 2e1 or 2b4, though they were fairly effective inhibitors, and the thiadiazole ring could be oxidized by the p450 system. furthremore, the lack of inactivation of the p450 isoforms by pmt, dpt, and pt suggested that a transient reactive intermediate was not formed on oxidation of the thiadiazole ring. in additioin, the 1,2,3-thiadiazole ring could be oxidized by the p450 system [1].

References

[1] babu, b. r. and vaz, a.d.n. 1,2,3-thiadiazole: a novel heterocyclic heme ligand for the design of cytochrome p450 inhibitors. biochemistry 36, 7209-7216 (1997).

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE Suppliers

Global( 23)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30132	84
Beijing FYF Chemicals Co., Ltd	15318973357	1460285141@qq.com	China	2947	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Shanghai Haohong Scientific Co., Ltd.	400-400-8210725	malulu@leyan.com	China	40041	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5019	58
ApexBio Technology	--	sales@apexbt.com	United States	6254	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Beijing FYF Chemicals Co., Ltd	58
MedBioPharmaceutical Technology Inc	58
Energy Chemical	58
Shanghai Haohong Scientific Co., Ltd.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58
ApexBio Technology	58

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5-METHYL-4-PHENYL-1,2,3-THIADIAZOLE 5-methyl-4-phenylthiadiazole 1,2,3-Thiadiazole, 5-methyl-4-phenyl- 64273-28-5 C9H8N2S