Poly(1-vinylpyrrolidone-co-vinyl acetate)
- CAS No.
- 25086-89-9
- Chemical Name:
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
- Synonyms
- VP/VA COPOLYMER;pvp-va;kollidonva64;VINYLPYRROLIDONE-VINYL ACETATE COPOLYMER;e335;N-VINYLPYRROLIDONE/VINYL ACETATE COPOLYMER;e535;s630;i535;i635
- CBNumber:
- CB9295023
- Molecular Formula:
- C10H15NO3
- Molecular Weight:
- 197.23
- MDL Number:
- MFCD00134018
- MOL File:
- 25086-89-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.27 g/mL at 25 °C(lit.) |
|---|---|
| Tg | 108 |
| refractive index | 1.4300 to 1.4380 |
| Flash point | 72 °F |
| solubility | Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane. |
| form | powder |
| color | White |
| Viscosity | 800.0 to 3000.0 mPa-s |
| Stability | Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents. |
| Major Application | pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions |
BINDING FILM FORMING HAIR FIXING |
| InChI | InChI=1S/C6H9NO.C4H6O2/c1-2-7-5-3-4-6(7)8;1-3-6-4(2)5/h2H,1,3-5H2;3H,1H2,2H3 |
| InChIKey | FYUWIEKAVLOHSE-UHFFFAOYSA-N |
| SMILES | C(N1CCCC1=O)=C.O(C=C)C(=O)C |
| LogP | 0.370 (est) |
| Indirect Additives used in Food Contact Substances | POLY(VINYL ACETATE-CO-VINYLPYRROLIDONE) |
| FDA 21 CFR | 175.105; 176.170; 176.180 |
| FDA UNII | D9C330MD8B |
| EPA Substance Registry System | Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 10-36/37/38-67-36-11-22 | |||||||||
| Safety Statements | 22-24/25-36/37/39-26-16 | |||||||||
| RIDADR | UN 1987 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | AH3539000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29349990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Toxicity | LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83 | |||||||||
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Poly(1-vinylpyrrolidone-co-vinyl acetate) price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0002138 | Copovidone CRS, European Pharmacopoeia (EP) Reference Standard | 25086-89-9 | 60 mg | $169 | 2026-04-30 | Buy |
| Sigma-Aldrich | 190837 | Poly(1-vinylpyrrolidone-co-vinyl acetate) solution average Mw ~13,000 (GPC vs. poly(ethylene oxide)), 50 wt. % in isopropanol | 25086-89-9 | 500g | $232 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1148500 | Poly(1-vinylpyrrolidone-co-vinyl acetate) solution United States Pharmacopeia (USP) Reference Standard | 25086-89-9 | 100mg | $511 | 2026-04-30 | Buy |
| TCI Chemical | P0382 | Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol) | 25086-89-9 | 25g | $19 | 2026-04-30 | Buy |
| TCI Chemical | P0382 | Poly(1-vinylpyrrolidone-co-Vinyl Acetate) (Copolymer, 7:3) (50% in Ethanol) | 25086-89-9 | 500g | $70 | 2026-04-30 | Buy |
Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties, Uses, Production
Chemical Properties
Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.
Chemical Properties
white powder
Uses
Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches.
Uses
Poly(1-vinylpyrrolidone-co-vinyl acetate)
Production Methods
Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water.
General Description
~1:2.4 mole ratio of VP:VA
Pharmaceutical Applications
Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier.
Safety Profile
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
Safety
Copovidone is used widely in pharmaceutical formulations and is
generally regarded as nontoxic. However, it is moderately toxic by
ingestion, producing gastric disturbances. It has no irritating or
sensitizing effects on the skin. A study was conducted to look at the
carcinogenicity and chronic toxicity of copovidone (Kollidon VA
64) in Wistar rats and Beagle dogs. The results of these studies
demonstrated the absence of any significant toxicological findings
of high dietary levels of copodivone in rats and dogs, resulting in noobserved-
adverse-effect levels of 2800 mg/kg body-weight/day in
rats and 2500 mg/kg body-weight/day in dogs, the highest doses
tested.
LD50 (rat, oral): >0.63 g/kg
Solubility in organics
Acetone, chloroform, methanol, THF, water
Solubility in organics
THF (above 68C)
Solubility in organics
THF, water
storage
Copovidone is stable and should be stored in a well-closed container in a cool, dry place.
Incompatibilities
Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.
Regulatory Status
Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).
Poly(1-vinylpyrrolidone-co-vinyl acetate) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Word Chemical Technology Co., Ltd. | 15972179313 15972179313 | 2562513574@qq.com | China | 1295 | 58 |
| Shanghai Chengyu Biotechnology Co., Ltd. | 021-51525055 | 309639130@qq.com | China | 42 | 58 |
| Shanghai Linchen Pharmaceutical Technology co.,LTD | 021-31606595 13761181955 | info@linchenpharm.com | China | 195 | 58 |
| Zhongshan Xingrui Chemical Co. , Ltd. | 13380886747 | 1322625950@qq.com | China | 1408 | 58 |
| Wuhan Wiseman Bioengineering Co.,Ltd | 13419526507 13419526507 | 13419526507@163.com | China | 2631 | 58 |
| Hubei Huachuangyuan New Materials Co., Ltd | 027-19807233353 19807233353 | 2196036335@qq.com | China | 243 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44852 | 61 |
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View Latest Price from Poly(1-vinylpyrrolidone-co-vinyl acetate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-06 | Poly(1-vinylpyrrolidone-co-vinyl acetate)
25086-89-9
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-30 | Poly(1-vinylpyrrolidone-co-vinyl acetate)
25086-89-9
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-20 | Poly(1-vinylpyrrolidone-co-vinyl acetate)
25086-89-9
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
25086-89-9
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
25086-89-9
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Poly(1-vinylpyrrolidone-co-vinyl acetate)
25086-89-9
- $1.10
- 99.00%
- Dideu Industries Group Limited
